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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.00993

A Systematic evaluation of a group of Chinese patent medicines suggests that mixed herbs and chemicals may cause multiple organ damage

 xin y. Liu1 and  Yan Zhu1, 2, 3*
  • 1Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, China
  • 2Tianjin International Joint Academy of Biomedicine, China
  • 3Molecular Cardiology Research Institute, Tufts Medical Center, Tufts University School of Medicine, United States

Blood-activating and stasis-removing medicines (BASRMs)is a widely prescribed chinese patent medicines for cerebral and cardiovascular diseases in China. However, its safety effects on body and the underlying mechanisms remain unknown. Taking an integrated approach of tissue level and cell level analysis, we compared morphological characteristics of tissue to screen for toxic characteristics by H9C2 cells,HepG2 cells and HEK293 cells.In the animal experiment, Adriamycin was injected intraperitoneally with 2.5 mg / ml as a positive drug.Naoluotong capsule (NLTC) at 7.8mg and 39mg/20g by gavage. Besides, NLTC at 7.8mg and 39mg/20g also markedely reduced the levels of crea in serum. Chemical analysis by HPLC revealed that the topperidone hydrochloride has a tenth of the total drug, methyl hesperidin has 1/50,vitamin B6 has 1/250. The 3 chemical monomers were evaluated for activity at the cellular level.In conclusion, our study showed that the chinese patent medicine composed of chinese herbal medicines of BASRMs is safer than the chinese and western compound preparations, and the toxicity of the chinese and western compound preparations may mainly come from the chemical monomer tolperisone hydrochloride.Patients who used chinese and western compound preparations should take rational medicine under the guidance of doctors, pay attention to the dosage and avoid adverse reactions .NLTC side effect mechanism need further study.

Keywords: Blood-activating and stasis-removing medicines, the chinese and western compound preparations, side effect, organ damage, Toxicity

Received: 26 Nov 2018; Accepted: 05 Aug 2019.

Copyright: © 2019 Liu and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Yan Zhu, Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China,