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ORIGINAL RESEARCH article

Front. Oncol.
Sec. Gastrointestinal Cancers: Colorectal Cancer
Volume 14 - 2024 | doi: 10.3389/fonc.2024.1397468
This article is part of the Research Topic Advances in Proctology and Colorectal Surgery Volume II View all articles

Predicting Treatment Failure in Stage III Colon Cancer Patients After radical surgery Author information

Provisionally accepted
Hao Zeng Hao Zeng 1Xuejing Zhong Xuejing Zhong 2Wenxin Liu Wenxin Liu 3Baofeng Liang Baofeng Liang 3Xueyi Xue Xueyi Xue 3Nong Yu Nong Yu 3Dongbo Xu Dongbo Xu 1Xiaojie Wang Xiaojie Wang 4Shuangming Lin Shuangming Lin 1*
  • 1 Department of Gastrointestinal Surgery, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian Province, China
  • 2 Department of Science and Education, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian Province, China
  • 3 Longyan First Hospital Affiliated to Fujian Medical University, Longyan, Fujian, China
  • 4 Department of Colorectal Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian Province, China

The final, formatted version of the article will be published soon.

    The aim to assess treatment failure in patients with stage III colon cancer who underwent radical surgery and was analysed using the nomogram.: Clinical factors and survival outcomes for stage III colon cancer patients registered in the SEER database from 2018 to 2019 were analyzed, with patients split into training and testing cohorts (7:3 ratio). A total of 360 patients from the First Affiliated Hospital of Longyan served as an external validation cohort. Independent predictors of treatment failure were identified using logistic regression analyses. The nomograms was evaluated by concordance index (C-index), calibration curves, and the area under the curve (AUC), decision curve analysis (DCA) and clinical impact curves (CIC) assessed the clinical utility of nomograms versus TNM staging. Results: The study included 4,115 patients with stage III colon cancer. Multivariate logistic analysis age, tumor site, pT stage, pN stage, chemotherapy, pretreatment CEA levels, number of harvested lymph nodes, perineural invasion and marital status were identified as independent risk factors for treatment failure. The C-indices for the training and testing sets were 0.853 and 0.841. Validation by ROC and calibration curves confirmed the stability and reliability of the model. DCA showed that the net clinical effect of the histogram was superior to that of the TNM staging system, while CIC highlighted the potentially large clinical impact of the model.The developed Nomogram provides a powerful and accurate tool for clinicians to assess the risk of treatment failure after radical surgery in patients with stage III colon cancer.

    Keywords: Stage III colon cancer, Treatment Failure, nomogram, Epidemiology, And End Results(SEER), TNM staging systems

    Received: 07 Mar 2024; Accepted: 25 Apr 2024.

    Copyright: © 2024 Zeng, Zhong, Liu, Liang, Xue, Yu, Xu, Wang and Lin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

    * Correspondence: Shuangming Lin, Department of Gastrointestinal Surgery, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian Province, China

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