REVIEW article
Front. Allergy
Sec. Infections and Microbiome
Volume 6 - 2025 | doi: 10.3389/falgy.2025.1631479
Title：Gut Microbiota-Metabolome Crosstalk in Allergic Diseases: 1Mechanistic Insights and Translational Opportunities
Provisionally accepted
Han Bin Qin1,2
Jiaxin Sui2,3
shuang wang1,2xiaojing lv2,3zile zhang2,4
Lin Xinhua1,2xuexia liu5*
Hua Zhang2*- 1Shandong Second Medical University, Weifang, China
- 2Department of Otolaryngology Head and Neck Surgery, Yantai Yuhuangding Hospital, Yantai, Shandong Province, China
- 3Qingdao University, Qingdao, Shandong Province, China
- 4Binzhou Medical University, Binzhou, Shandong Province, China
- 5Yantai Yuhuangding Hospital, Yantai, Shandong Province, China
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The gut microbiota and its metabolites play important roles in the pathogenesis of various diseases. The diversity of the gut microbiota is closely related to the development and function of the human immune system. Dysbiosis, characterized by alterations in the species, quantity, and distribution of microbial community, may disrupt immune tolerance mechanisms, thereby inducing excessive immune responses to allergens and increasing the risk of allergic diseases. Various metabolites, such as short-chain fatty acids (SCFAs), bile acids, and amino acid metabolites, exert significant regulatory effects on the development of allergic diseases by modulating immune cell function, maintaining intestinal barrier integrity, and participating in signal transduction pathways. A comprehensive investigation into the relationship between allergic diseases and gut microbiota and their metabolites not only aids in elucidating the pathogenesis of allergic diseases but also provides novel insights and a theoretical foundation for developing innovative diagnostic methods, preventive strategies, and therapeutic options. This article systematically reviews the latest findings regarding the mutual influence between gut microbiota and the metabolome in host immune regulation, as well as the impact of this interaction on the development of allergic diseases, aiming to offering new strategies for the prevention and treatment of allergic diseases.
Keywords: allergic diseases, Gut Microbiota, Metabolome, Microbiota dysbiosis, Mechanisms of immunity
Received: 19 May 2025; Accepted: 26 Jun 2025.
Copyright: © 2025 Qin, Sui, wang, lv, zhang, Xinhua, liu and Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
xuexia liu, Yantai Yuhuangding Hospital, Yantai, Shandong Province, China
Hua Zhang, Department of Otolaryngology Head and Neck Surgery, Yantai Yuhuangding Hospital, Yantai, Shandong Province, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.