ORIGINAL RESEARCH article
Front. Aging Neurosci.
Sec. Neuroinflammation and Neuropathy
This article is part of the Research TopicBioactive Compounds for Neuroinflammation and Neuropathic Pain Management: Molecular and Cellular MechanismsView all articles
Mechanistic Insights into the Anti-Neuroinflammatory Effects of Cassia obtusifolia in Parkinson's Disease: A Network Pharmacology-Based Study
Provisionally accepted
- 1Guangdong Provincial Hospital of Chinese Medicine Zhuhai, Zhuhai, China
- 2Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, China
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Background: Parkinson's disease (PD) is a chronic neurodegenerative disorder that is closely associated with neuroinflammation, yet effective anti-inflammatory therapies remain limited. This study aimed to elucidate the potential mechanisms of Cassia obtusifolia in mitigating PD-associated neuroinflammatory responses. Methods: Network pharmacology was employed to identify bioactive compounds, candidate targets, and enriched pathways, followed by protein–protein interaction (PPI) analysis and molecular docking. Rhein, a representative compound, was further validated in LPS-induced BV2 microglial cells using CCK-8, NO detection, ELISA, and Western blot assays. Results: A total of 114 candidate targets were identified, with enrichment highlighting NF-κB, MAPK, and NLRP3 inflammasome pathways. Molecular docking revealed strong binding affinity between rhein and NF-κB p65. In vitro, rhein significantly reduced the production of inflammatory mediators and suppressed p65 phosphorylation in BV2 cells. Conclusion: Cassia obtusifolia exerts multi-target anti-neuroinflammatory effects, supporting its potential as a therapeutic candidate for PD and providing a foundation for further translational studies.
Keywords: Cassia obtusifolia, Parkinson's disease, Neuroinflammation, Networkpharmacology, NF-κB pathway
Received: 23 Oct 2025; Accepted: 02 Dec 2025.
Copyright: © 2025 Lian, Bai, Xie, Du, Ma and Jiang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Yuqian Jiang
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