Due to a production error, there are two errors in the first column of Table 2: In the column heading of trial 5, “Trial (without antibiotic)” instead of “Trial (with Carbenicillin)”, and in the second trial “#3,, 25°C” instead of “#3, 25°C”.
TABLE 2
| Trial (without antibiotic) | Strain, treatment | Median lifespan (days of adulthood) | S.E. | Observed/total | % Lifespan Change | p-value (log rank) |
|---|---|---|---|---|---|---|
| #1, 25°C | JTL623 (glp-1; eft-3p::tir1), control | 13.42 | 0.56 | 115/120 | ||
| JTL623 (glp-1; eft-3p::tir1), 1 mM auxin (Day 1) | 13.97 | 0.46 | 116/120 | 4.10 | 3.20E-01 | |
| JTL667 (glp-1; eft-3p::tir1; hsf-1::degron), control | 13.12 | 0.38 | 114/120 | |||
| JTL667 (glp-1; eft-3p::tir1; hsf-1::degron), 1 mM auxin (Day 1) | 6.98 | 0.08 | 116/120 | −46.80 | <1e-8 | |
| JTL667 (glp-1; eft-3p::tir1; hsf-1::degron), 1 mM auxin (Day 2) | 8.21 | 0.14 | 116/120 | −37.42 | <1e-8 | |
| JTL667 (glp-1; eft-3p::tir1; hsf-1::degron), 1 mM auxin (Day 3) | 9.38 | 0.2 | 117/120 | −28.51 | <1e-8 | |
| JTL667 (glp-1; eft-3p::tir1; hsf-1::degron), 1 mM auxin (Day 4) | 10.28 | 0.2 | 120/120 | −21.65 | <1e-8 | |
| #1, 25°C | JTL624 (fem-3; eft-3p::tir1), control | 9.23 | 0.15 | 114/120 | ||
| JTL624 (fem-3; eft-3p::tir1), 1 mM auxin (Day 1) | 9.15 | 0.17 | 115/120 | −0.87 | 8.48E-01 | |
| JTL670 (fem-3; eft-3p::tir1; hsf-1::degron), control | 9.44 | 0.16 | 118/120 | |||
| JTL670 (fem-3; eft-3p::tir1; hsf-1::degron), 1 mM auxin (Day 1) | 6.61 | 0.07 | 120/121 | −29.98 | <1e-8 | |
| JTL670 (fem-3; eft-3p::tir1; hsf-1::degron), 1 mM auxin (Day 2) | 7.77 | 0.09 | 120/120 | −17.69 | <1e-8 | |
| JTL670 (fem-3; eft-3p::tir1; hsf-1::degron), 1 mM auxin (Day 3) | 7.92 | 0.11 | 119/120 | −16.10 | <1e-8 | |
| JTL670 (fem-3; eft-3p::tir1; hsf-1::degron), 1 mM auxin (Day 4) | 8.45 | 0.13 | 116/120 | −10.49 | 1.30E-05 |
| Trial (with Carbenicillin) | Strain, treatment | Median Lifespan (days of adulthood) | S.E. | Observed/total | % lifespan change | p-value (log rank) |
|---|---|---|---|---|---|---|
| #2, 25 °C | JTL623 (glp-1; eft-3p::tir1), control | 20.34 | 0.30 | 118/120 | ||
| JTL623 (glp-1; eft-3p::tir1), 1 mM auxin (Day 1) | 20.72 | 0.53 | 61/61 | 1.87 | 8.92E-02 | |
| JTL667 (glp-1; eft-3p::tir1; hsf-1::degron), control | 19.33 | 0.36 | 115/119 | |||
| JTL667 (glp-1; eft-3p::tir1; hsf-1::degron), 1 mM auxin (Day 1) | 6.87 | 0.05 | 120/120 | −64.46 | <1e-8 | |
| #3, 25 °C | JTL667 (glp-1; eft-3p::tir1; hsf-1::degron), control | 18.87 | 0.23 | 97/100 | ||
| JTL667 (glp-1; eft-3p::tir1; hsf-1::degron), 1 mM auxin (Day 1) | 7.28 | 0.06 | 151/151 | −61.42 | <1e-8 | |
| JTL667 (glp-1; eft-3p::tir1; hsf-1::degron), 1 mM auxin (Day 4) | 12.05 | 0.16 | 147/150 | −36.14 | <1e-8 | |
| JTL667 (glp-1; eft-3p::tir1; hsf-1::degron), 1 mM auxin (Day 6) | 14.89 | 0.18 | 147/150 | −21.09 | <1e-8 | |
| JTL667 (glp-1; eft-3p::tir1; hsf-1::degron), 1 mM auxin (Day 8) | 17.36 | 0.19 | 100/100 | −8.00 | 4.90E-07 | |
| #2, 25 °C | JTL624 (fem-3; eft-3p::tir1), control | 9.16 | 0.17 | 121/121 | ||
| JTL624 (fem-3; eft-3p::tir1), 1 mM auxin (Day 1) | 9.75 | 0.13 | 120/120 | 6.44 | 3.82E-02 | |
| JTL670 (fem-3; eft-3p::tir1; hsf-1::degron), control | 9.66 | 0.18 | 120/120 | |||
| JTL670 (fem-3; eft-3p::tir1; hsf-1::degron), 1 mM auxin (Day 1) | 6.33 | 0.05 | 119/120 | −34.47 | <1e-8 |
| Trial (without antibiotic) | Strain, treatment | Median lifespan (days of adulthood) | S.E. | Observed/total | % lifespan change | p-value (log rank) |
|---|---|---|---|---|---|---|
| #4, 20 °C | JTL618 (daf-2; eft-3p::tir1), control | 32.92 | 1.57 | 84/99 | ||
| JTL618 (daf-2; eft-3p::tir1), 1 mM auxin (Day 1) | 33.69 | 1.48 | 87/100 | 2.34 | 6.39E-01 | |
| JTL641 (daf-2; eft-3p::tir1; hsf-1::degron), control | 31.93 | 1.65 | 82/101 | |||
| JTL641 (daf-2; eft-3p::tir1; hsf-1::degron), 1 mM auxin (Day 5) | 20.85 | 0.79 | 94/100 | −34.70 | <1e-8 | |
| JTL641 (daf-2; eft-3p::tir1; hsf-1::degron), 1 mM auxin (Day 7) | 25.47 | 0.79 | 98/100 | −20.23 | 3.60E-08 |
| Trial (with Carbenicillin) | Strain, treatment | Median lifespan (days of adulthood) | S.E. | Observed/total | % lifespan change | p-value (log rank) |
|---|---|---|---|---|---|---|
| #5, 20 °C | JTL618 (daf-2; eft-3p::tir1), control | 42.18 | 1.31 | 112/150 | ||
| JTL618 (daf-2; eft-3p::tir1), 1 mM auxin (Day 1) | 43.41 | 1.25 | 100/150 | 2.92 | 8.10E-01 | |
| JTL641 (daf-2; eft-3p::tir1; hsf-1::degron), control | 40.88 | 1.14 | 98/150 | |||
| JTL641 (daf-2; eft-3p::tir1; hsf-1::degron), 1 mM auxin (Day 7) | 27.07 | 0.67 | 93/150 | −33.78 | <1e-8 | |
| JTL641 (daf-2; eft-3p::tir1; hsf-1::degron), 1 mM auxin (Day 11) | 29.85 | 0.48 | 142/151 | −26.98 | <1e-8 | |
| JTL641 (daf-2; eft-3p::tir1; hsf-1::degron), 1 mM auxin (Day 15) | 32.59 | 0.55 | 121/126 | −20.28 | <1e-8 | |
| JTL641 (daf-2; eft-3p::tir1; hsf-1::degron), 1 mM auxin (Day 19) | 39.22 | 0.52 | 116/119 | −4.06 | 1.10E-07 |
A correction has been made to the section Results.
The publisher apologizes for this mistake. The original version of this article has been updated.
Summary
Keywords
aging, proteostasis, heat shock factor, auxin-inducible degron, temporal-spatial function, core chaperome, lifespan
Citation
Frontiers Production Office (2022) Erratum: Auxin-inducible degron system reveals temporal-spatial roles of HSF-1 and its transcriptional program in lifespan assurance. Front. Aging 3:1006781. doi: 10.3389/fragi.2022.1006781
Received
29 July 2022
Accepted
29 July 2022
Published
12 September 2022
Approved by
Frontiers Editorial Office, Frontiers Media SA, Switzerland
Volume
3 - 2022
Updates
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This article was submitted to Aging, Metabolism and Redox Biology, a section of the journal Frontiers in Aging
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