REVIEW article
Front. Microbiol.
Sec. Microbial Symbioses
Volume 16 - 2025 | doi: 10.3389/fmicb.2025.1542142
The Microbial Landscape of Tumors: A Deep Dive into Intratumoral Microbiota
Provisionally accepted
- 1Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
- 2Dental Research Institute, Tehran University of Medical Sciences, Tehran, Alborz, Iran
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Microorganisms in the human body play crucial roles in various health and disease processes.Research indicates that diverse bacterial species are implicated in numerous cancer types. Apart from its involvement in cancer initiation and progression, the microbiome holds promise as a biomarker for diagnosing cancer, assessing risk, and determining prognosis. Intratumoral microbes profoundly impact tumor biology by regulating the initiation and progression of tumors and modulating their response to chemotherapy, radiotherapy, and immunotherapy. A deeper understanding of the role of the intratumoral microbiome in cancer requires further investigation into its effects and underlying mechanisms. This review delves into the significance of intratumoral bacteria in cancer initiation, progression, and metastasis, their impact on cancer treatment outcomes, and Approaches Employed for Profiling the Intratumoral Microbiome.
Keywords: microbiome, intratumoral microbiota, cancer development, anticancer therapy, epigenetic modification
Received: 09 Dec 2024; Accepted: 30 Apr 2025.
Copyright: © 2025 Asgharzadeh, Pourhajibagher and Bahador. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Abbas Bahador, Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.