Frontiers in Aging Neuroscience

Original Research

Published on 22 Jan 2026

Impact of obstructive sleep apnea on gut microbiome of patients with symptomatic intracranial atherosclerotic stenosis

in Neuroinflammation and Neuropathy

Shuoxi Liao
Hui Yang
Li Song
Lingli Shi
Zhike Lan
Wenrong Zhao
Zeyan Bao
Qiongli Hu
Xiaomei Tang
Sidian Zhuang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1713733

471 views

Original Research

Published on 22 Jan 2026

Identification of CTHRC1 as a novel candidate for neurodevelopmental disorders

in Alzheimer's Disease and Related Dementias

Jie Xu
Yuan He
Zhao Li
Wenrong Zhou
Chunjian Huang
Lu Lu
Akhilesh K. Bajpai
Min Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1737003

541 views

Original Research

Published on 22 Jan 2026

Oxytocin reduces anger bias, harm-intention recognition, and self-focus in behavioral variant frontotemporal dementia: a randomized double-blind placebo-controlled crossover trial

in Alzheimer's Disease and Related Dementias

Valentina Colonnello
Sabina Capellari
Maria Guarino
Piero Parchi
Luisa Sambati
Maddalena De Matteis
Michelangelo Stanzani-Maserati
Paolo Maria Russo
Katia Mattarozzi

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1735220

555 views

Original Research

Published on 22 Jan 2026

Multimodal imaging and machine learning for diagnosis of Parkinson’s disease with cognitive impairment: ASL and QSM as potential biomarkers

in Parkinson’s Disease and Aging-related Movement Disorders

Weimin Qi
Jiang Cheng
Xiuping Zhan
Ting Xu
Shue Gu
Qin Shi
Haining Li

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1752040

440 views

Systematic Review

Published on 22 Jan 2026

Effects of different types of deep brain stimulation on gait disorders in patients with Parkinson’s disease: a network meta-analysis of randomized controlled trials

in Parkinson’s Disease and Aging-related Movement Disorders

Yunpeng Guo
Zhanyi Zhang
Yixian Hou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1723706

571 views

Review

Published on 22 Jan 2026

Molecular pathways in vascular cognitive impairment and dementia: focus on synaptic plasticity and epigenetic modifications

in Cellular and Molecular Mechanisms of Brain-aging

Chuanqiang Liu
Fuyue Li
Luyao Qiao
Baichao Kai
Zuobin Wang
Na Zheng
Shengqiao Wang
Ying Gao

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1741558

588 views

Original Research

Accepted on 21 Jan 2026

Cortical Hemodynamic Responses in Older Stroke Patients During a Walking-Based Stroop Dual Task: A Functional Near-Infrared Spectroscopy Study

in Neurocognitive Aging and Behavior

Xiaohan Li
Kai Tang
Yuting Zhang
Lifeng Tang
Kun Wei
Lifeng Zhou
Min Tang

Frontiers in Aging Neuroscience

247 views

Brief Research Report

Accepted on 21 Jan 2026

Alterations in Energy Production in a Drosophila Model for the X-linked Dystonia-Parkinsonism-related Taf1 Deficiency

in Parkinson’s Disease and Aging-related Movement Disorders

Frida Mandik
Philip Seibler
Christine Klein
Melissa Vos

Frontiers in Aging Neuroscience

160 views

Original Research

Accepted on 21 Jan 2026

Lower Hippocampal Volume Partly Mediates the Association Between rs6859 in the NECTIN2 Gene and Alzheimer's Disease: New Findings from Causal Mediation Analysis of ADNI Data

in Alzheimer's Disease and Related Dementias

Aravind Lathika Rajendrakumar
Konstantin G. Arbeev
Olivia Bagley
Anatoliy I Yashin
Svetlana Ukraintseva

Frontiers in Aging Neuroscience

131 views

Original Research

Published on 21 Jan 2026

Older adult solitary drinking: associations with subjective and objective cognitive functioning

in Neurocognitive Aging and Behavior

Carillon J. Skrzynski
Angela D. Bryan

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1678121

1,110 views

Original Research

Published on 21 Jan 2026

Analysis of cognitive function trajectories and influencing factors in elderly patients with ischemic stroke: a prospective longitudinal study

in Neuroinflammation and Neuropathy

Xinhao Chen
Chengxia Wei
Danli Zhao
Chenmei Zhou
Wenjing Wang
Gendi Lu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1733972

449 views

Original Research

Accepted on 20 Jan 2026

Association between End-tidal Sevoflurane Concentration and Postoperative Cognitive Dysfunction and Pain Sensitivity in Elderly Patients under General Anesthesia

in Neurocognitive Aging and Behavior

Yunyun Zhou
Han Zheng
Zhengyu Li
Jiaxuan Wang
Xue Zhang
Lifen Zheng
Hong Luo
Heng Yang

Frontiers in Aging Neuroscience

140 views

Original Research

Published on 20 Jan 2026

Predicting progression from amnestic mild cognitive impairment to Alzheimer's disease using longitudinal EEG data: a 12-month cohort study

in Alzheimer's Disease and Related Dementias

Yingfeng Ge
Yi Fei
Chonglong Ding
Shuo Yang
Yingying Fang
Yifan Zheng
Jianan Yin
Qi Pan
Nanxiang Zhang
Xiaohao Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1719981

700 views

Hypothesis and Theory

Published on 20 Jan 2026

Intrinsic mechanical vibrations as a missing dimension in amyloid-β clearance: a mechanochemical hypothesis for Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Xiaochen Lai

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2026.1749562

715 views

Original Research

Published on 20 Jan 2026

White matter hyperintensities and late-life cognition: an analysis of moderation effects of mild behavioral impairment

in Neurocognitive Aging and Behavior

Jiayu Duan
Ningqun Wang
Shixin Li
Yefei Wang
Jiale Song
Xiaoshan Li
Jingrui Guo
Junya Liao
Yihan Wang
Ying Zhang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1675465

616 views

Review

Published on 20 Jan 2026

Mechanisms to medicines: navigating drug repurposing strategies in Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Sara Akhtar Khan
Khushi Raza
Prachi Tiwari
Mohamed El-Tanani
Syed Arman Rabbani
Suhel Parvez

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1676065

1,114 views

Mini Review

Published on 20 Jan 2026

Human cytomegalovirus infection and cognitive decline: insights from population and experimental studies

in Cellular and Molecular Mechanisms of Brain-aging

Koon Chu Yaiw
Isidre A. Ferrer
Cecilia Söderberg-Nauclér
Dorota Religa

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1757461

574 views

Review

Published on 20 Jan 2026

Intestinal barrier compromise, viral persistence, and immune dysregulation converge on neurological sequelae in Long COVID

in Neuroinflammation and Neuropathy

Laurence Leclerc
Johanne Poudrier
Christopher Power
Grace Y. Lam
Emilia Liana Falcone

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1744415

5,283 views

Hypothesis and Theory

Published on 20 Jan 2026

Therapeutic and preventive strategies based on the maladaptive plasticity hypothesis for Alzheimer’s disease

in Alzheimer's Disease and Related Dementias

Shigeki Kawabata

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1726144

590 views

Original Research

Accepted on 19 Jan 2026

Plasma phospho-tau 217 outperforms plasma phospho-tau 181 analyzed with Lumipulse in detecting Alzheimer's dementia in a real-world memory clinic population

in Alzheimer's Disease and Related Dementias

Michaela Defrancesco
Elke R Gizewski
Ruth Steiger
Irene Virgolini
Alexander Stephan Kroiss
Timo Schurr
Jan Paul Görtz
Josef Marksteiner
Alex Hofer
Christian Humpel

Frontiers in Aging Neuroscience

246 views

Original Research

Accepted on 19 Jan 2026

Towards an understanding of real-world mobility in Parkinson's: insights from enhanced contextualisation using GPS-derived location and data-driven modelling of walking speed

in Parkinson’s Disease and Aging-related Movement Disorders

Cameron John Kirk
Rana Zia UR Rehman
Brook Galna
Saverio Ranciati
Emma Packer
Neil Ireson
Vitaveska Lanfranchi
Claudia Mazzà
Lynn Rochester
Alison J. Yarnall

Frontiers in Aging Neuroscience

238 views

Review

Accepted on 19 Jan 2026

Heat Shock Proteins (Hsp70 and Hsp90) in Neurodegeneration: Pathogenic Roles and Therapeutic Potential

in Cellular and Molecular Mechanisms of Brain-aging

Noureddine Ben Khalaf

Frontiers in Aging Neuroscience

258 views

Systematic Review

Accepted on 19 Jan 2026

Potential protein blood-based biomarkers for cognitive dysfunction in Parkinson's disease: A Systematic Review and network Meta-Analysis

in Parkinson’s Disease and Aging-related Movement Disorders

Youxue Tu
Changmei Lu
Bao Wu
Yuping Yang
Jiapeng Li
Qingping Su
Zhenhua Zhao

Frontiers in Aging Neuroscience

243 views

Original Research

Accepted on 16 Jan 2026

Nightly variations in sleep quality and next-day cognitive performance: an in-home study in healthy older adults

in Neurocognitive Aging and Behavior

Mary Brooks
Randa El Chami
Hugo R. Jourde
Marie-Anick Savard
Emily BJ Coffey

Frontiers in Aging Neuroscience

1,011 views

7,794 articles

articles

Impact of obstructive sleep apnea on gut microbiome of patients with symptomatic intracranial atherosclerotic stenosis

Identification of CTHRC1 as a novel candidate for neurodevelopmental disorders

Oxytocin reduces anger bias, harm-intention recognition, and self-focus in behavioral variant frontotemporal dementia: a randomized double-blind placebo-controlled crossover trial

Multimodal imaging and machine learning for diagnosis of Parkinson’s disease with cognitive impairment: ASL and QSM as potential biomarkers

Effects of different types of deep brain stimulation on gait disorders in patients with Parkinson’s disease: a network meta-analysis of randomized controlled trials

Molecular pathways in vascular cognitive impairment and dementia: focus on synaptic plasticity and epigenetic modifications

Cortical Hemodynamic Responses in Older Stroke Patients During a Walking-Based Stroop Dual Task: A Functional Near-Infrared Spectroscopy Study

Alterations in Energy Production in a Drosophila Model for the X-linked Dystonia-Parkinsonism-related Taf1 Deficiency

Lower Hippocampal Volume Partly Mediates the Association Between rs6859 in the NECTIN2 Gene and Alzheimer's Disease: New Findings from Causal Mediation Analysis of ADNI Data

Older adult solitary drinking: associations with subjective and objective cognitive functioning

Analysis of cognitive function trajectories and influencing factors in elderly patients with ischemic stroke: a prospective longitudinal study

Association between End-tidal Sevoflurane Concentration and Postoperative Cognitive Dysfunction and Pain Sensitivity in Elderly Patients under General Anesthesia

Predicting progression from amnestic mild cognitive impairment to Alzheimer's disease using longitudinal EEG data: a 12-month cohort study

Intrinsic mechanical vibrations as a missing dimension in amyloid-β clearance: a mechanochemical hypothesis for Alzheimer’s disease

White matter hyperintensities and late-life cognition: an analysis of moderation effects of mild behavioral impairment

Mechanisms to medicines: navigating drug repurposing strategies in Alzheimer’s disease

Human cytomegalovirus infection and cognitive decline: insights from population and experimental studies

Intestinal barrier compromise, viral persistence, and immune dysregulation converge on neurological sequelae in Long COVID

Therapeutic and preventive strategies based on the maladaptive plasticity hypothesis for Alzheimer’s disease

Plasma phospho-tau 217 outperforms plasma phospho-tau 181 analyzed with Lumipulse in detecting Alzheimer's dementia in a real-world memory clinic population

Towards an understanding of real-world mobility in Parkinson's: insights from enhanced contextualisation using GPS-derived location and data-driven modelling of walking speed

Heat Shock Proteins (Hsp70 and Hsp90) in Neurodegeneration: Pathogenic Roles and Therapeutic Potential

Potential protein blood-based biomarkers for cognitive dysfunction in Parkinson's disease: A Systematic Review and network Meta-Analysis

Nightly variations in sleep quality and next-day cognitive performance: an in-home study in healthy older adults