REVIEW article
Front. Allergy
Sec. Allergy Diagnosis
Volume 6 - 2025 | doi: 10.3389/falgy.2025.1598575
This article is part of the Research TopicInnovations in Allergy Diagnostics and Management: A Global PerspectiveView all 5 articles
From Skin Testing to Molecular Diagnostics: The Precision Leap in Dust Mite Allergy Diagnosis and Clinical Translation Challenges
Provisionally accepted
- 1Wuxi Medical College, Jiangnan University, Wuxi, China
- 2Wuxi Second People’s Hospital, Wuxi, China
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Dust mites are ubiquitous in human living environments and represent the primary source of indoor air allergens worldwide. They are capable of triggering allergic rhinitis, conjunctivitis, asthma, atopic dermatitis, and other allergic conditions. Long-term avoidance of dust mite allergens should decrease sensitization, significantly improves skin lesions, and reduces both the development and severity of respiratory diseases. Therefore, early diagnosis of dust mite allergy is critical for effective treatment and intervention. This review summarizes the existing methods for detecting dust mite allergy, which include both in vivo and in vitro approaches-such as skin prick testing(SPT), atopy patch testing(APT), provocation tests, basophil activation test (BAT), and molecular component-resolved diagnostics(CRD)-and analyzes the underlying principles, advantages, and limitations of each method to serve as a reference for the development of future detection methods.
Keywords: Dust mite allergy1, Skin testing2, Molecular diagnostics3, In vivo experiment4, In vitro experiments5, Detection methods6
Received: 23 Mar 2025; Accepted: 13 May 2025.
Copyright: © 2025 Han, Ge, Luo, Zhou and Wen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ming Han, Wuxi Medical College, Jiangnan University, Wuxi, China
Xiaoli Ge, Wuxi Second People’s Hospital, Wuxi, China
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