Use of Oral Corticosteroids in Patients with Asthma: How Far is Clinical Practice From the Guidelines? Results from Surveys of Patients and Doctors

Luisa Brussino¹Gianna Camiciottoli²Annalisa Stassaldi³Diego Bagnasco⁴Simona Barbaglia⁵Maria Beatrice Bilò⁶Cristiano Caruso⁷Filippo Cipriani⁸Renato Cutrera⁹Giuliana Nicolosi⁸Jasmine Nour^3*Giulia Scioscia¹⁰Giorgio Walter Canonica¹¹

• ¹Universita degli Studi di Torino, Turin, Italy
• ²Universita degli Studi di Firenze, Florence, Italy
• ³Sanofi S.p.A., Milan, Italy
• ⁴Universita degli Studi di Genova, Genoa, Italy
• ⁵RESPIRIAMO INSIEME-APS, Padova, Italy
• ⁶Universita Politecnica delle Marche, Ancona, Italy
• ⁷Fondazione Policlinico Universitario A. Gemelli - IRCCS, Rome, Italy
• ⁸Sanofi Spa, Milan, Italy
• ⁹Ospedale Pediatrico Bambino Gesu IRCCS, Rome, Italy
• ¹⁰Universita degli Studi di Foggia, Foggia, Italy
• ¹¹Humanitas University, Milan, Italy

Introduction: Asthma is often treated with oral corticosteroids (OCS), despite their association with significant adverse effects. While guidelines recommend minimizing OCS use through alternative therapies and patient-centered approaches, discrepancies between recommendations and real-world practices persist. This study evaluates OCS usage patterns and barriers to adherence to asthma treatment guidelines in Italy, using surveys conducted with healthcare professionals (HCPs) and patients. Methods: Two cross-sectional surveys were administered between January and March 2024 to HCPs and asthma patients. The surveys assessed OCS prescription practices, treatment adherence, patient involvement, adverse event management, and perceptions of OCS use. Descriptive analysis was performed to identify patterns and highlight gaps in current practices. Results: The surveys revealed considerable variability in OCS prescribing practices, treatment duration and daily dosages. Over 80% of patients reported using OCS and 18% of HCPs believed that the maximum daily doses of OCS are higher than the guideline-recommended doses. Patients did not feel fully involved in treatment decisions, with over 40% of patients reporting unsatisfactory communication about treatment alternatives or adverse effects. Barriers to optimal care included inadequate access to specialists, inconsistent monitoring protocols, and a lack of multidisciplinary approaches. Both HCPs and patients highlighted the need for clearer definitions of OCS dependency and enhanced tools for tracking treatment adherence. Discussion: The findings underscore the urgent need for systemic reforms to align clinical practice with guidelines. These include establishing pragmatic definitions for OCS dependency, promoting multidisciplinary care, and leveraging technology for monitoring. Addressing psychosocial factors and empowering patients through education and shared decision-making are also critical.