ORIGINAL RESEARCH article
Front. Aging Neurosci.
Sec. Alzheimer's Disease and Related Dementias
Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1457160
Association of low-density lipoprotein/high-density lipoprotein ratio with cognition, Alzheimer's disease biomarkers and brain structure
Provisionally accepted
- 1Qingdao Municipal Hospital, Qingdao University Medical College, Qingdao, China
- 2Department of Neurology, Qingdao Municipal Hospital, Qingdao, China
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The relationship between the low-density lipoprotein/high-density lipoprotein (LDL/HDL) ratio, an indicator of lipid metabolism and assessment of cardiovascular disease (CVD) risk, and Alzheimer's disease (AD) is unclear.Methods: Multivariable Cox regression analyses were used to examine the association of LDL/HDL ratio and the risk of AD. Multiple linear regression and mixed effects models used to assess associations between LDL/HDL and cognitive function, AD pathology, and brain structure. Mediation analyses examined AD pathology's potential mediating role between the LDL/HDL ratio and cognition.Results: Higher LDL/HDL ratio correlated with lower AD risk (HR 0.644 [0.431, 0.962]). In the linear regression analyses, the LDL/HDL ratio were positively associated with cognition. Longitudinally, the LDL/HDL ratio also positively with cognitive measures. Besides, higher LDL/HDL ratio were associated Aβ42 and decreased Tau, pTau, Tau/Aβ42, pTau/Aβ42, and pTau/Tau. The LDL/HDL ratio was positively associated with brain structures such as hippocampal volume. Mediation analyses revealed AD pathology mediated the association between LDL/HDL ratio and cognition.The LDL/HDL ratio is associated with AD risk, cognition, AD biomarkers and brain structure and can affect cognition by AD biomarkers.
Keywords: Alzheimer's disease, low-density lipoprotein/high-density lipoprotein, Pathology, Cognition, Brain Structure 3
Received: 30 Jun 2024; Accepted: 21 Apr 2025.
Copyright: © 2025 Zhang, Ma, Huang, Zhu, Guo, Wang, Zhang and Tan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Wei Zhang, Qingdao Municipal Hospital, Qingdao University Medical College, Qingdao, China
Lan Tan, Qingdao Municipal Hospital, Qingdao University Medical College, Qingdao, China
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