BRIEF RESEARCH REPORT article
Front. Bioinform.
Sec. RNA Bioinformatics
Volume 5 - 2025 | doi: 10.3389/fbinf.2025.1633494
This article is part of the Research TopicAI in RNA ScienceView all articles
Association between Dysregulated Expression of Ca 2+ and ROS-Related Genes and Breast Cancer Patient Survival
Provisionally accepted
- CBIOS, Universidade Lusófona Research Center for Biosciences & Health Technologies, Lisbon, Portugal
Select one of your emails
You have multiple emails registered with Frontiers:
Notify me on publication
Please enter your email address:
If you already have an account, please login
You don't have a Frontiers account ? You can register here
The intricate interplay between Ca 2+ and reactive oxygen species (ROS) signalling systems influences numerous cellular pathways. Dysregulated expression of genes associated with Ca 2+ and ROS homeostasis can significantly impact cancer progression. Despite extensive research, various underlying mechanisms remain elusive, lacking a comprehensive unified perspective. Breast cancer (BC) remains the leading cause of cancer-related deaths among women, highlighting the pressing need to discover novel regulatory mechanisms, therapeutic targets, and potential biomarkers. In this study, we employed a bioinformatic approach based on data from The Cancer Genome Atlas to assess the association between combined dysregulation of specific pairs of genes involved in redox-or Ca 2+related cellular homeostases and patient outcome. These genes were selected by differences in their expression between normal and tumour tissues and in their individual association with patient survival rates. Cumulative proportion survival at the 5-year post-diagnosis was calculated for each quartile of expression within the population exhibiting either high or low expression of a second gene. Additional genes with expression positively or negatively correlated with the set of relevant gene pairs were identified, and a gene enrichment analysis was performed. Our results show that the simultaneous dysregulation of a selected number of gene pairs is substantially associated with BC patient survival. Notably, the expression dysregulation of these gene pairs is associated with altered expression of genes linked to cell cycle regulation, cell adhesion, and cell projection processes. This approach exhibits a significant potential to identify new prognostic biomarkers or drug targets for BC.
Keywords: breast cancer, Gene Expression, Reactive Oxygen Species, calcium (Ca 2+ ), Patient survival
Received: 22 May 2025; Accepted: 05 Aug 2025.
Copyright: © 2025 Ramos, Gregório, Fernandes and Saraiva. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
Ana Sofia Fernandes, CBIOS, Universidade Lusófona Research Center for Biosciences & Health Technologies, Lisbon, Portugal
Nuno Saraiva, CBIOS, Universidade Lusófona Research Center for Biosciences & Health Technologies, Lisbon, Portugal
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.