Frontiers in Aging Neuroscience

Study Protocol

Accepted on 25 Apr 2025

Protocol of a Randomized, Single-Blind, Controlled Trial of an 18-Month, Home-Based, High-Intensity, Exercise Intervention in Older, Cognitively Unimpaired APOE e4 Carriers

in Neurocognitive Aging and Behavior

Stephen M Rao
Alexandria L Chorba
MJ Helppi
Alina Tuladhar
Amanda Penko
Sarah Holley
Brandon Nehls
Sabrina Paulino
Matthew C Streicher
Audrey Zhu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1584115

Original Research

Accepted on 25 Apr 2025

Implications of Heart Rate Variability Measured using Wearable Electrocardiogram Devices in Diagnosing Parkinson's Disease and Its Association with Neuroimaging Biomarkers: A Case-Control Study

in Parkinson’s Disease and Aging-related Movement Disorders

Mincheol Park
Sung-Woo Kim
Jin Yong Hong
Sung Cho
Junghwan Park
Erdenebayar Urtnasan
Min Seok Baek

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1530240

Original Research

Accepted on 25 Apr 2025

Effects of social support on cognitive frailty among the older adults in China: mediation of psychological resilience and moderated mediation of education

in Neurocognitive Aging and Behavior

Wenjuan Li
Yiwen Ma
Jinli Wei
Shanzheng Wu
Liangliang Cui
Chengchao Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1579485

Original Research

Published on 25 Apr 2025

Activation of GLP-1R modulates the spontaneous discharge of nigral dopaminergic neurons and motor behavior in mice with chronic MPTP Parkinson's disease

in Parkinson’s Disease and Aging-related Movement Disorders

Wen-Hong Liu
Cui Liu
Yan Xue
Xiang-Rong Sun
Xin-Yi Chen
Lei Chen

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1529919

107 views

Original Research

Published on 25 Apr 2025

Bioinformatics-driven exploration of key genes and mechanisms underlying oxidative stress in traumatic brain injury

in Neuroinflammation and Neuropathy

Bin Ren
Jifang Liang
Leifang Yang
Xiaocong Wei
Min Guo
Hong Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1531317

Original Research

Published on 25 Apr 2025

Experimental validation and identification of ferroptosis-associated biomarkers for diagnostic and therapeutic targeting in hearing loss

in Neurocognitive Aging and Behavior

Chenyang Yuan
Tianyu Ma
Mengting Liu
Li Jiang
Gongrui Tang
Qi Hu
Tianhong Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1526519

102 views

Original Research

Published on 25 Apr 2025

Lower CALLY index levels indicate higher poor functional outcome risk in acute ischemic stroke patients treated with endovascular thrombectomy

in Neuroinflammation and Neuropathy

Yunnan Lu
Xiaohua Zhu
Yaojia Xu
Yongxin Li
Qingyong Dai
Xia Chang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1587861

123 views

Mini Review

Published on 25 Apr 2025

The potential and challenges of TREM2-targeted therapy in Alzheimer’s disease: insights from the INVOKE-2 study

in Alzheimer's Disease and Related Dementias

Ya-nan Ma
Xiqi Hu
Kenji Karako
Peipei Song
Wei Tang
Ying Xia

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1576020

173 views

Original Research

Accepted on 24 Apr 2025

Mirodenafil Improves Cognitive Function by Reducing Microglial Activation and Blood-Brain Barrier Permeability in ApoE4 KI Mice

in Alzheimer's Disease and Related Dementias

Yejin Park
Subin Moon
Harry Jung
Songyi Park
Ju Won Kim
Dan-Gyeong Song
Yong-Ho In
Sang Won Han
Jong-Hee Sohn
Chan Hee Lee

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1579411

Review

Published on 24 Apr 2025

Neuroprotective effects of electroacupuncture in ischemic stroke: from mechanisms to clinical implications

in Neuroinflammation and Neuropathy

Jinxi Zhu
Xinyi Ge
Yulong Cao
Renjie Xiao
Xiao Deng

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1562925

367 views

Review

Accepted on 23 Apr 2025

Iron Responsive Elements (IREs)-mRNA Regulate Alzheimer's Amyloid Precursor Protein (APP) Translation through Iron Sensing

in Alzheimer's Disease and Related Dementias

Mateen A. Khan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1483913

Original Research

Accepted on 23 Apr 2025

Blood biomarker as surrogate endpoint in Alzheimer's disease research

in Alzheimer's Disease and Related Dementias

Guogen Shan
Hui Li
Yahui Zhang
Guoqiao Wang
Charles Bernick

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1576373

Original Research

Accepted on 23 Apr 2025

Predicting Brain Age for Veterans with Traumatic Brain Injuries and Healthy Controls: An Exploratory Analysis

in Neurocognitive Aging and Behavior

John Philip Coetzee
Xiaojian Kang
victoria Liou-Johnson
Innes Luttenbacher
Srija Seenivasan
Elika Eshghi
Daya Grewal
Siddji Shah
Frank Hillary
Emily L Dennis

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1472207

Systematic Review

Published on 23 Apr 2025

Neural correlates of subjective cognitive decline in Alzheimer’s disease: a systematic review of structural and functional brain changes for early diagnosis and intervention

in Alzheimer's Disease and Related Dementias

Giulia Marafioti
Laura Culicetto
Desirèe Latella
Angela Marra
Angelo Quartarone
Viviana Lo Buono

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1549134

461 views

Original Research

Published on 23 Apr 2025

Machine learning models based on location-radiomics enable the accurate prediction of early neurological function deterioration for acute stroke in elderly patients

in Neurocognitive Aging and Behavior

Xiaoming Fu
Chuanyang Zhang
Hongjie Huang
Changcheng Li
Miaomiao Li
XiaoRan Li
Zhijun Gao
Mingyang Peng
Hui Xu
Wenli Zhu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1582687

428 views

Original Research

Published on 23 Apr 2025

# Language processing characteristics in normal pressure hydrocephalus: insights from eye-tracking analysis of incorrect responses

in Neurocognitive Aging and Behavior

Ji-Yeong Kim
Jiho Lee
Nayeon Kim
Ki-Su Park
Janghyeok Yoon
Kyunghun Kang
Ji-Wan Ha

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1527962

556 views