ORIGINAL RESEARCH article
Front. Artif. Intell.
Sec. Medicine and Public Health
This article is part of the Research TopicAI Paradigm for Sustainable Development in Health Care and the Associated Social ImplicationsView all articles
XAI-BT-EdgeNet: Explainable Edge-Aware Deep Learning with Squeeze-and-Excitation for Brain Tumor Detection and Prediction
Provisionally accepted- 1School of Computer Science and Engineering, IILM University, Greater Noida, India
- 2School of Computer Science and Engineering, Galgotias University, Greater Noida, India
- 3Department of Civil, Environmental, Mechanical Engineering University of Trento, Trento, Italy
- 4Radiomics Laboratory, Department of Economy and Management, University of Trento, Trento, Italy
- 5Department of Computer Science and Engineering, JIIT, Noida, India
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
Accurate and early detection of brain tumors is critical for effective treatment and improved patient outcomes, yet manual radiological analysis remains time-consuming, subjective, and error-prone. To address these challenges and improve clinical trust in AI systems, this study presents XAI-BT-EdgeNet, an explainable, edge-aware deep learning framework integrated with Squeeze-and-Excitation (SE) modules for brain tumor detection using MRI scans. The architecture employs a dual-branch design that fuses high-level semantic features from InceptionV3 with low-level edge representations via an Edge Feature Block, while SE modules adaptively recalibrate feature importance to enhance diagnostic accuracy. To ensure transparency, the model incorporates four XAI techniques—LIME, Grad-CAM, Grad-CAM++, and Vanilla Saliency, which provide interpretable visual justifications for predictions. The framework was trained and evaluated on the Brain Tumor Dataset by Preet Viradiya, comprising 4,589 labeled MRI images divided into Brain Tumor (2,513) and Healthy (2,076) classes. The model achieved outstanding results, with 99.58% training accuracy, 99.71% validation accuracy, and 100.00% testing accuracy, alongside minimal loss values of 0.0103, 0.0051, and 0.0026, respectively. This work includes, the development of a dual-branch CNN architecture that combines semantic and edge features for enhanced classification, the integration of SE modules to highlight clinically significant regions, and the application of multi-method XAI to offer transparent, interpretable outputs for clinical applicability. Overall, XAI-BT-EdgeNet delivers a high-performing, interpretable solution that bridges the gap between deep learning and trustworthy clinical decision-making in brain tumor diagnosis.
Keywords: brain tumor, Magnetic Resonance Imaging, deep learning, Edge aware, Squeeze and excitation, Explainable Interpretability
Received: 30 Jul 2025; Accepted: 31 Oct 2025.
Copyright: © 2025 Rastogi, Johri, Donelli, Agarwal, Tiwari and Singh. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Deependra  Rastogi, deependra.libra@gmail.com
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
