Klotho levels in the cerebrospinal fluid may be associated with choroid plexus enlargement in neurodegeneration

Sacchi, Luca; Arcaro, Marina; Bocca, Giorgio; Schmid, Lia; Carandini, Tiziana; Ghezzi, Laura; Pintus, Manuela; Pietroboni, Anna  Margherita; Fenoglio, Chiara; Serpente, Maria; Conte, Giorgio; Triulzi, Fabio  Maria; Lanzarotti, Raffaella; Dolci, Claudia; Galimberti, Daniela; Arighi, Andrea

doi:10.3389/fnagi.2025.1688996

BRIEF RESEARCH REPORT article

Front. Aging Neurosci.

Sec. Alzheimer's Disease and Related Dementias

Klotho levels in the cerebrospinal fluid may be associated with choroid plexus enlargement in neurodegeneration

Provisionally accepted

Luca Sacchi^1*

Marina Arcaro²

Giorgio Bocca¹

Lia Schmid^1,3

Tiziana Carandini²

Laura Ghezzi^1,2

Manuela Pintus²

Anna Margherita Pietroboni²

Chiara Fenoglio^1,2

Maria Serpente²

Giorgio Conte^1,2

Fabio Maria Triulzi^1,2

Raffaella Lanzarotti¹

Claudia Dolci¹

Daniela Galimberti^1,2

Andrea Arighi²

¹Universita degli Studi di Milano, Milan, Italy
²Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
³Universitat Heidelberg, Heidelberg, Germany

The final, formatted version of the article will be published soon.

Luca Sacchi1*, Marina Arcaro2, Giorgio Bocca3, Lia Schmid4,5, Tiziana Carandini2, Laura Ghezzi1, Manuela Pintus2, Anna Margherita Pietroboni2, Chiara Fenoglio1, Maria Serpente2, Giorgio Conte2,6, Fabio Triulzi2,6, Raffaella Lanzarotti5, Claudia Dolci3, Daniela Galimberti1 and Andrea Arighi2 1Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy 2Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy 3Department of Biomedical Sciences for Health, University of Milan, Milan, Italy 4Faculty of Mathematics and Computer Science, University of Heidelberg, Germany 5PHuSe Lab, Department of Computer Science, University of Milan, Italy 6Department of Pathophysiology and Transplantation, University of Milan, Italy

Keywords: Glymphatic system, aquaporin-4, Choroid Plexus, Klotho, Alzheimer's disease

Received: 19 Aug 2025; Accepted: 06 Nov 2025.

Copyright: © 2025 Sacchi, Arcaro, Bocca, Schmid, Carandini, Ghezzi, Pintus, Pietroboni, Fenoglio, Serpente, Conte, Triulzi, Lanzarotti, Dolci, Galimberti and Arighi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Luca Sacchi, luca.sacchi1@unimi.it

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