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Original Research ARTICLE Provisionally accepted The full-text will be published soon. Notify me

Front. Vet. Sci. | doi: 10.3389/fvets.2019.00243

Pilot Study Assessing Treatment of Canine Hip Dysplasia using Autologous Protein Solution

  • 1Colorado Canine Orthopedics and Rehab, United States

Five dogs with bilateral hip dysplasia and without osteoarthritis of other joints were enrolled in this pilot study. Objective kinetic data using a pressure sensitive mat and owner assessments using the canine brief pain inventory (CBPI) and Liverpool Osteoarthritis for Dogs (LOAD) questionnaires were obtained prior to treatment. Enrolled dogs were treated in one hip with autologous protein solution (APS) and the contralateral hip was injected with an equal volume of saline. The hip to be treated was selected using a random number generator. At exactly 28 days following treatment dogs were re-assessed using the pressure sensitive mat and the CBPI and LOAD questionnaires. No dogs were treated with any other medications or supplements throughout the study period. Assessment of the total pressure index collected using the pressure sensitive mat showed that the hips treated with APS improved significantly more than hips treated with saline (p=0.0005) and that the hips treated with APS bore significantly more weight than the hips treated with saline at day 28 (p < 0.05). Statistically significant improvement was noted by owners in “pain” and “function” as assessed by the CBPI as well “mobility at exercise” using the LOAD questionnaire. This pilot study provided proof of principle that APS is beneficial in treating pain and lameness in dogs affected by coxofemoral osteoarthritis.

Keywords: canine, Hip dysplasia, Osteoarthritis, autologous protein solution, APS

Received: 03 Apr 2019; Accepted: 08 Jul 2019.

Edited by:

Fausto Cremonesi, University of Milan, Italy

Reviewed by:

Francisco Miguel Sanchez Margallo, Centro de Cirugía de Mínima Invasión Jesús Usón, Spain
Wanda J. Gordon-Evans, Independent researcher
Arianna B. Lovati, Istituto Ortopedico Galeazzi (IRCCS), Italy  

Copyright: © 2019 Franklin. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Dr. Samuel P. Franklin, Colorado Canine Orthopedics and Rehab, Colorado Springs, 80918, Colorado, United States,