REVIEW article
Front. Aging Neurosci.
Sec. Neuroinflammation and Neuropathy
Volume 17 - 2025 | doi: 10.3389/fnagi.2025.1578439
This article is part of the Research TopicEstrogens and Neurodegeneration: a Link Between Menopause and Alzheimer’s Diseases in WomenView all 3 articles
From Hormones to Neurodegeneration: How FSH Drives Alzheimer's Disease
Provisionally accepted
- Shandong Provincial Hospital, Jinan, Shandong Province, China
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The role and function of follicle-stimulating hormone in the gonads have been extremely studied. However, recent research has begun to explore the relationship between elevated follicle-stimulating hormone levels and the prevalence of extragonadal disorders, particularly in perimenopausal and postmenopausal women. These disorders include endometrial cancer, osteoporosis, obesity, and atherosclerosis. This review provides new insights into the relationship between follicle-stimulating hormone and the development of age-related diseases, with a focus on Alzheimer's disease. Folliclestimulating hormone does not act alone in promoting Alzheimer's disease but often works in conjunction with inflammation, lipid accumulation, and vascular alterations. Furthermore, folliclestimulating hormone synergizes with obesity, gut microbiota, autophagy, and aging, creating conditions that facilitate the onset and progression of Alzheimer's disease. This review also summarizes the therapeutic potential of FSH-blocking antibodies in treating these diseases.
Keywords: Follicle-stimulating hormone1, Alzheimer's Disease2, aging3, FSH-blocking antibodies4, neuroinflammation5, Lipid Accumulation6
Received: 18 Feb 2025; Accepted: 27 May 2025.
Copyright: © 2025 Xue, Zuo, Wang and Qi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiaoyi Qi, Shandong Provincial Hospital, Jinan, 250021, Shandong Province, China
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