ORIGINAL RESEARCH article
Front. Aging Neurosci.
Sec. Neurocognitive Aging and Behavior
Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1566785
This article is part of the Research TopicAdvancing personalized diagnosis and treatment in Parkinson's Disease: Integrating biomarkers, neuroimaging, and artificial intelligenceView all 12 articles
Exploring Cognitive and Emotional symptoms of Hippocampal Subfield Atrophy in Drug-Induced Parkinsonism
Provisionally accepted
- 1Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, China
- 2Nanchong Central Hospital, Nanchong, Sichuan Province, China
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Background: Drug-induced parkinsonism (DIP) is a secondary parkinsonism with limited research on its hippocampal structural changes. This study explores hippocampal subfield volumes in DIP compared to Parkinson's disease (PD) and healthy controls (HCs), investigating correlations with cognitive (Montreal Cognitive Assessment, MoCA), emotional (Hamilton Depression Rating Scale, HAMD; Hamilton Anxiety Rating Scale, HAMA), and motor (Unified Parkinson's Disease Rating Scale, UPDRS) symptoms. Methods: A total of 19 DIP patients, 20 PD patients, and 20 HCs were enrolled. MRIbased hippocampal subfield volumes were assessed using FreeSurfer, and clinical scores were evaluated for cognitive, emotional, and motor functions. Statistical analyses compared group differences and examined correlations. Results: Significant atrophy was observed in the DIP group across hippocampal subfields, including the presubiculum, subiculum, GC-ML-DG, molecular layer, CA4, hippocampal tail, and fimbria. MoCA scores positively correlated with volumes in bilateral hippocampus and subfields such as subiculum and CA1, while HAMD scores mainly showed negative correlations in both DIP and PD group. UPDRS scores revealed group-specific patterns, with DIP showing stronger associations between nonmotor symptoms and hippocampal volume.This study first reported extensive hippocampal subfield atrophy in DIP, distinct from PD, and links structural changes to cognitive, emotional, and motor impairments. These findings advance understanding of DIP pathophysiology and underscore the hippocampus's role in non-motor symptoms.
Keywords: Drug induced parkinsonism, Parkinson Disease, Hippocampus, subfields, cognitive
Received: 25 Jan 2025; Accepted: 13 Jun 2025.
Copyright: © 2025 Zhou, Tang, Cheng, Sun, Lin, Fan, Liu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Shushan Zhang, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, China
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