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Front. Psychiatry | doi: 10.3389/fpsyt.2018.00458

Association of the synapse-associated protein 97 (SAP97) gene polymorphism with neurocognitive function in schizophrenic patients

 Xusan Xu1, Chunmei Liang2, Dong Lv2, Jingwen Yin2, Xudong Luo2,  Jiawu Fu1, Haifeng Yan2, Xia Zhou1, Zhun Dai2, Dongjian Zhu2, Susu Xiong2, Zhixiong Lin2, Juda Lin2,  Bin Zhao1, You Li1, Yajun Wang2*, Guoda Ma2* and Keshen Li2*
  • 1Guangdong Medical University, China
  • 2Affiliated Hospital of Guangdong Medical University, China

The SAP97 gene is located in the schizophrenia susceptibility locus 3q29, and it encodes a synaptic scaffolding protein that interacts with the N-methyl-D-aspartate (NMDA) receptor, which is presumed to be dysregulated in schizophrenia. In this study, we genotyped a single-nucleotide polymorphism (SNP) (rs3915512) in the SAP97 gene in 1114 patients with schizophrenia and 1036 healthy-matched controls in a Han Chinese population through the improved multiplex ligation detection reaction (imLDR) technique. Then, we analyzed the association between this SNP and the patients’ clinical symptoms and neurocognitive function. Our results showed that there were no significant differences in the genotype and allele frequencies between the patients and the controls for the rs3915512 polymorphism. However, patients with the rs3915512 polymorphism TT genotype had higher neurocognitive function scores (list learning scores, symbol coding scores, category instances scores and controlled oral word association test scores) than the subjects with the A allele (P = 4.72 × 10-5, 0.027, 0.027, 0.013,respectively). Our data are the first to suggest that the SAP97 rs3915512 polymorphism may affect neurocognitive function in patients with schizophrenia.

Keywords: Schizophrenia, Synapse-associated protein 97 (SAP97) gene, L27 domain, rs3915512 polymorphism, neurocognitive function

Received: 14 Jul 2018; Accepted: 04 Sep 2018.

Edited by:

Błażej Misiak, Wroclaw Medical University, Poland

Reviewed by:

Antonio Bruno, Università degli Studi di Messina, Italy
Napoleon Waszkiewicz, Department of Psychiatry, Medical University of Białystok, Poland  

Copyright: © 2018 Xu, Liang, Lv, Yin, Luo, Fu, Yan, Zhou, Dai, Zhu, Xiong, Lin, Lin, Zhao, Li, Wang, Ma and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence:
Prof. Yajun Wang, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China,
Prof. Guoda Ma, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China,
Prof. Keshen Li, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong Province, China,