MINI REVIEW article
Front. Allergy
Sec. Mechanisms in Allergy
Volume 6 - 2025 | doi: 10.3389/falgy.2025.1609120
This article is part of the Research TopicUpdate on Eosinophil-associated diseasesView all 4 articles
Inhalation and Inflammation: Examining Aeroallergens and Eosinophilic Esophagitis
Provisionally accepted
- 1MedStar Georgetown University Hospital, Washington D.C., District of Columbia, United States
- 2George Washington University Hospital, Washington, D.C., District of Columbia, United States
- 3Washington DC VA Medical Center, United States Department of Veterans Affairs, Washington D.C., United States
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Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease leading to inflammation in the esophageal lining. EoE has become a significant cause of gastrointestinal illness in both children and adults. While there is significant focus on dietary triggers in the pathophysiology of the disease, aeroallergens are also increasingly implicated in both the development and clinical presentation. Possible mechanisms, seasonality and current evidence for the role of aeroallergens in EoE are discussed, including seasonality, allergen specific mechanisms and therapeutic options. A multidisciplinary team between allergists and gastroenterologists is optimal for coordinated patient management.
Keywords: Eosinophilic Esophagitis, Allergens, Pollen, seasonal allergies, Aeroallergens
Received: 10 Apr 2025; Accepted: 29 May 2025.
Copyright: © 2025 Sekar, Kelly, Sheth and Papademetriou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Marianna Papademetriou, Washington DC VA Medical Center, United States Department of Veterans Affairs, Washington D.C., United States
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