Frontiers in Aging Neuroscience

Original Research

Accepted on 21 Aug 2025

Western Diet-induced Visceral Adipose Tissue Inflammation Promotes Alzheimer's Disease Pathology via Microglial Activation in a Mouse Model

Ji Sun Lim
Soyoung Kwak
Mi-Hee Yu
Mee-Na Park
Hye Suk Baek
Junho Kang
Jeongho Hong
Jin Kyung Kim
Hye Won Lee
Sang-Woo Lee

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1644988

Original Research

Accepted on 21 Aug 2025

The mediating role of depression on the association between physical activity and cognitive function among older adults

HuanRui Zhang
Wen Tian
Guoxian Qi
XiuFang Wei

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1470256

Review

Accepted on 20 Aug 2025

Exercise-Mediated Cerebrovascular Repair in Alzheimer's Disease: From Pathophysiology to Therapeutic Precision

Jingyun Hu
Ming Cai
Keren Cai
Ziqi Wei
Jing Zhou
Jiayi Shu
Weiyi Wang
Wanju Sun

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1632365

Review

Published on 20 Aug 2025

Pathophysiological insights and therapeutic developments in age-related hearing loss: a narrative review

Shichu Sun
Qi Zhao
Haojia He
Yujia Liu
Yuchong Nie
You Zhou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1657603

299 views

Original Research

Published on 20 Aug 2025

Age-related trajectories of quality of life in community dwelling older adults: findings from the Survey of Health, Aging and Retirement in Europe (SHARE)

Sarah Mendorf
Konstantin G. Heimrich
Hannah M. Mühlhammer
Tino Prell
Aline Schönenberg

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1632607

417 views

Original Research

Published on 20 Aug 2025

Virtual reality navigation for the early detection of Alzheimer’s disease

Sayuri Shima
Reiko Ohdake
Yasuaki Mizutani
Harutsugu Tatebe
Riki Koike
Atsushi Kasai
Epifanio Bagarinao
Kazuya Kawabata
Akihiro Ueda
Mizuki Ito

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1571429

417 views

Original Research

Published on 20 Aug 2025

Effectiveness of computer-assisted cognitive training on cognitive function and activities of daily living in patients with post-stroke cognitive impairment

Xiaoyang Feng
Xiaolin Sun
Jia Liu
Yan Li
Yunhai Yao
Jianming Fu
Xudong Gu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1590783

199 views

Original Research

Published on 20 Aug 2025

Disrupted calcium dynamics and electrophysiological activity in the stratum pyramidale and hippocampal alveus during fear conditioning in the 5xFAD model of Alzheimer’s disease

Alexander Erofeev
Egor Vinokurov
Anastasia Bol’shakova
Ilya Bezprozvanny
Olga Vlasova

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1550673

324 views

Systematic Review

Published on 19 Aug 2025

Traditional Chinese exercises for motor symptoms and mobility in patients with Parkinson's disease: a systematic review and meta-analysis

Fumei Yuan
Hong Wang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1612913

426 views

Editorial

Published on 19 Aug 2025

Editorial: The open challenges of cognitive frailty: risk factors, neuropsychological profiles and psychometric assessment for healthy aging

Simone Varrasi
Sabrina Castellano
Daniele Magistro

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1679406

351 views

Brief Research Report

Published on 19 Aug 2025

Modulation of fenestrated vasculature in the median eminence and area postrema in response to neurotoxin exposure and its impairment in aging

Viana Q. Pham
Melike Tutunculer
Halah Al-Dulaimi
Daniel Ardjmand
William Fleischmann
Tomas P. Bachor
Allison W. Xu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1634283

694 views

Editorial

Accepted on 18 Aug 2025

Editorial: Multifactorial balance assessment, falls prevention and rehabilitation

Dimitrios Kikidis
Brooke Nairn
Christos Nikitas
Marousa Pavlou
Nattawan Utoomprurkporn
Doris- Eva Bamiou

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1680310

Original Research

Accepted on 18 Aug 2025

Systemic Inflammation versus Clinical Demographics: Patient Age Surpasses the Platelet-to-Lymphocyte Ratio in Differentiating Secondary Trigeminal Neuralgia

Ruen Liu
Zihao Zhang
Qingpei Hao
Tao Wang
Shijun Peng
Xin Chang
Yuepeng Wang
Jia Ouyang

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1658854

Original Research

Accepted on 18 Aug 2025

Association Between Shift Work and Brain Age Gap: A Neuroimaging Study Using MRI-based Brain Age Prediction Algorithms

Youjin Kim
Joon Yul Choi
Evgeny D Petrovskiy
Wanhyung Lee

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1650497

Systematic Review

Published on 18 Aug 2025

Glutamate-associated research in Parkinson’s disease: a bibliometric analysis

Yan-Jun Chen
Ming-Rong Xie
Sheng-Qiang Zhou
Fang Liu

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1569924

432 views

Original Research

Published on 18 Aug 2025

Accelerated midlife endocrine and bioenergetic brain aging in APOE4 females

Tian Wang
Zisu Mao
Yuan Shang
Simona Merlini
Francesca Vitali
Jean-Paul Wiegand
Roberta Diaz Brinton

Frontiers in Aging Neuroscience

doi 10.3389/fnagi.2025.1632877

818 views

7,439 Publications

Volume 17 - 2025

Western Diet-induced Visceral Adipose Tissue Inflammation Promotes Alzheimer's Disease Pathology via Microglial Activation in a Mouse Model

The mediating role of depression on the association between physical activity and cognitive function among older adults

Exercise-Mediated Cerebrovascular Repair in Alzheimer's Disease: From Pathophysiology to Therapeutic Precision

Pathophysiological insights and therapeutic developments in age-related hearing loss: a narrative review

Age-related trajectories of quality of life in community dwelling older adults: findings from the Survey of Health, Aging and Retirement in Europe (SHARE)

Virtual reality navigation for the early detection of Alzheimer’s disease

Effectiveness of computer-assisted cognitive training on cognitive function and activities of daily living in patients with post-stroke cognitive impairment

Disrupted calcium dynamics and electrophysiological activity in the stratum pyramidale and hippocampal alveus during fear conditioning in the 5xFAD model of Alzheimer’s disease

Traditional Chinese exercises for motor symptoms and mobility in patients with Parkinson's disease: a systematic review and meta-analysis

Editorial: The open challenges of cognitive frailty: risk factors, neuropsychological profiles and psychometric assessment for healthy aging

Modulation of fenestrated vasculature in the median eminence and area postrema in response to neurotoxin exposure and its impairment in aging

Editorial: Multifactorial balance assessment, falls prevention and rehabilitation

Systemic Inflammation versus Clinical Demographics: Patient Age Surpasses the Platelet-to-Lymphocyte Ratio in Differentiating Secondary Trigeminal Neuralgia

Association Between Shift Work and Brain Age Gap: A Neuroimaging Study Using MRI-based Brain Age Prediction Algorithms

Glutamate-associated research in Parkinson’s disease: a bibliometric analysis

Accelerated midlife endocrine and bioenergetic brain aging in APOE4 females