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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Psychiatry | doi: 10.3389/fpsyt.2019.00711

CROSS-VALIDATION OF PARANOID-DEPRESSIVE SCALE AND FUNCTIONAL MRI: NEW PARADIGM FOR NEUROSCIENCE INFORMED CLINICAL PSYCHOPATHOLOGY

  • 1Department of Psychiatry and Medical Psychology, Plovdiv Medical University, Bulgaria
  • 2Plovdiv Medical University, Bulgaria
  • 3University of Basel, Switzerland

There is reported a study performed with a novel paradigm aiming at investigation of the translational validity of von Zerssen’s paranoid-depression scale and its fMRI correlates in terms of focus on exploration of the results on the contrast between the Paranoid Specific (DP) blocks and the Depression Specific (DS) blocks. Patients with schizophrenia demonstrated significant activations in a number of regions (right angular gyrus, left posterior cingulate and precuneus, right transverse temporal gyrus) during responses to paranoia versus depression items which differ topologically from those found in patients with major depression (left middle cingulate and right superior temporal gyrus). The direct comparison between the groups, however, did not yield any residual activations after correction.

Keywords: functional MRI, Depression, Scizophrenia , Validation, Psychopatalogy

Received: 11 Jul 2019; Accepted: 05 Sep 2019.

Copyright: © 2019 Stoyanov, Kandilarova, Arabadzhiev, Paunova, Schmidt and Borgwardt. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Prof. Drozdstoy S. Stoyanov, Plovdiv Medical University, Department of Psychiatry and Medical Psychology, Plovdiv, 4002, Bulgaria, dstoyanov@meduniversity-plovdiv.bg