REVIEW article
Front. Allergy
Sec. Skin Allergy
Volume 6 - 2025 | doi: 10.3389/falgy.2025.1668931
Advances of Bispecific Antibodies Using/Application in Dermatology: A Review
Provisionally accepted
- Tianjin University of Traditional Chinese Medicine, Tianjin, China
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Bispecific antibodies represent an important innovation in the field of biomedicine in recent years. Compared to monoclonal antibodies,their specific structure enables a single antibody molecule to bind to two different antigens simultaneously. This characteristic endows bispecific antibodies with more functions, regulating multiple signal pathways simultaneously, enhancing the therapeutic effect, and by infusion of targeted tumor antigens and drug carriers in advance, the contact time between the drug and normal tissues is reduced, and the toxic side effects are greatly reduced.They have shown promising application prospects, especially in dermatology and other fields. This article reviews the basic concepts of bispecific antibodies and their potential application in the treatment of skin diseases, including inflammatory skin diseases, skin tumors, and infectious skin diseases. The aim is to explore the current application status and future development directions of bispecific antibodies in dermatology, so as to provide references for related research and clinical practice.
Keywords: bispecific antibodies, Inflammatory skin diseases, Skin tumors, Skin infections, Dermatology
Received: 18 Jul 2025; Accepted: 05 Aug 2025.
Copyright: © 2025 Zhang, Liu, Liew, Zhang and Zhao. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Yu Zhang, Tianjin University of Traditional Chinese Medicine, Tianjin, China
Zuotao Zhao, Tianjin University of Traditional Chinese Medicine, Tianjin, China
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.