In the published article “Chawla, S., Gulyani, S., Allen, RP., Earley, C.J., Li, X., Van, Zijl. P., et al. (2019). Extracellular vesicles reveal abnormalities in neuronal iron metabolism in restless legs syndrome. Sleep 42, zsz079. 10.1093/sleep/zsz079” was not cited in the article. The citation has now been inserted in introduction, Paragraph 5 and should read:
“Studies of iron and iron-related proteins levels in cerebrospinal fluid (CSF), serum, plasma, and urine have shown conflicting results. Meta-analyses of these studies have revealed that CSF and serum/plasma ferritin and transferrin concentrations did not differ significantly between PD patients and controls (Jimenez-Jimenez et al., 2021). However, recent studies have shown that exosomes were a pathway for neurons to divert proteins from neurons into the CSF or into the peripheral blood via the blood-brain barrier (Shi et al., 2014). Exosomal a-synuclein in neural-derived blood exosomes was found to be increased in patients with PD (Shi et al., 2016). Chalwa's group studied the iron homeostasis in restless legs syndrome, and found that the patients had higher levels of total ferritin and heavy-chain ferritin, and similar levels of TfR in serum neural-derived exosomes (Chawla et al., 2019). To investigate the mechanism of iron deposition and to identify potential novel biomarkers for PD, this study evaluated the levels of ferritin and TfR level in plasma neural-derived exosomes using enzyme-linked immunosorbent assay (ELISA).”
In the published article, there was an error. Chawla's team has made pioneering work on the study of iron metabolism in blood neuro-exosomes, although the patients in their study were RLS, but not PD. There are some of the expressions in our original article are not rigorous enough.
A correction has been made to abstract, introduction. This sentence previously stated:
“While the blood of healthy animals contains a plentiful supply of TfR positive exosomes, no studies have examined ferritin and TfR in plasma neuralderived exosomes.”
The corrected sentence appears below:
“While the blood of healthy animals contains a plentiful supply of TfR positive exosomes, rare study has examined ferritin and TfR in plasma neural-derived exosomes in PD.”
The other correction has been made to introduction, Paragraph 5. This sentence previously stated:
“To investigate the mechanism of iron deposition and to identify potential novel biomarkers for PD, this study evaluated the levels of ferritin and TfR level in plasma neural-derived exosomes using enzyme-linked immunosorbent assay (ELISA).”
The corrected sentence appears below:
“Chalwa's group studied the iron homeostasis in restless legs syndrome, and found that the patients had higher levels of total ferritin and heavy-chain ferritin, and similar levels of TfR in serum neural-derived exosomes (Chawla et al., 2019). To investigate the mechanism of iron deposition and to identify potential novel biomarkers for PD, this study evaluated the levels of ferritin and TfR level in plasma neural-derived exosomes using enzyme-linked immunosorbent assay (ELISA).”
In the published article, there was an error in “Figure 3. Comparation of ferritin and TfR in PD and controls, and ROC analysis of biomarkers for PD diagnosis” as published. In Figure 3A and 3B, “PD” and “control” was reversed by mistake. The corrected “Figure 3. Comparation of ferritin and TfR in PD and controls, and ROC analysis of biomarkers for PD diagnosis” and its caption appear below. In Figure 3A and 3B, “PD” and “control” swapped positions.
Figure 3
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
References
1
ChawlaS.GulyaniS.AllenRP.EarleyC.J.LiX.Van ZijlP.et al. (2019). Extracellular vesicles reveal abnormalities in neuronal iron metabolism in restless legs syndrome. Sleep 42, zsz079. 10.1093/sleep/zsz079
2
Jimenez-JimenezF. J.Alonso-NavarroH.Garcia-MartinE.AgundezJ. A. G. (2021). Biological fluid levels of iron and iron-related proteins in Parkinson's disease: Review and meta-analysis. Eur. J. Neurol.28, 1041–1055. 10.1111/ene.14607
3
ShiM.KovacA.KorffA.CookT. J.GinghinaC.BullockK. M.et al. (2016). CNS tau efflux via exosomes is likely increased in Parkinson's disease but not in Alzheimer's disease. Alzheimers Dement. J. Alzheimers Assoc.12, 1125–1131. 10.1016/j.jalz.2016.04.003
4
ShiM.LiuC.CookT. J.BullockK. M.ZhaoY.GinghinaC.et al. (2014). Plasma exosomal alpha-synuclein is likely CNS-derived and increased in Parkinson's disease. Acta Neuropathol.128, 639–650. 10.1007/s00401-014-1314-y
Summary
Keywords
biomarker, ferritin, transferrin receptor, exosome, Parkinson's disease
Citation
Chen Z, Pan C, Ruan X, Lei L, Lin S, Wang Y and Zhao Z-H (2024) Corrigendum: Evaluation of ferritin and TfR level in plasma neural-derived exosomes as potential markers of Parkinson's disease. Front. Aging Neurosci. 15:1355200. doi: 10.3389/fnagi.2023.1355200
Received
13 December 2023
Accepted
29 December 2023
Published
19 January 2024
Volume
15 - 2023
Edited and reviewed by
Robert Petersen, College of Medicine, Central Michigan University, United States
Updates
Copyright
© 2024 Chen, Pan, Ruan, Lei, Lin, Wang and Zhao.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Yin-zhou Wang wphd@163.comZhen-Hua Zhao 30470353@qq.com
†These authors have contributed equally to this work
Disclaimer
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