CORRECTION article

Front. Aging Neurosci., 04 July 2024

Sec. Cellular and Molecular Mechanisms of Brain-aging

Volume 16 - 2024 | https://doi.org/10.3389/fnagi.2024.1072608

Corrigendum: Glutamatergic and GABAergic neurons in the preoptic area of the hypothalamus play key roles in menopausal hot flashes

  • 1. Department of Human Anatomy, Histology and Embryology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China

  • 2. Department of Stomatology, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, Shanxi, China

  • 3. Department of Stomatology, The Third Medical Center, Chinese PLA General Hospital, Beijing, China

  • 4. Beijing Key Lab of Magnetic Resonance Imaging Technology, Peking University Third Hospital, Beijing, China

In the published article, there was an error in Figure 3 as published. The wrong slide of microscopy was provided for OVX + E group in Figure 3A. There were incorrect kDa values of Vglut2 and Vgat due to clerical errors, and there were red curves below kDa and Vgat caused by spell checking in Figures 3H, K. The corrected Figure 3 and its caption appear below.

Figure 3

In the published article, there was an error in Figure 6 as published. There were red curves below kDa caused by spell checking in Figures 6F, I. The corrected Figure 6 and its caption appear below.

Figure 6

In the published article, there was an error in Figure 9 as published. There were red curves below kDa and Vgat caused by spell checking in Figures 9D, G, and the abbreviation for ERα antagonist, AZD, was misspelled as ZAD due to an error in Figures 9E, H. And there were incorrect kDa values in the caption due to clerical errors. The corrected Figure 9 and its caption appear below.

Figure 9

In the published article, there was an error in Figure 10 as published. There were red curves below kDa and Vgat caused by spell checking in Figures 10D, G, and the abbreviation for ERβ antagonist, PHT, was misspelled as AZD or ZAD due to an error in Figures 10D, G. And there were incorrect kDa values in the caption due to clerical errors. The corrected Figure 10 and its caption appear below.

Figure 10

In the published article, there were errors in the text. The abbreviation for ERα antagonist, AZD, was misspelled as ZAD due to a clerical error.

In the section, Results, ERα regulated Vglut2 and vgat as a transcription factor, Paragraph 2. This sentence previously stated:

“After injection of ERα agonist into POA of OVX group, the expression of mRNA and protein of Vglut2 increased significantly (90.36 ± 4.69 vs 43.4 ± 3.87, p < 0.001; 73.92 ± 4.85 vs 40.20 ± 3.46, p < 0.001; respectively), which was significantly higher than that in SHAM + AZD (p < 0.05) and OVX + E + ZAD (p < 0.05) groups, while there was no significant difference between SHAM + AZD and OVX + E + ZAD groups (Figures 9CE).”

The corrected sentence appears below:

“After injection of ERα agonist into POA of OVX group, the expression of mRNA and protein of Vglut2 increased significantly (90.36 ± 4.69 vs. 43.4 ± 3.87, p < 0.001; 73.92 ± 4.85 vs. 40.20 ± 3.46, p < 0.001; respectively), which was significantly higher than that in SHAM + AZD (p < 0.05) and OVX + E + AZD (p < 0.05) groups, while there was no significant difference between SHAM + AZD and OVX + E + AZD groups (Figures 9CE).”

In Results, ERα regulated Vglut2 and vgat as a transcription factor, Paragraph 3, the sentence previously stated:

“After injection of ERα agonist into POA of OVX group, the expression of mRNA and protein of Vgat decreased significantly (131.56 ± 8.14 vs 179.2 ± 7.94, p < 0.001; 66.36 ± 4.62 vs 87.72 ± 5.15, p < 0.001; respectively), and there was no significant difference between SHAM + AZD, OVX + PPT and OVX + E + ZAD groups (Figures 9FH).”

The corrected sentence appears below:

“After injection of ERα agonist into POA of OVX group, the expression of mRNA and protein of Vgat decreased significantly (131.56 ± 8.14 vs. 179.2 ± 7.94, p < 0.001; 66.36 ± 4.62 vs. 87.72 ± 5.15, p < 0.001; respectively), and there was no significant difference between SHAM + AZD, OVX + PPT and OVX + E + AZD groups (Figures 9FH).”

In Results, ERβ regulated Vglut2 and Vgat as a transcription factor, Paragraph 2, the sentence previously stated:

“After injection of ERβ agonist into POA of OVX group, the expression of mRNA and protein of Vglut2 increased significantly (65.26 ± 6.25 vs. 54.61 ± 6.92, p < 0.01; 71.25 ± 4.85 vs, 52.64 ± 4.36, p < 0.01, respectively), which was significantly higher than that in SHAM + AZD (mRNA: p < 0.05; protein: p < 0.01) and OVX + E + ZAD (mRNA: p < 0.05; protein: p < 0.01) groups, while there was no significant difference between SHAM + AZD and OVX + E + ZAD groups (Figures 10CE).”

The corrected sentence appears below:

“After injection of ERβ agonist into POA of OVX group, the expression of mRNA and protein of Vglut2 increased significantly (65.26 ± 6.25 vs. 54.61 ± 6.92, p < 0.01; 71.25 ± 4.85 vs, 52.64 ± 4.36, p < 0.01, respectively), which was significantly higher than that in SHAM + PHT (mRNA: p < 0.05; protein: p < 0.01) and OVX + E + PHT (mRNA: p < 0.05; protein: p < 0.01) groups, while there was no significant difference between SHAM + PHT and OVX + E + PHT groups (Figures 10CE).”

In Results, ERβ regulated Vglut2 and Vgat as a transcription factor, Paragraph 3, the sentence previously stated:

“After injection of ERβ agonist into POA of OVX group, the expression of mRNA and protein of Vgat decreased significantly (146.56 ± 8.14 vs. 168.26 ± 7.94, p < 0.05; 72.86 ± 5.81 vs. 93.5 ± 5.21, p < 0.01, respectively), which was still significantly higher than that in SHAM + AZD (mRNA: p < 0.01; protein: p < 0.05) and OVX + E + ZAD (mRNA: p < 0.01; protein: p < 0.05) groups, while there was no significant difference between SHAM + AZD and OVX + E + ZAD groups (Figures 10FH).”

The corrected sentence appears below:

“After injection of ERβ agonist into POA of OVX group, the expression of mRNA and protein of Vgat decreased significantly (146.56 ± 8.14 vs. 168.26 ± 7.94, p < 0.05; 72.86 ± 5.81 vs. 93.5 ± 5.21, p < 0.01, respectively), which was still significantly higher than that in SHAM + PHT (mRNA: p < 0.01; protein: p < 0.05) and OVX + E + PHT (mRNA: p < 0.01; protein: p < 0.05) groups, while there was no significant difference between SHAM + PHT and OVX + E + PHT groups (Figures 10FH).”

The authors apologize for these errors and state that these do not change the scientific conclusions of the article in any way. The original article has been updated.

Statements

Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

Summary

Keywords

hot flashes, glutamatergic neurons, GABAergic neurons, glutamate decarboxylase, thermosensitive transient receptor potentials, estrogen receptors

Citation

Sun Y, Wang H, Wang W, Lu J, Zhang J, Luo X, Luan L, Wang K, Jia J, Yan J and Qin L (2024) Corrigendum: Glutamatergic and GABAergic neurons in the preoptic area of the hypothalamus play key roles in menopausal hot flashes. Front. Aging Neurosci. 16:1072608. doi: 10.3389/fnagi.2024.1072608

Received

17 October 2022

Accepted

17 June 2024

Published

04 July 2024

Volume

16 - 2024

Edited and reviewed by

Jorge Busciglio, University of California, Irvine, United States

Updates

Copyright

*Correspondence: Lihua Qin Junhao Yan Jing Jia

Disclaimer

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

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