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Review ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Pharmacol. | doi: 10.3389/fphar.2019.01336

Molecular Mechanisms of Action of Genistein in Cancer: Recent Advances

  • 1Maharishi Markandeshwar University, Mullana, India
  • 2Damanhour University, Egypt
  • 3Other, Estonia
  • 4Maharishi Markandeshwar University, Sadopur, India
  • 5Central University of Punjab, India
  • 6Lake Erie College of Osteopathic Medicine, United States

Background: Genistein is one among the several other known isoflavones that can be found in different soybeans and soy products. The chemical name of genistein is 4',5,7-trihydroxyisoflavone. Genistein has drawn attention of scientific community because of its potential beneficial effects on human dreadful diseases, such as cancer. Mechanistic insight of genistein reveals its potential for apoptotic induction, cell cycle arrest, as well as anti-angiogenic, antimetastatic and anti-inflammatory effects.
Objective: The purpose of this review is to unravel and analyze various molecular mechanisms of genistein in diverse cancer models.
Data sources: English language literature was searched using various databases, such as PubMed, ScienceDirect, EBOSCOhost, Scopus, Web of Science and Cochrane library. Key words used in various combinations included genistein, cancer, anticancer, molecular mechanisms prevention, treatment, in vivo, in vitro, and clinical studies.
Study selection: Study selection was carried out strictly in accordance with the statement of Preferred Reporting Items for Systematic Reviews and Meta-Analyses.
Data extraction: Four authors independently carried out the extraction of articles.
Data synthesis: 79 papers were found suitable to use in this review.
Conclusion: This review covers various molecular interactions of genistein with various cellular targets in cancer models. It will help the scientific community understand genistein and cancer biology and will provoke them to design novel therapeutic strategies.

Keywords: Genistein, Cancer, proliferation, Apoptosis, metastasis, in vitro, in vivo

Received: 05 Aug 2019; Accepted: 18 Oct 2019.

Copyright: © 2019 Tuli, Tuorkey, Thakral, Sak, Kumar, Sharma, Sharma, Jain and Bishayee. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Anupam Bishayee, Lake Erie College of Osteopathic Medicine, Bradenton, United States, abishayee@gmail.com