EDITORIAL article
Front. Allergy
Sec. Skin Allergy
This article is part of the Research TopicBiomarkers in Allergic EczemaView all 10 articles
Editorial: Biomarkers in Allergic Eczema
Provisionally accepted
- 1Touro College of Osteopathic Medicine - Montana, Great Falls, MT 59405, United States
- 2New York Medical College, Valhalla, United States
- 3Boehringer Ingelheim Pharmaceuticals, Ridgefield, United States
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Sargen et al. identified emerging diagnostic and prognostic biomarkers in allergic contact dermatitis (ACD)-including ADAM8, CD47, IL-37, and loricrin. Sasaki et al. proposed neuroimmune mediators such as IL-31 and TRPV1 as therapeutic targets in ACD. Collectively, both reviews emphasize integrating skin and blood biomarker networks, multi-omics and longitudinal cohort validation in advancing personalized management of allergic and inflammatory skin diseases across ages. Maskey et al. reported topical steroid withdrawal (TSW) as an emerging inflammatory syndrome following chronic corticosteroid use. They discussed mechanisms involving nitric oxide-mediated vasodilation, epidermal cortisol dysregulation, microbiome imbalance, and cytokine rebound as prime drivers of TSW. They advocate clinical recognition, diagnostic refinement, and multidisciplinary management, including gradual tapering, skin barrier repair, and mental health support to reduce development of TSW. Song et al. explored systemic inflammatory burden as a biomarker of eczema in 3,397 children and adolescents using the NHANES database. This study introduced SIRI as a promising, easily measurable biomarker for systemic immune balance in allergic skin diseases. They showed higher SIRI (systemic inflammatory response index) levels inversely associated with eczema prevalence suggesting a potential protective immunological balance. The authors proposed that elevated SIRI may reflect Th1 or regulatory T cell activity counteracting Th2-driven 39 40 multitude of therapeutic options both in range and effectiveness, along with the patient stratification, 58 allows for personalized, proactive strategies and biomarker-driven approaches that reduce the 59 financial and emotional burden of the disease on the patients and their caregivers. 60 To investigate the function of mast cells in an in-situ environment, Villanueva, et al. investigated the 61 use of intact human skin explant tissue to study human mast cell activation. Their Methods paper 62 describes the development and application of this full-thickness human skin specimen model. 63Spontaneous histamine release was investigated, as well as with induced FceR1 and MRGPRX2 64 activation. The use of acalabrutinib, QWF and pertussis toxin to inhibit histamine release contributed 65 to the verification of normal mast cell function. The use of "human skin punch biopsy discards" 66 opens the way for in-situ investigations of mast cells functioning and therapeutic inhibition. 67The intake, metabolism and use of vitamin B6 is important for brain function and the immune 68 system. The role of vitamin B6 and its metabolites in eczema is understudied.
Keywords: biomarker, Eczema, personalized therapy, Th2 (type-2) immune responses, Endotype
Received: 18 Nov 2025; Accepted: 24 Nov 2025.
Copyright: © 2025 Maskey, Bharadwaj and Geliebter. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Anish Raj Maskey, amaskey@student.touro.edu
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