In the published article, there was an error in Figure 5 as published. In particular, the Western blot showed in the original Figure 5D related to the 1st round of PMCA of patient 19 (19_BH) was mistakenly selected and has now been replaced with the correct one. The corrected Figure 5D and its caption appear below.
Figure 5
Quantitative PMCA (qPMCA) for estimating PrPres concentration in OM samples of sCJD patients. (A) Serial dilutions of recombinant full-length human PrP (recHuPrP23 − 231) were used to estimate prion concentration in the brain of sCJD patients. (B) Serial dilutions of sCJD brain homogenates subjected to PK and PNGase treatments before Wb analysis. Quantitative PMCA to estimate PrPres concentration in OM of (C) MM1, (D) MV2, and (E) VV2 patients. Specific rounds at which every OM PrPres was detected (3rd for the MM1 and one VV2, 5th for one MV2 and one VV2, and 6th for one MV2) are shown.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
Statements
Publisher’s note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Summary
Keywords
Creutzfeldt–Jakob disease, olfactory mucosa, protein misfolding cyclic amplification, neurodegeneration, prion, peripheral biomarker
Citation
Cazzaniga FA, Bistaffa E, De Luca CMG, Portaleone SM, Catania M, Redaelli V, Tramacere I, Bufano G, Rossi M, Caroppo P, Giovagnoli AR, Tiraboschi P, Di Fede G, Eleopra R, Devigili G, Elia AE, Cilia R, Fiorini M, Bongianni M, Salzano G, Celauro L, Quarta FG, Mammana A, Legname G, Tagliavini F, Parchi P, Zanusso G, Giaccone G and Moda F (2023) Corrigendum: PMCA-based detection of prions in the olfactory mucosa of patients with sporadic Creutzfeldt–Jakob disease. Front. Aging Neurosci. 15:1073356. doi: 10.3389/fnagi.2023.1073356
Received
18 October 2022
Accepted
13 February 2023
Published
27 February 2023
Volume
15 - 2023
Edited and reviewed by
Rodrigo Morales, University of Texas Health Science Center at Houston, United States
Updates
Copyright
© 2023 Cazzaniga, Bistaffa, De Luca, Portaleone, Catania, Redaelli, Tramacere, Bufano, Rossi, Caroppo, Giovagnoli, Tiraboschi, Di Fede, Eleopra, Devigili, Elia, Cilia, Fiorini, Bongianni, Salzano, Celauro, Quarta, Mammana, Legname, Tagliavini, Parchi, Zanusso, Giaccone and Moda.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Fabio Moda fabio.moda@istituto-besta.it
†Present addresses: Martina Rossi, Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy
This article was submitted to Alzheimer's Disease and Related Dementias, a section of the journal Frontiers in Aging Neuroscience
Disclaimer
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.