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REVIEW article

Front. Oncol.
Sec. Molecular and Cellular Oncology
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1375190
This article is part of the Research Topic Vascular Co-option and Beyond for Cancer Biology - Volume II View all articles

Exploring Vasculogenesis in the Normal Human Kidney and Clear Cell Renal Cell Carcinoma: Insights from Development to Tumor Progression and Biomarkers for Therapy Response

Provisionally accepted
Andrei A. Cosma Andrei A. Cosma 1Mihaela P. Fenesan Mihaela P. Fenesan 2,3,4Alexandru Nesiu Alexandru Nesiu 5Eugen Melnic Eugen Melnic 6Adela M. Ferician Adela M. Ferician 7Ovidiu C. Ferician Ovidiu C. Ferician 8Emil Ceban Emil Ceban 6Simona Sarb Simona Sarb 9Anca Maria Cimpean Anca Maria Cimpean 10*
  • 1 Division of Histology, Department of Microscopic Morphology, Faculty of Medicine, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania
  • 2 Department of Microscopic Morphology/Histology, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania
  • 3 OncoHelp Hospital, Timisoara, Romania
  • 4 Doctoral School in Medicine, Victor Babes University of Medicine and Pharmacy, Timisoara, Romania
  • 5 Faculty of Medicine, Vasile Goldiș Western University of Arad, Arad, Romania
  • 6 Nicolae Testemiţanu State University of Medicine and Pharmacy, Chișinău, Moldova
  • 7 Medlife Medicis Clinics, TIMISOARA, Romania
  • 8 Department of Orthopedy and Traumatology/Urology, Victor Babes University of Medicine and Pharmacy, TIMISOARA, Romania
  • 9 Faculty of Medicine, Victor Babes University of Medicine and Pharmacy Timisoara, Timisoara, Romania
  • 10 Microscopic Morphology/Histology, Victor Babes University of Medicine and Pharmacy, Timisoara, Timis, Romania

The final, formatted version of the article will be published soon.

    Vasculogenesis, which refers to the development of blood vessels from precursor cells, is a process that occurs predominantly during early embryonic life. It plays a crucial role in the establishment of the primitive vascular network. Vasculogenesis diminishes throughout the fetal vascular remodeling process, giving way to angiogenesis, which becomes the predominant mechanism after birth. At first, the development of the kidney's blood vessels depends on vasculogenesis, and then both vasculogenesis and angiogenesis happen simultaneously. Both processes are necessary for the normal development of the renal vasculature. Although the kidneys are highly vascularized, our understanding of normal kidney vasculogenesis is still incomplete. This lack of knowledge may explain the limited data available on the role of vasculogenesis in the progression and spread of renal cancers.

    Keywords: vasculogenesis, endothelial progenitor cells, clear cell renal cell carcinoma (cc RCC), metastases, Tumor Microenvironment, Blood Vessels

    Received: 23 Jan 2024; Accepted: 26 Mar 2024.

    Copyright: © 2024 Cosma, Fenesan, Nesiu, Melnic, Ferician, Ferician, Ceban, Sarb and Cimpean. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Anca Maria Cimpean, Microscopic Morphology/Histology, Victor Babes University of Medicine and Pharmacy, Timisoara, 300041, Timis, Romania

    Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.