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BRIEF RESEARCH REPORT article

Front. Psychiatry, 24 April 2024
Sec. Psychological Therapy and Psychosomatics

Assessing the patient’s affective perception of their psychotherapist: validation of the in-Session Patient Affective Reactions Questionnaire

Alberto Stefana,*Alberto Stefana1,2*Paolo Fusar-Poli,,Paolo Fusar-Poli1,3,4Eduard VietaEduard Vieta5Eric A. Youngstrom,,Eric A. Youngstrom2,6,7
  • 1Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy
  • 2Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States
  • 3OASIS Service, South London and Maudsley NHS Foundation Trust, London, United Kingdom
  • 4Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom
  • 5Bipolar and Depressive Disorders Unit, Hospital Clinic, Institute of Biomedical Research Agusti Pi i Sunyer (IDIBAPS), Centro de Investigacio Biomédica en Red de Salud Mental (CIBERSAM), University of Barcelona, Barcelona, Spain
  • 6Institute for Mental and Behavioral Health Research, Nationwide Children’s Hospital, Division of Child and Family Psychiatry, The Ohio State University, Columbus, OH, United States
  • 7Helping Give Away Psychological Science, Chapel Hill, NC, United States

Background: Psychotherapists need effective tools to monitor changes in the patient’s affective perception of the therapist and the therapeutic relationship during sessions to tailor therapeutic interventions and improve treatment outcomes. This study aims to evaluate the factor structure, reliability, and validity of the in-Session Patient Affective Reactions Questionnaire (SPARQ), a concise self-report measure designed for practical application in real-world psychotherapy settings.

Methods: Validation data was gathered from (N = 700) adult patients in individual psychotherapy. These patients completed the SPARQ in conjunction with additional measures capturing sociodemographic details, characteristics of therapeutic interventions, individual personality traits, mental health symptom severity, elements of the therapeutic relationship, and session outcomes. This comprehensive approach was employed to assess the construct and criterion-related validity of the SPARQ.

Results: The SPARQ has a two-factor structure: Positive Affect (k = 4, ω total = .87) and Negative Affect (k = 4, ω total = .75). Bifactor confirmatory factor analysis (CFA) yielded the following fit indices: X2[df] = 2.53, CFI = .99; TLI = .98; RMSEA = .05; and SRMR = .02. Multi-group CFAs demonstrated measurement invariance (i) across patients who attended psychotherapy sessions in person versus in remote mode, and (ii) across patients with and without psychiatric diagnoses confirmed metric invariance. Furthermore, the SPARQ showed meaningful correlations with concurrently administered measures.

Discussion: The SPARQ proves to be a valuable instrument in clinical, training, and research contexts, adept at capturing patients’ session-level affective responses towards their therapist and perceptions of the therapeutic alliance. Comprehensive descriptive statistics and a range of score precision indices have been reported, intended to serve as benchmarks for future research.

1 Introduction

Emotions are a fundamental component of the human experience. They are the result of an evolutionary process aimed at helping people mobilize their organism to deal with important interpersonal encounters and, more generally, with fundamental life tasks (1, 2). Therefore, it is not surprising that emotions have been considered therapeutically significant since the origins of psychotherapy (3), whether they were part of the clinical manifestation of the patient or part of the therapist’s experience in the therapeutic effort to help them (4).

1.1 A brief historical background

Historically, the phenomenon of the emotions experienced by a patient towards their clinician was first theoretically conceptualized by Sigmund Freud, who introduced the term transference towards the end of the 19th century (5). Freud described transference as the redirection of a patient’s feelings, fantasies, desires, and even entire scenarios, which are re-enactments of past psychological experiences with significant figures from childhood, onto the clinician. He identified two coexisting forms of transference: positive transference, which involves conscious affectionate feelings, and negative transference, which encompasses hostile feelings that usually remain unconscious.

Building on Freud’s work, psychoanalyst Melanie Klein and her colleagues expanded the definition of transference in the second half of the 20th century (6). They viewed it as both a conscious and unconscious manifestation of past and present experiences, relationships, emotions, thoughts, and fantasies, encompassing both positive and negative aspects in relation to the clinician. This broader interpretation was termed the ‘total situation,’ and aimed to include all facets of the patient’s relationship with the clinician in the concept of transference (7).

In contemporary understanding, transference is generally recognized by clinicians and researchers as a pattern of enduring emotions, thoughts, motivations, and behaviors that are activated and displayed in the patient’s relationship with the therapist (8, 9). Based on this conceptualization of the construct, we developed the in-Session Patient Affective Reactions Questionnaire (SPARQ) (10) to measure in a self-report format patterns of affective, cognitive, and behavioral responses experienced by a patient toward their therapist during an individual psychotherapy session.

1.2 Pantheoretical nature of the in-session emotions

Many clinicians believe that one of the main differences between analytic and nonanalytic psychotherapies lies in the theoretical and clinical attention the former place upon transference. This is one of the most common and persistent misconceptions, particularly about CBT (1113). In fact, Aaron Beck (14), discussing similarities and differences between cognitive therapy and psychoanalysis, maintained that the former ‘has access to the types of ideational material obtained in free association, dream reporting, and in the patient’s reactions to the therapist (transference). However, by staying close to the data, the therapist avoids becoming enmeshed in the abstract speculation of psychoanalysis’.

It is worth noting that leading theoreticians of nearly all of the major psychotherapeutic approaches acknowledge that the phenomenon psychoanalysts call transference exists in their therapies, although they might name it differently and vary markedly in how clinically important they consider it, as well as in if and how it should be dealt with (15). Transference has been documented by such authors as Carl Rogers (16), within the client-centered therapy, Fritz Perls (17), within gestalt therapy, and Rollo May (18) within existential therapy. In the CBT model, Beck (14, 19) talked explicitly of transference, Goldfried and Davison (20) described it in terms of ‘parataxic distortion.’ Other CBT therapists define it as overgeneralization (21). Francine Shapiro (22) underlines that the decision to proceed with EMDR in case of a patient’s dissociative disorder depends, among other factors, on the therapist’s ability to anticipate and accommodate transferences.

1.3 Emotional expression in psychotherapy

Research on emotional expression in psychotherapy provides evidence that emotions substantially contribute to therapy outcomes at both the session and treatment levels (2325). Furthermore, emotions are an element of both therapy-specific and nonspecific therapeutic processes related to clinical efficacy (26, 27). Helping patients become aware of their emotions and make constructive use of them appears to be important in therapeutic change (28, 29). To achieve this therapeutic result, the therapist has to collaboratively focus on the emotions experienced by the patient during the session, helping them to recognize, feel, tolerate, explore, accept, regulate, make sense of, transform, and manage these emotions (30).

Therapy can reactivate repressed or denied emotions, allowing the patient to recover undesired experience, and activate new emotions. Both situations give therapy participants information about the patient’s needs and responses to specific intrapsychic and interpersonal situations, and thus represent an opportunity to work through previously denied and dreaded feelings and incorporate new experiences into those generated in the past (31). This helps patients transform their persistent memory-based problematic implicit emotional procedures and, in turn, change their patterns of interactions with the environment (32). Among all the emotions experienced by a patient in the ‘here and now’ of the therapeutic session, those felt toward the therapist are particularly important and useful for fulfilling or facilitating the therapeutic work just described (33, 34). An empathic and affirming therapeutic relationship is a pivotal factor in whether emotional experience and expression are productive versus negative for therapy (24). It is both a key ingredient in change and a prerequisite for the effective implementation of psychotherapeutic work (35).

Therefore, therapists need to monitor (assess) even small changes in the patient’s affective perception of the therapeutic relationship as they occur to address and repair the relationship. Without assessing the perception of the patient, one cannot intervene promptly and appropriately. Although various measures have been developed to assess emotions and emotional expression – both as state and trait constructs [DES (36), PANAS (37), POMS (38, 39)] – and several have been used in the context of psychotherapy research (24, 40), only a few of them formally incorporate attention to affective processes in dyadic therapy relationships. Currently, the few existing psychological assessment tools that measure patients’ emotional reactions towards their therapists are primarily therapist-rated. These tools assess transference in the narrow sense, as defined by Freud (e.g., 41, 42), or in the broader sense of the ‘total situation’ (e.g., 43). However, studies investigating this phenomenon from the patient’s perspective have utilized scales not specifically designed for examining response patterns within the psychotherapeutic setting or are length (e.g., 44). For example, the Psychotherapy Relationship Questionnaire (43) is a clinician-report scale that measures the same construct as SPARQ, but it is composed of 90 items and assesses affective reactions over a time frame of approximately eight sessions. Existing self-report measures that capture constructs such as alliance (45, 46) or alliance rupture (47) only indirectly include affective content.

To fill this gap, we wrote a large item set focusing on affective responses during the psychotherapy session. The initial pool contained more than 130 items. We revised based on expert review, and then used a sequence of exploratory and confirmatory factor analyses to understand the dimensionality. Item response theory analyses then selected the items providing the most information for each factor, resulting in the two four-item subscales that we are evaluating in terms of construct validity in the present study (10).

1.4 Aim

The purpose of the current study is to validate a brief self-report measure of the patterns of thought, feeling, and behavior experienced in session by the patient toward their therapist, which is clinically sophisticated, pantheoretical, and feasible to be administered in a real-world psychotherapy setting.

Specific aims included selecting items that balanced brevity, in order to improve tolerability and reduce missing data or reactance (48, 49), while also looking at item characteristics to improve information value when dyads start to experience affective reactions. We also aimed to develop balanced scales for positive and negative valenced affect, and we calculated person-centered benchmarks for clinically significant changes in scores (50, 51). Provided that the other evidence of construct validity appears sufficient, these patient-centered benchmarks provide a good foundation for clinical use. We extended our prior work by also testing a bifactor model to see if it provided better fit, indicating that the subscales might represent distinct but related constructs [as has been shown with the subscales of the RRI (52)]. Because our data collection happened after the COVID pandemic (53), we had an opportunity to compare whether the scales showed comparable psychometrics when used for in-person versus online therapy. We tested this ancillary aim through progressive structural invariance model comparisons (54).

We examined several aspects of construct validity by looking at correlations with demographic feature such as age, sex, ethnicity, and education (all expected to have small, often nonsignificant correlations with session-level affective response, e.g., |r| ~ .2 or smaller), as well as clinical diagnoses that were the focus of treatment, and session parameters. These were expected to also be small, in as much as the items were designed to be session-focused.

Construct validity was further explored by examining correlations with the ‘big five’ personality traits (where we anticipated moderate positive correlations between positive affect and extraversion and agreeableness, and moderate positive correlation between trait negative emotionality/neuroticism and session-level tendencies towards negative affect) (55), and moderate correlations with self-functioning and interpersonal functioning. We also included state measures of affect, as well as widely used scales of depressive and anxious symptoms. A large body of work on the tripartite model of depression and anxiety indicates that these types of scales share a common dimension of negative, whereas depression also includes low positive affect features such as anhedonia and loss of interest (although depression scales frequently under-represent the low-PA content, increasing the apparently overlap with NA and thus with anxiety). Because these also are state scales, and because they are dimensional instead of discrete yes/no items, we hypothesized that correlations would be larger than observed with diagnoses, but still moderate sized (r values in the.3 range).

Finally, we also examined convergent validity with measures of therapeutic relationship, including working alliance, real relationship genuineness and realism, and session outcome ratings. Here we expected large correlations (r > .5, but ideally < .85, or else more than 70% of the variance would be shared, raising the question of whether the measures were redundant) (56, 57).

2 Methods

2.1 Recruitment

The target population was adult patients fluent in English with heterogeneous mental conditions and in different types and timings of psychotherapeutic treatment. Participants were recruited via two online patient registers, i.e., Research for Me ResearchMatch, from March through April 2023. After providing informed consent, they completed a one-time battery of measures implemented on Qualtrics software. This research was approved by the Institutional Review Board of the University of North Carolina at Chapel Hill (Study #: 23-0216; Approval Date: 3/06/2023). Online informed consent was provided by all participants.

2.2 Participants

The sample was composed of 700 adult psychotherapy patients. Most (81%, n = 564) were female. The most common age range was 30 to 39 years (28%, n = 193), followed by 23 to 29 years (20%, n = 142). Most participants had a psychiatric diagnosis (84%, n = 590). The most prevalent DSM diagnosis among the participants was anxiety disorder (66%, n = 464), followed by unipolar depressive disorder (56%, n = 391) and trauma- and stressor-related disorders (35%, n = 244). Approximately half of the subjects had three or more diagnoses at the diagnostic category level (51%, n = 302), one-third had two diagnoses (31%, n = 185), and the remainder had a single diagnosis (18%, n = 103). A significant portion of patients had been in psychotherapy for over 24 months (47%, n = 332), with most attending two to four sessions per month (77%, n = 543). Over half of the participants (53%, n = 369) conducted their most recent session via video call. Table 1 reports sample sociodemographic, clinical, and treatment characteristics. All information, including psychiatric diagnosis, was self-reported.

Table 1
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Table 1 Demographics, clinical, and treatment characteristics of participating patients (N = 700).

2.3 Measures

A battery designed to evaluate convergent and discriminant validity included measures of patient characteristics, personality traits, mental health status, aspects of the therapeutic relationship, and session outcome. The ‘sociodemographic, clinical, and treatment domain’ collects information about the sociodemographic and clinical characteristics of the patient, as well as the psychotherapeutic treatment they receive. The ‘trait domain’ focuses on individual personality traits. The ‘mental health state domain’ encompasses measures of symptoms that impact the daily lives of participants. These three domains are used to evaluate discriminant validity. The ‘therapeutic relationship domain’ provides insights into the nuances of the patient-therapist relationship from the patient’s perspective, crucial for assessing the convergent validity. Finally, the measure of the ‘session outcome domain’ is instrumental in determining predictive validity. We prioritized previously validated short forms where available to reduce respondent burden, increasing participation rates and data completeness, in keeping with best practices (58).

2.3.1 Sociodemographic, clinical, and treatment domain

The participants completed an 11-item sociodemographic and clinical data form, which recorded the information listed in Table 1.

2.3.2 Trait domain

2.3.2.1 Big Five Inventory–2-Extra-Short form

The BFI-2-XS (59) is a 15-item self-administrated scale used to assess personality at the level of the Big Five domains (three items for each domain). Items are rated on a 5-point Likert scale ranging from 1 = ‘Disagree strongly’ to 5 = ‘Agree strongly.’ In our internal consistency analysis, average inter-item correlations were .34 for the Extraversion dimension, .27 for the Agreeableness dimension, .38 for the Conscientiousness dimension, .35 for the Negative Emotionality dimension, and .25 for the Open-Mindedness dimension. The BFI-2-XS has been used extensively, with more than 800 citations in Google Scholar at the time of preparing this paper.

2.3.2.2 The Level of Personality Functioning Scale-Brief Form 2.0

The LPFS-BF 2.0 (60) is a 12-item self-report questionnaire for the assessment of the severity of personality pathology. It assesses impairment in self-functioning and interpersonal functioning based on levels of personality functioning described in Section III of DSM-5. Ratings are made on a 5-point Likert scale, ranging from 1 = ‘Completely untrue’ to 4 = ‘Completely true.’ Higher scores indicate greater impairment. The Cronbach’s alpha coefficient for our sample was.85.

2.3.3 Mental health state domain

2.3.3.1 International Positive and Negative Affect Schedule – Short Form

The I-PANAS-SF (61) is a 10-item self-report measure of the frequency with which the respondent has experienced positive (5 items) and negative (5 items) affects during the last week. The ten emotional adjectives are rated on a five-point Likert scale ranging from 1 = ‘Very slightly or not at all’ to 5 = ‘extremely’). Higher scores indicate strong emotional activation. Reliability coefficients in our sample were alpha = .78 for the Positive Affect scale and = .74 for the Negative Affect scale.

2.3.3.2 Patient Health Questionnaire-9

The PHQ-9 (62) is a 9-item self-administered depression screening scale that can be used to measure depression severity also based on the DSM-5 criteria (63). Items are rated on a 4-point Likert scale ranging from 0 = ‘Not at all’ to 3 = ‘Nearly every day.’ In this study, we investigated the frequency with which patients had experienced each of the nine symptoms of depression during the past 7 days. Higher scores indicate more severe depressive symptoms. Internal consistency in our sample for this measure was alpha = .86.

2.3.3.3 Generalized Anxiety Disorder-7

The GAD-7 (64) is a 7-item self-report measure of the presence and severity of generalized anxiety disorder. Each item is scored 0 = ‘Not at all’ to 3 = ‘Nearly every day.’ We assessed the patient’s health status during the previous 7 days. Higher scores indicate more severe anxiety. Reliability in our study was alpha = .88.

2.3.3.4 Single-item global measures of symptom severity, psychosocial functioning, and quality of life

The three single-item measures of symptom severity, psychosocial functioning, and quality of life developed by Zimmerman et al. (65) was adapted for this study. More specifically, the term ‘symptoms of depression’ was replaced by ‘symptoms for which you are in psychotherapeutic treatment.’ The item on symptom severity is rated on a 5-point Likert scale ranging from 0 = ‘None’ to 4 = ‘Severe.’ The psychosocial functioning item Likert scale ranges from 0 = ‘Not at all’ to 4 = ‘Extremely.’ The responses to the quality of life item range from 0 = ‘Very good, my life could hardly be better’ to 4 = ‘Very bad, my life could hardly be worse’.

2.3.4 Therapeutic relationship domain

2.3.4.1 in-Session Patient Affective Reactions Questionnaire

The SPARQ (10) is an 8-item patient-report measure of patterns of thought, feeling, and behavior activated and experienced in the therapeutic relationship. It is composed of two sub-scales of four items each: Positive Affect (delineates a secure and comfortable – from the patient’s perspective – experience of the therapeutic relationship) and Negative Affect (which is marked by items describing feelings of shyness and shame with the therapist, fear of speaking openly, worry of not being helped, and failure due to their need for help from the therapist). Patients rate on a 5-point Likert scale ranging from 0 = ‘Not at all true’ to 4 ‘Very true.’ Higher scores indicated greater emotional response. Initial validation of the SPARQ showed internal consistency of alpha = .86 and .74 respectively for the Positive and the Negative Affect scales. The SPARQ has been included as an Appendix.

2.3.4.2 Working Alliance Inventory – Short Revised

The WAI-SR (66) is a 12-item self-report measure of the quality of the therapeutic alliance in the last session. It includes three subscales (four items each) that are: (a) agreement on the therapy’s tasks, (b) agreement on the therapy’s goals, and (c) development of a patient–therapist affective bond. Items are rated on a 6-point Likert scale ranging from 0 = ‘Not at all’ to 5 = ‘Completely.’ Higher scores indicate better alliance. Internal consistency in the current study was alpha = .95 for the total scale.

2.3.4.3 Real Relationship Inventory-Client short form

The RRI-C-SF (67) is an 8-item self-report measure of perception of the strength of the real relationship, that is ‘the personal relationship existing between two or more people reflected in the degree to which each is genuine with the other and perceives and experiences the other in ways that befit the other’ (68). It consists of two subscales: Genuineness (i.e., ‘the ability to be who one truly is, as opposed to being phony or inauthentic’) and Realism (i.e., ‘perceiving experiencing or the other in ways that befit him or her [rather than projections based on fears and wishes related to significant others from the past]’) (68). Ratings are made on a 5-point Likert scale, ranging from 1 = ‘Strongly disagree’ to 5 ‘Strongly agree.’ Higher scores reflect stronger real relationships. In our internal consistency analysis, the RRI-C-SF showed alpha = .91 for the total scale.

2.3.4.4 Post-Session Questionnaire

The part B of the PSQ (69) is a 4-single-item self-report measure of alliance ruptures and rupture resolution during the last therapy session. It consists of a gatekeeping-item exploring the occurrence (‘Yes’ or ‘No’) of any tension, conflict, problem, misunderstanding, or disagreement in the relationship with the therapist during the session, followed by three items assessing the highest degree of tension experienced (from 1 = ‘Low’ to 5 = ‘High’), the extent to which the problem was addressed in this session (from 1 = ‘Not at all’ to 5 = ‘Very much’), and the degree to which in the patient’s opinion the problem was resolved by the end of the session (from 1 = ‘Not at all’ to 5 = ‘Very much’).

2.3.5 Session outcome domain

2.3.5.1 Session Evaluation Scale

The SES (70) is a self-report 5-item subscale of the Helping Skills Measure (71) and assesses the patient’s perception of therapy session quality (which is a key aspect of the session outcome). Four items are rated on a 5-point Likert scale ranging from 1 = ‘Strongly disagree’ to 5 = ‘Strongly agree,’ while the fifth item scale ranges from 1 = ‘Very effective’ to 4 = ‘Ineffective.’ The score is obtained by summing the values of five items (after reversing the ones indicated) and then dividing by five. Higher scores indicate the perception of higher quality of the session. Reliability in our study was alpha = .86.

2.4 Data analysis

In the first step, Bartlett’s test of sphericity and Kaiser–Meyer–Olkin test were used to evaluate the suitability of the data for factor analysis. A confirmatory factor analysis (CFA) with robust maximum likelihood estimator was performed using the R package lavaan v0.6-12 (72) to test the fit of the two-factor model as identified in its validation study (10) – see the description in the Measure section. Multigroup CFA was performed using the R package lavaan to examine the measurement invariance of the SPARQ among patients who attended psychotherapy sessions in person (both face-to-face and on the couch) versus in remote mode (video and telephone calls). Furthermore, since the SPARQ was developed and preliminary validated using data from a sample completely composed of patients with psychiatric disorders, a multigroup CFA was conducted to examine the measurement invariance between patients with versus without a (self-reported) psychiatric diagnosis. In assessing CFA models fit, the following thresholds were considered: a comparative fit index (CFI) of .95 or greater, a Tucker Lewis index (TLI) of .95 or greater, a root mean square error of approximation (RMSEA) of .06 or less, and a standardized root mean square residual (SRMR) of .08 or less (73, 74). Graded response model (GRM) item response theory (IRT) models were employed using the R package mirt v1.37.1 (75) to get detailed information at the item level and to analyze option characteristics of the scale. To evaluate the psychometric properties of the SPARQ, the following statistical analyses were performed. Cronbach’s alpha and McDonald’s Omega total coefficients, as well as average inter-item r, were performed using the package psych v2.3.12 (76) to assess the internal consistency for each scale (49, 77). Correlations between subscales and (a) sociodemographic, clinical, and treatment variables and (b) validated measures of traits and state mental qualities of the patients, specific elements of the therapeutic relationship, and session outcome were calculated using the R package correlation v0.8.3 to provide criterion validity. Furthermore, pooled correlation matrices were averaged using Fisher’s z-transformation to produce an average inter-subtest correlation matrix for demographics, clinical (diagnoses), and treatment setting variables, as well as for traits, state, and therapeutic relationship measures scores. No missing data were present since the Qualtrics survey was set to force each response from the respondents. No missing data was encountered in the survey results, as the Qualtrics survey was configured to require respondents to answer each question, ensuring complete response data.

3 Results

3.1 Preliminary analyses

The Bartlett test of sphericity (χ²[45] = 2580, p < .001) and the Kaiser–Meyer–Olkin test (.87) supported data suitability for factor analysis.

3.2 Confirmatory factor analysis

The two-factor model showed good fit to the data: χ²[19] = 5.62, CFI = .96, TLI = .94, RMSEA = .08 (90% CI [.07, .10]), and SRMR = .05 (see Figure 1). A bifactor model with a general factor of affective reaction and two specific factors of positive affect and negative affect demonstrated excellent indices of fit: χ²(df = 12) = 30.30, CFI = .99; TLI = .98; RMSEA = .05 (90% CI [.03, .07]); and SRMR = .02.

Figure 1
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Figure 1 Measurement model from confirmatory factor analysis (N = 700) presenting fully standardized solution using robust maximum likelihood estimation. This figure presents abbreviated item content.

3.3 Invariance testing with multigroup CFA

Two multigroup CFA models were independently tested for measurement invariance between (a) patients attending in-person (either face-to-face or on the couch) and remote (via video or telephone call) sessions and (b) patients with or without a psychiatric diagnosis.

3.3.1 Session format

The analysis of configural invariance demonstrated a robust fit of the two-factor model, as indicated by a CFI of .995 and a TLI of.993 for the free model. These values suggest a consistent factor structure across both groups, confirming that the pattern of item-factor loadings is uniform. The RMSEA was .063, and the SRMR was.058, further supporting the good fit of the model. See Supplementary Material 1 for additional results.

Upon transition to metric invariance (weak model), there was a negligible shift in model fit. The ΔCFI was.000, indicating that there were no differences. The ΔTLI was +.001, moving from .993 to 0.994, and the ΔRMSEA was −.005, improving from .063 to .058. The ΔSRMR was +.002, reaching .060. These minimal changes suggest that the way items are weighted is largely consistent across groups.

Further analysis on scalar invariance (strong model) examined the equivalence of item intercepts across groups. In this phase, the model fit exhibited marginal alterations: ΔCFI remained virtually unchanged (+.001), resulting in a value of .996, while ΔTLI saw an increase of +.004 (from .993 to .997), and RMSEA improved, decreasing from .063 to .043. The SRMR value slightly increased reaching .060. These variations are not substantial.

The chi-square difference test comparing the weak and free models showed a nonsignificant difference (p = .640). Similarly, the comparison between the strong and free models did not show a significant difference (p = .480). These findings suggest that configural, metric, and scalar invariances are confirmed.

3.3.2 Diagnostic status

Analysis of configural invariance demonstrated a robust fit, as indicated by a CFI of .993, a TLI of .989, a RMSEA of .074, and a SRMR of .063 for the unconstrained (free) model. These values suggest a consistent factor structure across both groups, confirming that the pattern of item-factor loadings is uniform.

Upon transition to metric invariance (weak model), there was a negligible shift in model fit. The ΔCFI was −.001, indicating a slight decrease from .993 to .992. The ΔTLI was +.001 (an increase rather than a decrease), moving from .989 to .990, and the ΔRMSEA remained constant at .000, maintaining the value of .074. The ΔSRMR also remained unchanged at .063. These minimal changes suggest that the way items are weighted is largely consistent across groups, although a deeper examination might be beneficial to confirm this observation. See Supplementary Material 2 for additional results.

Further analysis on scalar invariance (strong model) examined the equivalence of item intercepts across groups. In this phase, the model fit exhibited marginal alterations: ΔCFI remained unchanged at .000, maintaining the value of .993, while ΔTLI saw a decrease of −.005 (from .989 to .984, not an increase to .994), and RMSEA improved, decreasing from .074 to .054. The SRMR saw a slight increase to .064. These changes suggest potential variations in the way items are interpreted between in-person and remote groups, although these variations are not substantial.

Finally, the chi-square difference tests comparing the free model with the weak and strong models provided significant insights. The comparison between the weak and free models was marginally significant (p = .057), suggesting a slight preference for the free model, while the comparison between the strong and free models did not show a significant difference (p = .360). In conclusion, while the analysis confirms configural invariance, it indicates less concern about metric and scalar invariance than initially anticipated. These findings suggest that the measurement and operationalization of constructs are largely similar between the two groups, with only minor differences that warrant further attention.

3.4 Item response theory

The items for the SPARQ scales were evaluated using Samejima’s graded response IRT model. For the Positive Affect scale, all four items demonstrated very high discrimination parameter values (>1.70). Similarly, the Negative Affect scale featured two items with high discrimination values (>1.35) and two with very high values (78). The Positive Affect scale demonstrated reliability >.80 from theta of −3.0 to +0.7. In contrast, the Negative Affect scale had reliability >.80 at theta ranging from +0.4 to +2.6. Table 2 details the item discrimination and difficulty parameters. Figure 2 shows the item characteristic curves and reliability for the scale scores.

Table 2
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Table 2 Item option characteristics for the three factors based on IRT models.

Figure 2
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Figure 2 Item option characteristic curves and reliability for the scale scores. The reliability curves, represented in the range of 0 to 1.0, depict how reliability estimates vary across different levels of the underlying factor, specifically at low (negative θ values), average (θ = 0), and high (positive θ) levels. On the right, the curves illustrate the thresholds at which the probability of a patient selecting a higher response option on an item increases.

3.5 Internal consistency and reliability

As can be seen in Table 3, both the Positive Affect (k = 4) and the Negative Affect (k = 4) scales were adequate in their internal consistency (49, 77) as measured by Cronbach alpha (.86 and .75, respectively), average inter-item r (.60 and .43, respectively), and McDonald omega total (.87 and .75, respectively).

Table 3
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Table 3 Descriptive statistics, internal consistency reliability, precision, and inter-scale correlations.

3.6 Score precision

The mean scores on Positive Affect and Negative Affect scales were, respectively, 12.26 (SD = 3.30) and 3.18 (SD = 3.13).

Table 3 reports the standard error of the measure, standard error of the difference, and reliable change indexes (79) as measures of score precision. Furthermore, clinical change benchmarks have been calculated. The 5th percentile of the Positive Affect score was estimated to determine which score should be considered alarmingly low compared to the observed population distribution, and the 95th percentile of the Negative Affect score to indicate which value should be considered alarmingly high. Lastly, estimates of the minimally important difference were provided as a criterion for what might be recognized as a meaningful shift in the patient’s affective tone.

3.7 Associations between SPARQ factors and sociodemographic, clinical, and treatment variables

Both the Positive and Negative Affect scales were very weakly correlated with the average correlation coefficients of demographics, clinical, and treatment variables. All individual correlations were very weak or weak, with rs ranging from −.20 to.20. Age, presence of any psychiatric disorder, and length of therapy were positively associated with the Positive Affect scale and negatively with the Negative Affect scale. Table 4 presents all computed correlation coefficients.

Table 4
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Table 4 Criterion validity correlations with patient demographics, diagnoses, and objective therapy characteristics.

3.8 Criterion validity

The Positive Affect scale was very weakly correlated with the average correlation coefficients of both the trait (BFI-2-XS and LPFS-BF 2.0, mean absolute r = .13) and state (PHQ-9, GAD-7, and I-PANAS-SF, mean absolute r = .16) measures, whereas it was strongly (≥ .60) (80) correlated with the absolute average correlation coefficients of the therapeutic relationship measures. Looking more closely at the correlations (see Table 5), we can see that the Positive Affect scale was very strongly correlated with the WAI-SR total score and bond subscale and strongly with the WAI-SR goal and task subscales, the SES (session outcome measure), and the PSQ item on the extent to which the problem/conflict/misunderstanding experienced in the session was addressed in the same session. Furthermore, it was moderately correlated with the RRI-C total score and subscales, and the PSQ item about the degree to which the problem experienced in the session was resolved during the same encounter. Lastly, the Positive Affect scale was moderately and negatively correlated with the PSQ item on the magnitude of tension perceived by the subject in response to the problem that occurred during the session.

Table 5
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Table 5 Criterion validity correlations with validated scales.

The Negative Affect scale was weakly correlated with the average correlation coefficients of both the trait and state measures, and moderately correlated with the average correlation coefficients of the therapeutic relationship measures. Looking at the individual correlations, we can see that the Negative Affect scale had no strong correlations, but was moderately correlated with the SES, the WAI-SR total score and subscales, and the RRI-C total score and subscales. Furthermore, it was moderately correlated with the PSQ item on the magnitude of tension experienced by the patient. The correlations between the SPARQ scales and all the measures of patients’ personality characteristics and current mental health state were weak (r ≤ .39) or very weak (r ≤ .19). Table 5 presents all computed correlation coefficients.

4 Discussion

In this study, our objective was to examine the reliability and validity of a new instrument intended to gather potentially clinically helpful information about affective reactions in the adult patient during individual psychotherapy sessions, the SPARQ. We evaluated this scale using factor analyses and item response theory.

Patient feedback (self- or other) feedback, despite its inherent biases and distortions (81, 82), is an important indicator of their inner experience during psychotherapy sessions. Conscious emotional processes, as reflected in such feedback, play a crucial role in enhancing therapy outcomes (83) and understanding the reasons for early termination of therapy (84). Additionally, patient-reported information provides an essential balance to therapist assessments, which may be skewed by biases in evaluating patient emotions and understanding. In fact, these biases contribute to approximately 30% of the variance in therapist ratings, even after considering perceived emotional intelligence (82). By incorporating patients’ views on their emotional responses, therapists gain access to what could be considered ‘objective data’ from the patient’s perspective. This approach not only provides more comprehensive information, but also helps to challenge negative interpersonal perceptions, foster deeper understanding, and strengthen the therapeutic alliance and outcomes. Studies on routine outcome monitoring in psychotherapy suggest that paying attention to patients’ emotional responses towards their therapists can be particularly beneficial for those struggling with therapy (8587). Furthermore, the practice of psychological assessment, when coupled with tailored feedback, can serve as a therapeutic tool in itself, producing significant positive effects on treatment processes (88). The SPARQ could signify an advanced progression in the field of measurement feedback systems, which are based on the employment of valid, reliable, and standardized methods to improve mental health treatment outcomes (89).

The two dimensions of the SPARQ reflect the emotional patterns that typically emerge in the context of psychotherapeutic practice (9093). This alignment enables therapists and researchers to effectively discern and monitor patient emotional responses towards their therapists. Additionally, it facilitates the measurement of these emotional responses over various sessions and examines their connection with both the individual session and the overall treatment outcomes. The utility of the SPARQ could potentially extend beyond mere routine monitoring, becoming instrumental in transference work (86). This involves exploring how patients engage with their therapists, thereby improving the therapist’s understanding of the types and intensities of emotional reactions encountered. The dimensions identified in the SPARQ likely represent a composite of the intrinsic interpersonal dynamics of the patient, which is evoked in part by the therapist and the therapeutic environment, as well as the dynamics arising from the interactive attitudes and behaviors of both the patient and the therapist during sessions.

The SPARQ showed very good reliability and excellent model fit indices. The average inter-item correlation for the Positive Affect scale was.60, indicating a strong correlation among items. However, in this specific case, i.e., a scale with a very narrow focus, the elevated inter-item correlation results from the assessment of different but closely interrelated facets of the construct being assessed.

Importantly, our findings reveal that the SPARQ maintains measurement invariance whether applied in in-person or remote psychotherapeutic settings. This indicates that SPARQ is an effective tool to uniformly assess patients’ affective reactions in both telepsychotherapy and conventional face-to-face psychotherapy. The significance of this result is enhanced by the rapid shift of teletherapy from a complementary option to becoming a mainstream treatment method in recent years (94), a transition that has been markedly accelerated by the COVID-19 pandemic (95, 96).

Evidence of convergence validity was provided by, on the one hand, very weak correlations of the SPARQ scales with patient demographic, clinical, and treatment variables, as well as weak correlations with traits and state measures, and, on the other hand, moderate to strong correlations with validated measures of specific elements of the therapeutic relationship and a measure of session outcome. All findings of the differential pattern of correlations support the assumption that the affects assessed by our scales are specific to the therapy session and appear to be influenced to a small to moderate degree by the patient’s general psychopathology or extra-therapeutic factors.

However, we found that the negative affective pattern was not completely arbitrary but tended to relate to both the presence of a cluster B personality disorder and the severity of personality pathology. This trend is clinically meaningful and predictable based on the existing literature. In fact, previous studies showed that personality disorders are related to the negative dimensions of the therapeutic relationship (43, 97, 98). These results suggest that therapists treating a patient with a personality disorder, notably cluster B personality disorders, can expect the occurrence of negative attitudes and behavior. By being aware of this situation, the therapist may be able to provide a prompt and effective therapeutic intervention that, among other things, can help reduce premature discontinuation [which is a particularly high risk in patients with a personality disorder (99)].

As expected, the Positive Affect was positively correlated with the measures of working alliance, alliance ruptures and reparations (more specifically, the extent to which the rupture was addressed and resolved in the session), real relationship, and session outcome. Predictability, it was more strongly correlated with the bond component of the WAI-SR than with the other two components. Regarding the Negative Affect, as expected, it was negatively and moderately correlated with the measures of working alliance, real relationship, and session outcome, and positively though weakly correlated with the occurrence of alliance ruptures.

Regarding the relationship between alliance and patient affective reactions toward their therapist, evidence shows that affective reactions predict a substantial part of alliance throughout the course of psychotherapeutic treatment (44). On a clinical level, these findings suggest that by paying adequate attention early in treatment to patterns of affective reactions, therapists can become aware of the potential risks to the alliance relevant to a specific patient, and learn more about the potential benefits of its formation. Ruptures in the alliance, which predict worse treatment outcomes when remaining unrepaired (47), may originate from conflictual emotional processes that emerge in the in-session relational patterns of patients (44, 100). A careful exploration of patterns of affective reactions toward the therapist and alliance ruptures may place the therapist in the best position to manage the alliance by promptly using interventions aimed at disproving negative interpersonal expectations. Empathically tuned interpretation of their in-session affective reactions toward the therapist may be particularly useful in improving patients’ affective awareness and insight into the maladaptive emotional and interpersonal patterns (101, 102) and in jointly exploring in-session interactions (103, 104).

Concerning the session outcome, it is important to note that studies on the relationship between affective reactions toward the therapist and session/treatment outcome have produced contradictory results. As regards negative affective reactions, most of the studies found that the amount of negative transference is negatively related to session outcome (105, 106) and symptom change (107). However, another study found no associations (108). Regarding positive affective reactions, although one study found a positive relationship between positive transference and outcome (106), numerous other studies found no associations (105, 107, 109). These inconsistencies can be partially explained by Gelso and Carter’s (110) theorization that gain in patient insight moderates the effect of transference on the outcome, especially about insight with regard to their negative responses. Two studies offer empirical support, indicating that when patient insight is high, negative reactions relates positively to session and treatment outcomes, whereas in combined with low levels of insight, negative transference harms treatment (108, 111). Furthermore, a meta-analysis on the association between insight and outcome of psychotherapy found a significant moderate relationship (r = .31) (112).

The above allows us to believe that (a) the SPARQ is a clean measure of the in-session therapeutic relationship, (b) the construct measured by the Positive Affect scale is similar, but not isomorphic, to that of the bond alliance, (c) the construct measured by the Negative Affect scale is different with respect to that of the working alliance. Furthermore, our results prompt us to consider whether the positive affect experienced by the patient toward the therapist can foster the working alliance, especially the bond part of it. We also hypothesize that the Positive Affect can act as a buffer against the negative consequences of the (co)presence of the Negative Affect on the strength of the therapeutic relationship.

4.1 Limitations

The findings from this study need to be interpreted in light of some limitations. First, our data are based exclusively on the patient’s perspective. Although patients’ perceptions are fundamental within the psychotherapeutic treatment, they present only one element of a complex dynamic system. This limitation includes the potential bias in self-reporting one’s own affective reactions versus recording respondent’s physiological responses (81), which can capture aspects of emotional reactions that are beyond respondents’ consciousness. However, self-report measures contribute important information on patients’ perceptions and internal experiences of their therapist during a session. Assessing and considering the conscious emotional experience of the patient is clinically crucial when choosing the most appropriate therapeutic intervention. Second, our study lacks measurements of patients’ awareness of mental states in themselves (i.e., mentalization) and capacity to identify and verbalize emotional states (i.e., alexithymia), as well as suppressive emotion regulation strategies, which may be important for collecting valid and reliable data on in-session emotional reactions. This limitation is strictly related to the first one, because here too is there the opportunity for integrating self-rated questionnaires with observer-rated methods (113, 114). A third limitation is that no information on what type of psychotherapy participants were receiving has been collected.

4.2 Future directions

Future research using the SPARQ should examine the affective states and processes assessed from multiple perspectives to further test their validity, assess the correlates, and understand how the scores relate to the therapist’s perceptions of these phenomena, as well as the therapist’s own affective reactions toward the patient. Longitudinal research is required to investigate how these phenomena unfold over the course of psychotherapy and predict different trajectories and outcomes. Lastly, research is needed to evaluate whether the SPARQ can serve as an efficient tool for routine monitoring and systematic client feedback. Currently, it is being tested in a randomized controlled trial to determine whether its use as part of a brief postsession battery can improve the self-monitoring and reflection of patients about their emotional reactions towards their psychotherapists (115), with the ultimate goal of determining if such self-monitoring and reflection can lead to improvements in the quality of the therapeutic relationship, specifically in terms of the working alliance and the real relationship, and to improve treatment outcomes.

5 Conclusion

Our findings support the use of the SPARQ in both clinical and research settings, with particular value for assessing the patient’s subjective affective reactions towards their therapist and session-level affective processes.

Data availability statement

Following the publication of all the research findings, the data will be publicly shared through the Open Science Framework (https://osf.io/amzqk/), further inquiries can be directed to the corresponding author/s.

Ethics statement

The studies involving humans were approved by Institutional Review Board (IRB) of the University of North Carolina at Chapel Hill (Study #: 23-0216; Approval Date: 3/06/2023). The studies were conducted in accordance with the local legislation and institutional requirements. The participants provided their written informed consent to participate in this study.

Author contributions

AS: Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing. PF-P: Supervision, Writing – review & editing. EV: Funding acquisition, Supervision, Writing – review & editing. EY: Conceptualization, Funding acquisition, Methodology, Resources, Supervision, Writing – review & editing.

Funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. The study has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 101030608.

Conflict of interest

EY has received royalties from the American Psychological Association and Guilford Press, and consulted about psychological assessment with Signant Health. He is the co-founder and Executive Director of Helping Give Away Psychological Science HGAPS.org. EV has received grants and served as consultant, advisor or CME speaker for the following entities: AB-Biotics, AbbVie, Adamed, Angelini, Biogen, Boehringer-Ingelheim, Celon Pharma, Compass, Dainippon Sumitomo Pharma, Ethypharm, Ferrer, Gedeon Richter, GH Research, Glaxo-Smith Kline, Janssen, Lundbeck, Medincell, Merck, Novartis, Orion Corporation, Organon, Otsuka, Roche, Rovi, Sage, Sanofi-Aventis, Sunovion, Takeda, and Viatris, outside the submitted work.

The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Supplementary material

The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1346760/full#supplementary-material

References

1. Ekman P. Basic emotions. In: Dalgleish T, Power MJ, editors. Handbook of Cognition and Emotion. John Wiley & Sons, Ltd, Chichester, UK (2005). p. 45–60. doi: 10.1002/0470013494.ch3

CrossRef Full Text | Google Scholar

2. Keltner D, Sauter D, Tracy J, Cowen A. Emotional expression: advances in basic emotion theory. J Nonverbal Behav. (2019) 43:133–60. doi: 10.1007/s10919-019-00293-3

PubMed Abstract | CrossRef Full Text | Google Scholar

3. Ellenberger HF. The discovery of the unconscious: the history and evolution of dynamic psychiatry. New York: Basic Books (2006). [Repr.].

Google Scholar

4. Stefana A. History of Countertransference: From Freud to the British Object Relations School. 1st ed. Routledge (2017). doi: 10.4324/9781315445601

CrossRef Full Text | Google Scholar

5. Stefana A. The origins of the notion of countertransference. Psychoanalytic Rev. (2015) 102:437–60. doi: 10.1521/prev.2015.102.4.437

CrossRef Full Text | Google Scholar

6. Stefana A, Hinshelwood RD, Borensztejn CL. Racker and Heimann on countertransference: Similarities and differences. Psychoanalytic Q. (2021) 90:105–37. doi: 10.1080/00332828.2021.1851136

CrossRef Full Text | Google Scholar

7. Bott Spillius E, Milton J, Garvey P, Couve C, Steiner D. The New Dictionary of Kleinian Thought. Routledge (2011). doi: 10.4324/9780203815762

CrossRef Full Text | Google Scholar

8. Westen D, Gabbard G. Developments in cognitive neuroscience: II. Implications for theories of transference. J Am Psychoanalytic Assoc. (2002) 50:99–134. doi: 10.1177/00030651020500011601

CrossRef Full Text | Google Scholar

9. Yeomans FE, Clarkin LF, Kernberg OF. Transference-focused psychotherapy for borderline personality disorder: A clinical guide. American Psychiatric Publishing (2015).

Google Scholar

10. Stefana A, Langfus JA, Vieta E, Fusar-Poli P, Youngstrom EA. Development and initial validation of the in-Session Patient Affective Reactions Questionnaire (SPARQ) and the rift in-session questionnaire (RISQ). JCM. (2023) 12:5156. doi: 10.3390/jcm12155156

PubMed Abstract | CrossRef Full Text | Google Scholar

11. Beck JS. Cognitive Behavior Therapy, Third Edition: Basics and Beyond. Guilford Publications (2020). 434 p.

Google Scholar

12. Gluhoski VL. Misconceptions of cognitive therapy. Psychother: Theory Res Practice Training. (1994) 31:594–600. doi: 10.1037/0033-3204.31.4.594

CrossRef Full Text | Google Scholar

13. Prasko J, Diveky T, Grambal A, Kamaradova D, Mozny P, Sigmundova Z, et al. Transference and countertransference in cognitive behavioral therapy. Biomed Pap Med Faculty Univ Palacky Olomouc CzechoSlovakia. (2010) 154:189–97. doi: 10.5507/bp.2010.029

CrossRef Full Text | Google Scholar

14. Beck AT. Cognitive Therapy and the Emotional Disorders. Penguin (1979). 409 p.

Google Scholar

15. Gelso CJ, Bhatia A. Crossing theoretical lines: The role and effect of transference in nonanalytic psychotherapies. Psychotherapy. (2012) 49:384–90. doi: 10.1037/a0028802

PubMed Abstract | CrossRef Full Text | Google Scholar

16. Rogers CR. Client-centered therapy: its current practice, implications, and theory. Boston: Houghton Mifflin Co (1951). p. 560.

Google Scholar

17. Perls FS. Gestalt Therapy Verbatim. Real People Press (1969). p. 296.

Google Scholar

18. May R. The Discovery of Being: Writings in Existential Psychology. Norton (1983). p. 192.

Google Scholar

19. Beck AT, Rush AJ. Cognitive therapy of depression. New York: Guilford Press (1979). 425 p.

Google Scholar

20. Goldfried MR, Davison GC. Clinical Behavior Therapy. Holt Rinehart and Winston (1976). 328 p.

Google Scholar

21. Rabinovich M, Kacen L. Let’s look at the elephant: Metasynthesis of transference case studies for psychodynamic and cognitive psychotherapy integration. Psychol Psychother. (2009) 82:427–47. doi: 10.1348/147608309X459662

PubMed Abstract | CrossRef Full Text | Google Scholar

22. Shapiro F. Eye Movement Desensitization and Reprocessing (EMDR) Therapy: Basic Principles, Protocols, and Procedures. Guilford Publications (2017). p. 594.

Google Scholar

23. Hayes JA, Gelso CJ, Goldberg S, Kivlighan DM. Countertransference management and effective psychotherapy: Meta-analytic findings. Psychotherapy. (2018) 55:496–507. doi: 10.1037/pst0000189

PubMed Abstract | CrossRef Full Text | Google Scholar

24. Peluso PR, Freund RR. Therapist and client emotional expression and psychotherapy outcomes: A meta-analysis. Psychotherapy. (2018) 55:461–72. doi: 10.1037/pst0000165

PubMed Abstract | CrossRef Full Text | Google Scholar

25. Sønderland NM, Solbakken OA, Eilertsen DE, Nordmo M, Monsen JT. Emotional changes and outcomes in psychotherapy: A systematic review and meta-analysis. J Consulting Clin Psychol. (2023). doi: 10.1037/ccp0000814

CrossRef Full Text | Google Scholar

26. Faustino B. Minding my brain: Fourteen neuroscience-based principles to enhance psychotherapy responsiveness. Clin Psychol Psychoth. (2022) 29:1254–75. doi: 10.1002/cpp.2719

CrossRef Full Text | Google Scholar

27. Lane RD, Subic-Wrana C, Greenberg L, Yovel I. The role of enhanced emotional awareness in promoting change across psychotherapy modalities. J Psychother Integration. (2022) 32:131–50. doi: 10.1037/int0000244

CrossRef Full Text | Google Scholar

28. Greenberg LS. The clinical application of emotion in psychotherapy. In: Lewis M, Haviland-Jones JM, Barrett LF, editors. Handbook of emotions. Guilford Press (2008). p. 88–101.

Google Scholar

29. Greenberg LS. Emotions, the great captains of our lives: Their role in the process of change in psychotherapy. Am Psychol. (2012) 67:697–707. doi: 10.1037/a0029858

PubMed Abstract | CrossRef Full Text | Google Scholar

30. Greenberg LS, Goldman RN. Theory of practice of emotion-focused therapy. In: Greenberg LS, Goldman RN, editors. Clinical handbook of emotion-focused therapy. American Psychological Association, Washington (2019). p. 61–89. doi: 10.1037/0000112-003

CrossRef Full Text | Google Scholar

31. Greenberg LS. Theory of functioning in emotion-focused therapy. In: Greenberg LS, Goldman RN, editors. Clinical handbook of emotion-focused therapy. American Psychological Association, Washington (2019). p. 37–59. doi: 10.1037/0000112-002

CrossRef Full Text | Google Scholar

32. Lane RD, Ryan L, Nadel L, Greenberg L. Memory reconsolidation, emotional arousal, and the process of change in psychotherapy: New insights from brain science. Behav Brain Sci. (2015) 38:e1. doi: 10.1017/S0140525X14000041

PubMed Abstract | CrossRef Full Text | Google Scholar

33. Høglend P. Exploration of the patient-therapist relationship in psychotherapy. AJP. (2014) 171:1056–66. doi: 10.1176/appi.ajp.2014.14010121

CrossRef Full Text | Google Scholar

34. Subic-Wrana C, Greenberg LS, Lane RD, Michal M, Wiltink J, Beutel ME. Affective change in psychodynamic psychotherapy: theoretical models and clinical approaches to changing emotions. Z für Psychosomatische Med und Psychotherapie. (2016) 62:207–23. doi: 10.13109/zptm.2016.62.3.207

CrossRef Full Text | Google Scholar

35. Hayes JA, Vinca M. Therapist presence, absence, and extraordinary presence. In: Castonguay LG, Hill CE, editors. How and why are some therapists better than others?: Understanding therapist effects. American Psychological Association, Washington (2017). p. 85–99. doi: 10.1037/0000034-006

CrossRef Full Text | Google Scholar

36. Izard CE, Porges SW, Simons RF, Haynes OM, Hyde C, Parisi M, et al. Infant cardiac activity: Developmental changes and relations with attachment. Dev Psychol. (1991) 27:432–9. doi: 10.1037/0012-1649.27.3.432

CrossRef Full Text | Google Scholar

37. Watson D, Clark LA, Tellegen A. Development and validation of brief measures of positive and negative affect: The PANAS scales. J Pers Soc Psychol. (1988) 54:1063–70. doi: 10.1037/0022-3514.54.6.1063

PubMed Abstract | CrossRef Full Text | Google Scholar

38. Norcross JC, Guadagnoli E, Prochaska JO. Factor structure of the Profile of Mood States (POMS): two partial replications. J Clin Psychol. (1984) 40:1270–7. doi: 10.1002/1097-4679(198409)40:5<1270::aid-jclp2270400526>3.0.co;2-7

PubMed Abstract | CrossRef Full Text | Google Scholar

39. McNair N, Lorr M, Droppleman L. Profile of mood states manual (rev.). (1992). San Diego, CA, USA: Education and Industrial Testing Service

Google Scholar

40. Norcross JC, Lambert MJ. Psychotherapy relationships that work (3rd ed). Volume 1: Evidence-based therapist contributions. New York: Oxford University Press (2019).

Google Scholar

41. Graff H, Luborsky L. Long-term trends in transference and resistance: A report on A quantitative-analytic method applied to four psychoanalyses. J Am Psychoanalytic Assoc. (1977) 25:471–90. doi: 10.1177/000306517702500210

CrossRef Full Text | Google Scholar

42. Multon KD, Patton MJ, Kivlighan DM. Development of the missouri identifying transference scale. J Couns Psychol. (1996) 43:243–52. doi: 10.1037/0022-0167.43.3.243

CrossRef Full Text | Google Scholar

43. Bradley R, Heim AK, Westen D. Transference patterns in the psychotherapy of personality disorders: empirical investigation. Br J Psychiatry. (2005) 186:342–9. doi: 10.1192/bjp.186.4.342

PubMed Abstract | CrossRef Full Text | Google Scholar

44. Zilcha-Mano S, McCarthy KS, Dinger U, Barber JP. To what extent is alliance affected by transference? An empirical exploration. Psychother (Chic). (2014) 51:424–33. doi: 10.1037/a0036566

CrossRef Full Text | Google Scholar

45. Wampold BE, Flückiger C. The alliance in mental health care: conceptualization, evidence and clinical applications. World Psychiatry. (2023) 22:25–41. doi: 10.1002/wps.21035

PubMed Abstract | CrossRef Full Text | Google Scholar

46. Flückiger C, Del Re AC, Wampold BE, Horvath AO. The alliance in adult psychotherapy: A meta-analytic synthesis. Psychotherapy. (2018) 55:316–40. doi: 10.1037/pst0000172

PubMed Abstract | CrossRef Full Text | Google Scholar

47. McLaughlin AA, Keller SM, Feeny NC, Youngstrom EA, Zoellner LA. Patterns of therapeutic alliance: Rupture–repair episodes in prolonged exposure for posttraumatic stress disorder. J Consulting Clin Psychol. (2014) 82:112–21. doi: 10.1037/a0034696

CrossRef Full Text | Google Scholar

48. Dillman DA, Smyth JD, Christian LM. Internet, phone, mail, and mixed mode surveys: The tailored design method. 4th ed. Hoboken, NJ, US: John Wiley & Sons Inc (2014). 509 p.

Google Scholar

49. Streiner DL, Norman GR, Cairney J. Health measurement scales: A practical guide to their development and use. Fifth Edition. Oxford, New York: Oxford University Press (2015). 399 p.

Google Scholar

50. Freeman AJ, Young J. Assessing process: Are we there yet? In: Youngstrom EA, Prinstein MJ, Mash EJ, Barkley R, editors. Assessment of Disorders in Childhood and Adolescence. Guilford Press, New York, NY (2020). p. 75–90.

Google Scholar

51. Youngstrom EA, Prinstein MJ. Introduction to evidence-based assessment: A recipe for success. In: Youngstrom EA, Prinstein MJ, Mash EJ, Barkley R, editors. Assessment of Disorders in Childhood and Adolescence. Guilford Press, New York, NY (2020). p. 3–29.

Google Scholar

52. Stefana A, Fusar-Poli P, Vieta E, Gelso CJ, Youngstrom EA. Development and validation of an 8-item version of the Real Relationship Inventory–Client form. Psychother Res. (2024) 1–17. doi: 10.1080/10503307.2024.2320331

PubMed Abstract | CrossRef Full Text | Google Scholar

53. Stefana A, Bulgari V, Youngstrom EA, Dakanalis A, Bordin C, Hopwood CJ. Patient personality and psychotherapist reactions in individual psychotherapy setting: a systematic review. Clin Psychol Psychoth. (2020) 27:697–713. doi: 10.1002/cpp.2455

CrossRef Full Text | Google Scholar

54. Brown TA. Confirmatory factor analysis for applied research. New York, NY, US: The Guilford Press (2006). 475 p.

Google Scholar

55. Guion RM. Assessment, Measurement, and Prediction for Personnel Decisions. 2nd ed. New York: Routledge (2011). 648 p. doi: 10.4324/9780203836767

CrossRef Full Text | Google Scholar

56. DeVellis RF, Thorpe CT. Scale development: theory and applications. Fifth edition. Thousand Oaks, California: SAGE Publications, Inc (2022). 298 p.

Google Scholar

57. Streiner DL, Norman GR, Cairney J. Health measurement scales: A practical guide to their development and use. 5th ed. New York, NY, US: Oxford University Press (2015). 399 p. doi: 10.1093/med/9780199685219.001.0001

CrossRef Full Text | Google Scholar

58. Dillman DA, Smyth JD, Christian LM. Internet, Phone, Mail, and Mixed-Mode Surveys: The Tailored Design Method. John Wiley & Sons (2014). 532 p.

Google Scholar

59. Soto CJ, John OP. Short and extra-short forms of the Big Five Inventory–2: The BFI-2-S and BFI-2-XS. J Res Pers. (2017) 68:69–81. doi: 10.1016/j.jrp.2017.02.004

CrossRef Full Text | Google Scholar

60. Weekers LC, Hutsebaut J, Kamphuis JH. The Level of Personality Functioning Scale-Brief Form 2.0: Update of a brief instrument for assessing level of personality functioning: The Level of Personality Functioning Scale - Brief Form 2.0. Pers Ment Health. (2019) 13:3–14. doi: 10.1002/pmh.1434

CrossRef Full Text | Google Scholar

61. Thompson ER. Development and validation of an internationally reliable short-form of the positive and negative affect schedule (PANAS). J Cross-Cultural Psychol. (2007) 38:227–42. doi: 10.1177/0022022106297301

CrossRef Full Text | Google Scholar

62. Kroenke K, Spitzer RL, Williams JBW. The PHQ-9: Validity of a brief depression severity measure. J Gen Intern Med. (2001) 16:606–13. doi: 10.1046/j.1525-1497.2001.016009606.x

PubMed Abstract | CrossRef Full Text | Google Scholar

63. Beard C, Hsu KJ, Rifkin LS, Busch AB, Björgvinsson T. Validation of the PHQ-9 in a psychiatric sample. J Affect Disord. (2016) 193:267–73. doi: 10.1016/j.jad.2015.12.075

PubMed Abstract | CrossRef Full Text | Google Scholar

64. Spitzer RL, Kroenke K, Williams JBW, Löwe B. A brief measure for assessing generalized anxiety disorder: the GAD-7. Arch Intern Med. (2006) 166:1092–7. doi: 10.1001/archinte.166.10.1092

PubMed Abstract | CrossRef Full Text | Google Scholar

65. Zimmerman M, Ruggero CJ, Chelminski I, Young D, Posternak MA, Friedman M, et al. Developing brief scales for use in clinical practice: the reliability and validity of single-item self-report measures of depression symptom severity, psychosocial impairment due to depression, and quality of life. J Clin Psychiatry. (2006) 67:1536–41. doi: 10.4088/JCP.v67n1007

PubMed Abstract | CrossRef Full Text | Google Scholar

66. Hatcher RL, Gillaspy JA. Development and validation of a revised short version of the working alliance inventory. Psychother Res. (2006) 16:12–25. doi: 10.1080/10503300500352500

CrossRef Full Text | Google Scholar

67. Kelley FA, Gelso CJ, Fuertes JN, Marmarosh C, Lanier SH. The Real Relationship Inventory: Development and psychometric investigation of the client form. Psychother: Theory Res Practice Training. (2010) 47:540–53. doi: 10.1037/a0022082

CrossRef Full Text | Google Scholar

68. Gelso CJ. The real relationship in a postmodern world: Theoretical and empirical explorations. Psychother Res. (2009) 19:253–64. doi: 10.1080/10503300802389242

PubMed Abstract | CrossRef Full Text | Google Scholar

69. Samstag LW, Batchelder ST, Muran JC, Safran JD, Winston A. Early identification of treatment failures in short-term psychotherapy. An assessment of therapeutic alliance and interpersonal behavior. J Psychother Pract Res. (1998) 7:126–43.

PubMed Abstract | Google Scholar

70. Lent RW, Hoffman MA, Hill CE, Treistman D, Mount M, Singley D. Client-specific counselor self-efficacy in novice counselors: Relation to perceptions of session quality. J Couns Psychol. (2006) 53:453–63. doi: 10.1037/0022-0167.53.4.453

CrossRef Full Text | Google Scholar

71. Hill CE, Kellems IS. Development and use of the helping skills measure to assess client perceptions of the effects of training and of helping skills in sessions. J Couns Psychol. (2002) 49:264–72. doi: 10.1037/0022-0167.49.2.264

CrossRef Full Text | Google Scholar

72. Rosseel Y. lavaan: an R package for structural equation modeling. J Stat Soft. (2012) 48. doi: 10.18637/jss.v048.i02

CrossRef Full Text | Google Scholar

73. Hu L, Bentler PM. Cutoff criteria for fit indexes in covariance structure analysis: Conventional criteria versus new alternatives. Struct Equation Modeling. (1999) 6:1–55. doi: 10.1080/10705519909540118

CrossRef Full Text | Google Scholar

74. Kline RB. Principles and Practice of Structural Equation Modeling. Guilford Publications (2023). 514 p.

Google Scholar

75. Chalmers RP. mirt: A multidimensional item response theory package for the R environment. J Stat Soft. (2012) 48. doi: 10.18637/jss.v048.i06

CrossRef Full Text | Google Scholar

76. Revelle W. psych: Procedures for Psychological, Psychometric, and Personality Research. Evanston, Illinois: Northwestern University (2022). Available at: https://CRAN.R-project.org/package=psych. R package version 2.2.5.

Google Scholar

77. Revelle W, Condon DM. Reliability from α to ω: A tutorial. psychol Assess. (2019) 31:1395–411. doi: 10.1037/pas0000754

PubMed Abstract | CrossRef Full Text | Google Scholar

78. Baker FB, Kim S-H. The Basics of Item Response Theory Using R. Cham: Springer International Publishing (2017). doi: 10.1007/978-3-319-54205-8

CrossRef Full Text | Google Scholar

79. Wise EA. Statistical significance testing and clinical effectiveness studies. Psychotherapy. (2011) 48:225–8. doi: 10.1037/a0022701

PubMed Abstract | CrossRef Full Text | Google Scholar

80. Swinscow TDV, Campbell MJ. Statistics at square one. 10. ed. London: BMJ Publ. Group (2004). 158 p. 3rd impr., repr.

Google Scholar

81. Ciuk D, Troy AK, Jones MC. Measuring emotion: self-reports vs. physiological indicators. SSRN J. (2015) 44(3):300–15. doi: 10.2139/ssrn.2595359

CrossRef Full Text | Google Scholar

82. Markin RD, Kivlighan DM. Bias in psychotherapist ratings of client transference and insight. Psychother: Theory Res Practice Training. (2007) 44:300–15. doi: 10.1037/0033-3204.44.3.300

CrossRef Full Text | Google Scholar

83. Benecke C, Peham D, Bänninger-Huber E. Nonverbal relationship regulation in psychotherapy. Psychother Res. (2005) 15:81–90. doi: 10.1080/10503300512331327065

CrossRef Full Text | Google Scholar

84. Wieder G, Fischer MS, Einsle F, Baucom DH, Hahlweg K, Wittchen H-U, et al. Fundamental frequency during cognitive preparation and its impact on therapy outcome for panic disorder with Agoraphobia. Behav Res Ther. (2020) 135:103728. doi: 10.1016/j.brat.2020.103728

PubMed Abstract | CrossRef Full Text | Google Scholar

85. Carlier IVE, Meuldijk D, Van Vliet IM, Van Fenema E, van der Wee NJA, Zitman FG. Routine outcome monitoring and feedback on physical or mental health status: evidence and theory: Feedback on physical or mental health status. J Eval Clin Pract. (2012) 18:104–10. doi: 10.1111/j.1365-2753.2010.01543.x

PubMed Abstract | CrossRef Full Text | Google Scholar

86. Høglend P, Gabbard GO. When is transference work useful in psychodynamic psychotherapy? A review of empirical research. In: Levy RA, Ablon JS, Kächele H, editors. Psychodynamic Psychotherapy Research. Humana Press, Totowa, NJ (2012). p. 449–67. doi: 10.1007/978-1-60761-792-1_26

CrossRef Full Text | Google Scholar

87. Lambert MJ, Whipple JL, Kleinstäuber M. Collecting and delivering progress feedback: A meta-analysis of routine outcome monitoring. Psychotherapy. (2018) 55:520–37. doi: 10.1037/pst0000167

PubMed Abstract | CrossRef Full Text | Google Scholar

88. Poston JM, Hanson WE. Meta-analysis of psychological assessment as a therapeutic intervention. psychol Assess. (2010) 22:203–12. doi: 10.1037/a0018679

PubMed Abstract | CrossRef Full Text | Google Scholar

89. Bickman L. A measurement feedback system (MFS) is necessary to improve mental health outcomes. J Am Acad Child Adolesc Psychiatry. (2008) 47:1114–9. doi: 10.1097/CHI.0b013e3181825af8

PubMed Abstract | CrossRef Full Text | Google Scholar

90. Colli A, Tanzilli A, Gualco I, Lingiardi V. Empirically derived relational pattern prototypes in the treatment of personality disorders. Psychopathology. (2016) 49:364–73. doi: 10.1159/000448623

PubMed Abstract | CrossRef Full Text | Google Scholar

91. Gabbard GO. Psychodynamic psychiatry in clinical practice. 5th ed. Arlington, VA: American Psychiatric Publishing (2014).

Google Scholar

92. McWilliams N. Psychoanalytic diagnosis: Understanding personality structure in the clinical process (2nd ed.). Guilford Press (2011).

Google Scholar

93. Prasko J, Ociskova M, Vanek J, Burkauskas J, Slepecky M, Bite I, et al. Managing transference and countertransference in cognitive behavioral supervision: theoretical framework and clinical application. PRBM. (2022) 15:2129–55. doi: 10.2147/PRBM.S369294

CrossRef Full Text | Google Scholar

94. Pierce BS, Perrin PB, McDonald SD. Demographic, organizational, and clinical practice predictors of U.S. psychologists’ use of telepsychology. Prof Psychol: Res Pract. (2020) 51:184–93. doi: 10.1037/pro0000267

CrossRef Full Text | Google Scholar

95. Stefana A, Youngstrom EA, Hopwood CJ, Dakanalis A. The COVID-19 pandemic brings a second wave of social isolation and disrupted services. Eur Arch Psychiatry Clin Neurosci. (2020) 270:785–6. doi: 10.1007/s00406-020-01137-8

PubMed Abstract | CrossRef Full Text | Google Scholar

96. Zangani C, Ostinelli EG, Smith KA, Hong JSW, Macdonald O, Reen G, et al. Impact of the COVID-19 pandemic on the global delivery of mental health services and telemental health: systematic review. JMIR Ment Health. (2022) 9:e38600. doi: 10.2196/38600

PubMed Abstract | CrossRef Full Text | Google Scholar

97. Clarkin JF, Yeomans FE, Kernberg OF. Psychotherapy for borderline personality. Wiley (1999).

Google Scholar

98. Tanzilli A, Colli A, Gualco I, Lingiardi V. Patient personality and relational patterns in psychotherapy: Factor structure, reliability, and validity of the psychotherapy relationship questionnaire. J Pers Assess. (2018) 100:96–106. doi: 10.1080/00223891.2016.1272050

PubMed Abstract | CrossRef Full Text | Google Scholar

99. Swift JK, Greenberg RP. Premature discontinuation in adult psychotherapy: A meta-analysis. J Consulting Clin Psychol. (2012) 80:547–59. doi: 10.1037/a0028226

CrossRef Full Text | Google Scholar

100. Safran JD, Muran JC, Eubanks-Carter C. Repairing alliance ruptures. Psychotherapy. (2011) 48:80–7. doi: 10.1037/a0022140

PubMed Abstract | CrossRef Full Text | Google Scholar

101. Høglend P, Hagtvet K. Change mechanisms in psychotherapy: Both improved insight and improved affective awareness are necessary. J Consulting Clin Psychol. (2019) 87:332–44. doi: 10.1037/ccp0000381

CrossRef Full Text | Google Scholar

102. Levy KN, Scala JW. Transference, transference interpretations, and transference-focused psychotherapies. Psychotherapy. (2012) 49:391–403. doi: 10.1037/a0029371

PubMed Abstract | CrossRef Full Text | Google Scholar

103. DeFife JA, Hilsenroth MJ, Kuutmann K. Beyond transference: Fostering growth through therapeutic immediacy. In: Handbook of psychodynamic approaches to psychopathology. The Guilford Press, New York, NY, US (2015). p. 512–28.

Google Scholar

104. Kuutmann K, Hilsenroth MJ. Exploring in-session focus on the patient–therapist relationship: patient characteristics, process and outcome. Clin Psychol Psychoth. (2012) 19:187–202. doi: 10.1002/cpp.743

CrossRef Full Text | Google Scholar

105. Bhatia A, Gelso CJ. Therapists’ perspective on the therapeutic relationship: Examining a tripartite model. Counselling Psychol Q. (2018) 31:271–93. doi: 10.1080/09515070.2017.1302409

CrossRef Full Text | Google Scholar

106. Markin RD, McCarthy KS, Barber JP. Transference, countertransference, emotional expression, and session quality over the course of supportive expressive therapy: The raters’ perspective. Psychother Res. (2013) 23:152–68. doi: 10.1080/10503307.2012.747013

PubMed Abstract | CrossRef Full Text | Google Scholar

107. Marmarosh CL, Gelso CJ, Markin RD, Majors R, Mallery C, Choi J. The real relationship in psychotherapy: Relationships to adult attachments, working alliance, transference, and therapy outcome. J Couns Psychol. (2009) 56:337–50. doi: 10.1037/a0015169

CrossRef Full Text | Google Scholar

108. Gelso CJ, Kivlighan DM, Wine B, Jones A, Friedman SC. Transference, insight, and the course of time-limited therapy. J Couns Psychol. (1997) 44:209–17. doi: 10.1037/0022-0167.44.2.209

CrossRef Full Text | Google Scholar

109. Gelso CJ, Kelley FA, Fuertes JN, Marmarosh C, Holmes SE, Costa C, et al. Measuring the real relationship in psychotherapy: initial validation of the therapist form. J Couns Psychol. (2005) 52:640–9. doi: 10.1037/0022-0167.52.4.640

CrossRef Full Text | Google Scholar

110. Gelso CJ, Carter JA. Components of the psychotherapy relationship: Their interaction and unfolding during treatment. J Couns Psychol. (1994) 41:296–306. doi: 10.1037/0022-0167.41.3.296

CrossRef Full Text | Google Scholar

111. Gelso CJ, Hill CE, Kivlighan DM. Transference, insight, and the counselor’s intentions during a counseling hour. J Couns Dev. (1991) 69:428–33. doi: 10.1002/j.1556-6676.1991.tb01539.x

CrossRef Full Text | Google Scholar

112. Jennissen S, Huber J, Ehrenthal JC, Schauenburg H, Dinger U. Association between insight and outcome of psychotherapy: systematic review and meta-analysis. AJP. (2018) 175:961–9. doi: 10.1176/appi.ajp.2018.17080847

CrossRef Full Text | Google Scholar

113. da Silva ACN, Vasco AB, Watson JC. Alexithymia and therapeutic alliance: a multiple case study comparing good and poor outcome cases. Res Psychother. (2018) 21:313. doi: 10.4081/ripppo.2018.313

PubMed Abstract | CrossRef Full Text | Google Scholar

114. Muzi S, Di Trani M, Renzi A, Pace CS. Can alexithymia be assessed through an interview in adolescents? The Toronto Structured Interview for Alexithymia: Reliability, concurrent validity, discriminant validity, and relationships with emotional-behavioral symptoms. Front Psychiatry. (2022) 13:1055946. doi: 10.3389/fpsyt.2022.1055946

PubMed Abstract | CrossRef Full Text | Google Scholar

115. Stefana A, Vieta E, Fusar-Poli P, Youngstrom EA. Enhance psychotherapy outcomes by encouraging patients to regularly self-monitor, reflect on, and share their affective responses toward their therapist: Protocol for a randomized controlled trial. JMIR Res Protoc. (2024) 13:e55369. doi: 10.2196/55369

PubMed Abstract | CrossRef Full Text | Google Scholar

Appendix

in-Session Patient Affective Reactions Questionnaire (SPARQ)

The following is a series of statements that people in psychotherapy might use to describe how they feel toward their psychotherapist. Think about your last psychotherapy session and remember some details from it. Then read each statement and indicate how you felt during that session. Select the response that corresponds with your answer with ‘0’ being not at all and ‘4’ being very much. Do not worry if your responses appear to be inconsistent, as people often experience mixed and conflicting feelings.

Keywords: therapeutic relationship, affective reaction, emotional reaction, in-session process, self-report measure, psychotherapy, psychological assessment, evidence-based assessment

Citation: Stefana A, Fusar-Poli P, Vieta E and Youngstrom EA (2024) Assessing the patient’s affective perception of their psychotherapist: validation of the in-Session Patient Affective Reactions Questionnaire. Front. Psychiatry 15:1346760. doi: 10.3389/fpsyt.2024.1346760

Received: 29 November 2023; Accepted: 08 April 2024;
Published: 24 April 2024.

Edited by:

Daniela Marchetti, University of Studies G. d’Annunzio Chieti and Pescara, Italy

Reviewed by:

Cecilia Serena Pace, University of Genoa, Italy
Virpi-Liisa Kykyri, University of Jyväskylä, Finland

Copyright © 2024 Stefana, Fusar-Poli, Vieta and Youngstrom. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence: Alberto Stefana, alberto.stefana@gmail.com

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