REVIEW article
Front. Allergy
Sec. Asthma
This article is part of the Research TopicThe Role of Epithelial-Derived Cytokines in Airway DiseaseView all 6 articles
Potential of alarmin targeted bispecific and combination therapies in airway disease
Provisionally accepted
- 1Uniquity Bio, San Diego, United States
- 2Pulmore Sciences, San Diego, United States
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Thymic stromal lymphopoietin (TSLP), IL-33 and IL-25 are epithelial derived proinflammatory alarmin cytokines that drive inflammatory airway diseases such as asthma and chronic obstructive pulmonary disease (COPD). Targeted inhibition of these proteins have demonstrated varying degrees of efficacy in patients with asthma and COPD. As the biology of inflammatory respiratory disease is complex, combination approaches that directly inhibit multiple targets may provide deeper efficacy in a broader patient population. Here, we review the biology of alarmins and the development landscape for monotherapies and multispecific alarmin inhibitors.
Keywords: TSLP, IL-33 and ST2, IL-25, Asthma, COPD - Chronic obstructive pulmonary disease, biologics, Alarmin Cytokines, Clinical development
Received: 05 Sep 2025; Accepted: 06 Nov 2025.
Copyright: © 2025 Komori and Ortega. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Heather Kiyomi Komori, kiyomi.komori@uniquity.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.