REVIEW article
Front. Allergy
Sec. Allergen Immunotherapy
Volume 6 - 2025 | doi: 10.3389/falgy.2025.1667696
This article is part of the Research TopicNavigating the complexities of severe allergic reactions: Current challenges and future directionsView all articles
The Multidimensional Dilemmas and Integrative Strategies of Pediatric Allergen Immunotherapy
Provisionally accepted
- School of Pediatric Medicine, Henan University of Traditional Chinese Medicine, Zhengzhou, China
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The high prevalence of pediatric allergic diseases constitutes a significant public health challenge. Allergen Immunotherapy (AIT), the sole intervention capable of modifying the disease's natural course, faces three core contradictions in its pediatric application: 1) The conflict between standardized protocols and the highly individualized allergic phenotypes and immune endotypes of pediatric patients, which hinders the implementation of personalized precision medicine; 2) The imbalance between the long-term immunological benefits pursued by AIT and the short-term clinical risks and adherence barriers, which seriously compromises treatment continuity and ultimate efficacy; 3) The challenge of reversing an established allergic state versus addressing primordial immune dysregulation in early disease development, revealing the profound complexity of immune intervention.Drawing upon an analysis of frontier research in precision diagnostics, treatment adherence, and mechanisms of immune reconstitution, this paper proposes that overcoming the current bottlenecks hinges on constructing and implementing an "integrative therapeutic strategy." This strategy emphasizes the organic integration of three core pillars: 1) individualized, precision regimens guided by novel biomarkers; 2) a systematic and humanistic closed-loop adherence management system; and 3) a profound understanding and clinical application of the unique plasticity and intrinsic laws of the pediatric immune system.The value of this study lies in providing a clear theoretical framework for systematically addressing the multidimensional challenges of pediatric AIT. It also offers explicit pathways for optimizing clinical practice and guiding future research with high translational potential, with the ultimate goal of significantly improving the long-term health outcomes and quality of life for allergic children worldwide.
Keywords: Pediatric Allergen Immunotherapy (AIT), Integrative strategy, precision medicine, Component-Resolved Diagnostics(CRD), Treatment Adherence, Immune reconstruction, Immune Tolerance, Allergic march
Received: 18 Jul 2025; Accepted: 19 Sep 2025.
Copyright: © 2025 CHEN, Ying, Han, Xu, Wang, Guo and Wei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Ding Ying, dingying3236@aliyun.com
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