This article is a correction to:
The MYC Paralog-PARP1 Axis as a Potential Therapeutic Target in MYC Paralog-Activated Small Cell Lung Cancer
Xing Bian1,2,3,4
Xiaolin Wang1,2,3,4
Qiuyan Zhang5Liying Ma1,2,3,4Guozhen Cao1,2,3,4Ao Xu6,7Jinhua Han8
Jun Huang8
Wenchu Lin1,3,4*- 1High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, China
- 2University of Science and Technology of China, Hefei, China
- 3Key Laboratory of High Magnetic Field and Ion Beam Physical Biology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China
- 4High Magnetic Field Laboratory of Anhui Province, Hefei, China
- 5The CAS Key Laboratory of Innate Immunity and Chronic Disease, Innovation Center for Cell Signaling Network, School of Life Sciences, University of Science and Technology of China, Hefei, China
- 6The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China
- 7Department of Pathology, Anhui Provincial Hospital, Hefei, China
- 8MOE Key Laboratory for Biosystems Homeostasis & Protection and Innovation Center for Cell Signaling Network, Life Sciences Institute, Zhejiang University, Hangzhou, China
A corrigendum on
The MYC paralog-PARP1 axis as a potential therapeutic target in MYC paralog-activated small cell lung cancer
by Bian X, Wang X, Zhang Q, Ma L, Cao G, Xu A, Han J, Huang J and Lin W (2020) Front. Oncol. 10:565820. doi: 10.3389/fonc.2020.565820
Error in Figure/Table
In the published article, there was an error in Figure 3E as published. The representative picture of western blot bands of cleaved PARP1 of H446 cells were presented incorrectly. The corrected Figure 3E and its caption appear below.
FIGURE 3
Figure 3 The combination effects of JQ1 and BMN673 in SCLC cells. (A–D) CellTiter-Glo Luminescent assays demonstrating the effects of JQ1 and BMN673 as single agents or in combination in MYC paralog-dependent (A), independent (B) SCLC cells, DMS53 cells with c-MYC knockdown (C), and SHP77 cells with c-MYC overexpression (D). A mathematical model was applied to calculate the combination index using the CalcuSyn software program. (E) Western blot analysis of cleaved PARP and MYC paralogs in SCLC cells treated with BMN673 or JQ1 alone or in combination for 24 h. c-MYC for H82, H446 and DMS273, MYCN for H526 and H69, MYCL for H1963. (F), Western blot analysis of cleaved PARP and c-MYC in SHP77 cells with c-MYC overexpression followed by BMN673 and JQ1 treatment alone or in combination for 24 h. GAPDH was used as a loading control. (G) Tumor sphere structures in 3D matrigel were captured under a phase-contrast microscope upon treatment of JQ1 and BMN673 as single agents or in combination for 10 to 15 days. Representative images of tumor spheres were shown in the top panel. Quantification of scored tumor sphere structures (disintegrated, semi-disintegrated, and intact) was shown in the bottom panel. Scale bar, 40 μm. (H) 3D matrigel assays showing the effect of JQ1 and BMN673 in SHP77 cells with or without c-MYC overexpression. 1, Vehicle; 2, BMN673; 3, JQ1; 4, JQ1+BMN673.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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Keywords: small cell lung cancer, MYC paralog, PARP1, BET, DNA damage response
Citation: Bian X, Wang X, Zhang Q, Ma L, Cao G, Xu A, Han J, Huang J and Lin W (2023) Corrigendum: The MYC paralog-PARP1 axis as a potential therapeutic target in MYC paralog-activated small cell lung cancer. Front. Oncol. 13:1192526. doi: 10.3389/fonc.2023.1192526
Received: 23 March 2023; Accepted: 27 March 2023;
Published: 12 April 2023.
Edited and Reviewed by:
Shiv K. Gupta, Mayo Clinic, United StatesCopyright © 2023 Bian, Wang, Zhang, Ma, Cao, Xu, Han, Huang and Lin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Wenchu Lin, wenchu@hmfl.ac.cn