Lixin Chen
Wei Liang
*The final, formatted version of the article will be published soon.
ORIGINAL RESEARCH article
Front. Pharmacol.
Sec. Experimental Pharmacology and Drug Discovery
Volume 15 - 2024 |
doi: 10.3389/fphar.2024.1206718
This article is part of the Research Topic Pharmacometabolomics: An Omics Approach Towards the Identification of Novel Therapeutic Targets for Personalized Medicine View all 4 articles
To elucidate the mechanism of "Scrophulariae Radix-Fritillaria" in Goiter by integrated metabolomics and serum pharmacochemistry
Provisionally accepted- School of Pharmacy, Harbin University of Commerce, Harbin, Heilongjiang Province, China
The pharmacodynamic substances in "Scrophulariae Radix-Fritillaria" and the molecular mechanisms underlying its therapeutic effects against goiter were analyzed through metabolomics and serum pharmaco-chemistry. A rat model of goiter was established using PTU, and the animals were treated with "Scrophulariae Radix-Fritillaria". The efficacy of the drug pair was evaluated in terms of thyroid gland histopathology and blood biochemical indices. The serum and urine samples of the rats were analyzed by UPLC-Q-TOF/MS.
Keywords: "Scrophulariae Radix-Fritillaria" drug pair, Goiter, Metabolomics, Serum pharmacochemistry, UPLC-Q-TOF/MS
Received: 16 Apr 2023; Accepted: 17 Apr 2024.
Copyright: © 2024 Chen, Liang, Zhang, Wang, Li and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wei Liang, School of Pharmacy, Harbin University of Commerce, Harbin, Heilongjiang Province, China
Kun Zhang, School of Pharmacy, Harbin University of Commerce, Harbin, Heilongjiang Province, China
Zishuo Wang, School of Pharmacy, Harbin University of Commerce, Harbin, Heilongjiang Province, China
Wei C. Li, School of Pharmacy, Harbin University of Commerce, Harbin, Heilongjiang Province, China
Wenlan Li, School of Pharmacy, Harbin University of Commerce, Harbin, Heilongjiang Province, China
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