Diling Chen1*
Xin Yang2
Jian Yang1Guoxiao Lai1,3Tianqiao Yong1Xiaocui Tang1Ou Shuai1,4Gailian Zhou3Yizhen Xie1,4*
Qingping Wu1- 1State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Chinese Academy of Sciences, Guangzhou, China
- 2Department of Pharmacy, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
- 3Guangxi University of Chinese Medicine, Nanning, China
- 4Guangdong Yuewei Edible Fungi Technology Co., Ltd., Guangzhou, China
A Corrigendum on
Prebiotic effect of fructooligosaccharides from Morinda officinalis on Alzheimer's disease in rodent models by targeting the microbiota-gut-brain axis
by Chen, D., Yang, X., Yang, J., Lai, G., Yong, T., Tang, X., Shuai, O., Zhou, G., Xie, Y., and Wu, Q. (2017). Front. Aging Neurosci. 9:403. doi: 10.3389/fnagi.2017.00403
In the published article, there was an error in Figure 3E and Figure 6 as published. The H&E image of the brain of OMO-100 in Figure 3E was used incorrectly, and the IHC images in Figure 6 were misused. The corrected Figure 3 and Figure 6 and their captions appear below.
Figure 3. Effect of OMO in Aβ1-42-induced deficient rats. (A) Body weight changes during the treatments time. (B-a) Escape latency in the MWM. (B-b) Swimming distance. (B-c) Swimming time in the platform quadrant during the spatial probe test. (C) Level of cytokines GM-CSF, TNF-γ, 1L-10, IL-12, 1L-17α, 1L-4, TNF-α, and VGEF-α in the serum. (D) Levels of monoamine neurotransmitters (NE, DA, 5-HT, and 5-HIAA) in the brain tissue. (E) Histopathological changes in the intestine, heart, and brain, and the expressions of Aβ1 − 42 and Tau proteins in brain tissues by immunohistochemistry. The graph Control, control group; Model, model group; OMO-50 mg, low-dose group that received D-galactose (100 mg/kg/d) i.p. and gavage at a dosage of 50 mg/[kg·d] in OMO; OMO-100 mg, high-dose group that received D-galactose (100 mg/kg/d) i.p. and gavage at a dosage of 100 mg/[kg·d] in OMO. Values are represented as mean ± SD (n = 6) and expressed as the percentage of the control group, #p < 0.01 vs. control group, *p < 0.05 vs. model group, **p < 0.01 vs. model group.
Figure 6. Immunohistochemistry staining of Foxp3 (A), IL-17 (B), NF-κB p65 (C), and TNF-α (D) in the colons of different experimental groups in high-dose broad spectrum antibiotics and TNBS-induced IBD mice after treatment with OMO.
The authors apologize for these errors and state that they do not change the scientific conclusions of the article in any way. The original article has been updated.
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Keywords: fructooligosaccharides, prebiotics, Alzheimer's disease, behavior, microbiota-gut-brain axis
Citation: Chen D, Yang X, Yang J, Lai G, Yong T, Tang X, Shuai O, Zhou G, Xie Y and Wu Q (2025) Corrigendum: Prebiotic effect of fructooligosaccharides from Morinda officinalis on Alzheimer's disease in rodent models by targeting the microbiota-gut-brain axis. Front. Aging Neurosci. 17:1593725. doi: 10.3389/fnagi.2025.1593725
Received: 14 March 2025; Accepted: 28 April 2025;
Published: 14 May 2025.
Edited and reviewed by: Pradip Pradip Behare, National Dairy Research Institute (ICAR), India
Copyright © 2025 Chen, Yang, Yang, Lai, Yong, Tang, Shuai, Zhou, Xie and Wu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Diling Chen, ZGlsaW5nMTk4M0AxNjMuY29t; Yizhen Xie, eGlleWl6aGVuQDEyNi5jb20=