CASE REPORT article
Front. Allergy
Sec. Genetics and Epidemiology
Volume 6 - 2025 | doi: 10.3389/falgy.2025.1587904
This article is part of the Research TopicBradykinin and Histamine Mediated AngioedemaView all 7 articles
Case Report: two cases of hereditary angioedema in a Chinese family
Provisionally accepted
- Tianjin Union Medical Centre, Nankai University, Tianjin, China
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Background: Hereditary angioedema (HAE) is a life-threatening condition characterized by repeated asymmetric cutaneous and mucosal edema. It is a rare autosomal dominant genetic disease with a mortality rate of 8.6%. Family survey of HAE in China is seldom reported since it is still under recognized. Case report: We reported two cases of HAE and a family survey conducted in Hebei Province, China. The proband was a woman who had edema for over 7 years. She was diagnosed with type I HAE in her 50s after a life-threatening asphyxia attack. Her elder brother was initially diagnosed with mild symptoms.Conclusion: Two diagnosed and three suspected patients were identified in our family survey. Family surveys are important method for identifying asymptomatic patients and preventing attacks. It is valuable for rescuing people from sudden death, particularly from asphyxia.
Keywords: Family survey, C1-Inhibitor, case report, Hereditary angioedema (HAE), Bradykinin
Received: 05 Mar 2025; Accepted: 14 May 2025.
Copyright: © 2025 GUO, Qi and Ding. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: YUANLI GUO, Tianjin Union Medical Centre, Nankai University, Tianjin, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.