MINI REVIEW article
Front. Allergy
Sec. Genetics and Epidemiology
Volume 6 - 2025 | doi: 10.3389/falgy.2025.1583462
This article is part of the Research TopicHereditary alpha-tryptasemia: ten years onView all 4 articles
Hereditary Alpha Tryptasemia and Food Allergy
Provisionally accepted
- Division of Allergy and Immunology, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital, Chicago, United States
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Food allergy (FA) and hereditary alpha-tryptasemia (HαT) are both relatively common conditions, but potential associations between these diagnoses have not been well-studied. Prior studies have suggested that acute rises in tryptase following food allergy reactions may not be as significant as reactions triggered by venom or drug allergy, but preliminary evidence suggests that the presence of αtryptase and HαT is a risk factor for more severe reactions to foods. This mini review summarizes the epidemiology and diagnostic considerations of FA for patients with co-morbid HαT, potential effect of αtryptase on food allergy reaction severity, and implications of tryptase genotyping in the management of FA. Additional research is needed to further investigate the relationship between FA and HαT.
Keywords: food allergy, Hereditary alpha tryptasaemia, TPSAB1 gene, food allergy severity, biomarker, alpha-tryptase
Received: 25 Feb 2025; Accepted: 05 May 2025.
Copyright: © 2025 Lang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Abigail Lang, Division of Allergy and Immunology, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital, Chicago, United States
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