ORIGINAL RESEARCH article
Front. Aging Neurosci.
Sec. Cellular and Molecular Mechanisms of Brain-aging
This article is part of the Research TopicThe Role of Neurotransmitters: From Normal Aging to Age-Related Diseases, Volume IIView all 3 articles
Gamma-aminobutyric acid associated Research in Parkinson's Disease: An Exploratory Trends Analysis
Provisionally accepted
- 1Hunan University of Chinese Medicine, Changsha, China
- 2Nanjing University of Chinese Medicine, Nanjing, China
- 3Hunan Academy of Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China
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Background: Parkinson's disease (PD) is a neurodegenerative disease characterized by the progressive loss of dopaminergic neurons. Gamma-aminobutyric acid (GABA), as a key inhibitory neurotransmitter, participates in physiological processes such as cognition and motor control by regulating the balance of neuronal excitability. Related studies have found that the GABAergic signaling abnormalities in the basal ganglia and thalamocortical circuits are closely associated with the motor dysfunction and non-motor symptoms of PD. This study aimed to analyze GABA and PD research literature to further identify hotspots, frontiers, and development directions. Method: Data were obtained from the Web of Science, Scopus, and PubMed databases. VOSviewer and CiteSpace were used to visualize and perform quantitative analyses. Results: From 2001 to 2024, a total of 630 publications related to GABA and PD were identified, and the annual publication count fluctuated with an overall upward trend. The United States and China contributed a large number of publications. Karolinska Institute was the leading research institution. Neuroscience published the most papers related to GABA and PD. Dr. Morari, Michele was the most prolific author. The keywords with high frequency focused on the core pathological mechanisms and the imbalance of neurotransmitters, the neural anatomical structure and functional circuits, the main research methods and models, and the treatment strategies. In recent years, α-synuclein, oxidative stress, and anxiety have emerged as research topics with higher burst intensity. Conclusion: This study delineates a comprehensive knowledge structure of GABA and PD research. Enhanced collaboration among authors across institutions and countries is pivotal to advancing the field. The mechanism of GABA in the basal ganglia region is a focus of current research. The detrimental effects of α-synuclein and oxidative stress on the GABAergic system and the non-motor symptom of anxiety are likely to be the frontiers of future research.
Keywords: Basal Ganglia, gamma-Aminobutyric Acid, Oxidative Stress, Parkinson's disease, α-Synuclein
Received: 28 Jun 2025; Accepted: 19 Dec 2025.
Copyright: © 2025 Chen, Ming Rong, Zhou and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Fang Liu
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