Frontiers in Bioinformatics

Original Research

Accepted on 11 Aug 2026

IN SILICO AND IMMUNOINFORMATIC APPROACH TO DESIGN A MULTI-EPITOPE MRNA VACCINE TARGETING ALL MAJOR HUMAN-INFECTING GENOTYPES OF HEPATITIS E VIRUS

in Drug Discovery in Bioinformatics

Maham Mehrangaze Khonza
Zain Saeed
Zohra Jabeen
Wafaa Arab
Sehrish Kakakhel
Maham Yamin
MAZEN GHAITH
Ali Zohaib
Aneela Javed
Rwaa H. Abdulal

Frontiers in Bioinformatics

Original Research

Accepted on 11 Aug 2026

DZIP3 is associated with the cytoskeletal dynamics in glioblastoma and mitochondrial machinery regulation

in Protein Bioinformatics

Khadija Bichri
Meryeme Chihab Eddine
Mohammed Sqalli Houssaini
Mounir Rghioui
Imad El Badisy
Bouchra GHAZI

Frontiers in Bioinformatics

Original Research

Accepted on 11 Aug 2026

Gene functions determine stochastic or adaptive futile transcription in cancers through deregulated start site deployments

in Integrative Bioinformatics

Aditi Lakshmi Satish
Praveen Kumar
Ishani Morbia
Umashankar Singh

Frontiers in Bioinformatics

Technology and Code

Published on 11 Aug 2026

PUDU (pipeline for universal diversity unveiling): an accessible end-to-end workflow for taxonomic profiling and ecological visualization of environmental microbiomes across amplicon, shotgun, and long-read sequencing

in Integrative Bioinformatics

Alejandro Medaglia-Mata
Pablo Rojas-Rodríguez
Vojtěch Bystrý
Rossy Guillén-Watson
Olman Gómez-Espinoza
Kattia Núñez-Montero

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1909327

292 views

Correction

Published on 11 Aug 2026

Correction: Transcriptome-informed metabolic modeling reveals astrocyte-specific vulnerabilities in mild cognitive impairment and Alzheimer’s disease progression

in Integrative Bioinformatics

Andrea Angarita-Rodríguez
Viviana Vargas-López
Andrés Pinzón
Adrián Sandoval-Hernandez
Kai Kang
Leping Li
Jason Papin
Pedro Puentes-Rozo
Andrés Felipe Aristizábal
Janneth González

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1953979

115 views

Original Research

Published on 11 Aug 2026

Design and in silico evaluation of Thiazole–Isoxazole hybrids as PPARγ-Targeted antidiabetic agents

in Drug Discovery in Bioinformatics

Abhirami PV
Gupta Dheeraj Rajesh
N. V. L. Sirisha Mulukuri
Ranjitha A
Niyas Rehman
Shiv Basant Kumar
Dileep Kumar
Pankaj Kumar

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1873262

444 views

Original Research

Accepted on 10 Aug 2026

Conformational Dynamics of Fuzzy Interfaces in Disordered Protein Complexes: Mapping Key Residues and Binding Modes Beyond NMR Models

in Protein Bioinformatics

María Laura Fernández
María Clara Bastien
Franco G. Tavolaro
Cristina Marino-Buslje

Frontiers in Bioinformatics

Original Research

Accepted on 10 Aug 2026

Alternative Splicing Remodeling and Splicing Factor Regulatory Networks Define Immune-Associated Molecular Heterogeneity in Dilated Cardiomyopathy

in Integrative Bioinformatics

Jia Li
Yiyu He
Xianxian Zhao
Zhifu Guo
Jinchao Song
Xiaowei Song

Frontiers in Bioinformatics

Original Research

Accepted on 10 Aug 2026

Revealing RELL1 signaling relying on the phosphoregulatory network analysis

in Protein Bioinformatics

Pathiyil Sajini Sekhar
DIYA SANJEEV
Amal Fahma
Suhail Subair
Athira Perunelly Gopalakrishnan
PRATHIK B S
Rajesh Raju
Sowmya Soman

Frontiers in Bioinformatics

Original Research

Accepted on 10 Aug 2026

Integration of Resolving Topological Indices and ADMET Analysis with MCDM Methods (TOPSIS and SAW) for Ranking Breast Cancer Therapeutics

in Drug Discovery in Bioinformatics

Pandeeswari E
Ravi Sankar J

Frontiers in Bioinformatics

Opinion

Accepted on 10 Aug 2026

Ten Key Considerations for Developing Interpretable Risk Prediction Models

in Integrative Bioinformatics

Xi Zhang
Wenjie Xu
David Roy Smith

Frontiers in Bioinformatics

Original Research

Published on 10 Aug 2026

Multiple binding modes underlie Cannabis sativa cannabinoids recognition by peroxisome proliferator-activated receptor gamma

in Drug Discovery in Bioinformatics

N. R. Carina Alves
Justina Miranda
Lautaro D. Alvarez

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1893303

336 views

Original Research

Published on 10 Aug 2026

LungMicroHostR: an R package for integrated host–microbiome analysis of bronchoalveolar lavage fluid metagenomic sequencing data

in Integrative Bioinformatics

Nan Li
Jing Hu
Wanning Tong
Chengdong Liu
Yun Ding
Ning Li
Zhigang Cai

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1906036

298 views

Original Research

Accepted on 07 Aug 2026

All-atoms MD simulations study of newly designed ciprofloxacin derivatives as potential bacterial DHPS and DNA gyrase inhibitors

in Drug Discovery in Bioinformatics

Chita Ranjan Sahoo
Madhusmita Rout
SUDHIR KUMAR PAIDESETTY
Dr. Budheswar Dehury
DEBDUTTA BHATTACHARYA
Sanghamitra Pati

Frontiers in Bioinformatics

115 views

Original Research

Accepted on 07 Aug 2026

Establishing Standardized Evaluation Protocols for Peptide-Target Interaction Prediction: The PTI-TAPE Consensus Framework eDelphi

in Protein Bioinformatics

William Waldock
Guangshun Wang
Ara Darzi
Cesar de la Fuente-Nunez
Hutan Ashrafian

Frontiers in Bioinformatics

Original Research

Published on 07 Aug 2026

AI-enhanced virtual screening identifies a potent small-molecule modulator of ClC-3 for cervical cancer drug discovery

in Drug Discovery in Bioinformatics

Chao Liu
Chongxing Ji

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1887419

373 views

Original Research

Published on 07 Aug 2026

Integrated analysis of enzymes, mRNAs, and miRNAs provides insight into the regulatory potential of extracellular vesicles in recipient cell glucose metabolism

in Integrative Bioinformatics

Namita N. Kashyap
Sharath Mohan Bhat
Padmanabha Udupa E. G.
Kavitha S. Shettigar
Vinutha R. Bhat
Dinesh Upadhya

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1911554

439 views

Original Research

Accepted on 06 Aug 2026

Evaluation of functional annotation-informed and ancestry-specific polygenic risk scores for ischemic stroke

in Genomic Analysis

Nicole D. Armstrong
Vinodh Srinivasasainagendra
Amit Patki
Lavanya Pilla
Chad Aldridge
Alana Jones
Ulrich Broeckel
Ethan M. Lange
Leslie A. Lange
Pankaj Arora

Frontiers in Bioinformatics

Original Research

Accepted on 06 Aug 2026

REACH: A Reproducible Benchmark for Inter-Lineage Rare Malignant Cell Detection in Single Cell RNA Sequencing

in Integrative Bioinformatics

Moram Venkata Satya Jaswanth
Amruthaluri Gavin
Padarthi Aakash
Muttha Tejesh Kumar
Abhijit Dasgupta

Frontiers in Bioinformatics

Original Research

Published on 06 Aug 2026

Spatial transcriptomics reveal heterogeneous cell‒cell interactions among brain regions in cuprizone model consistent with multiple sclerosis lesions

in Single Cell Bioinformatics

Hui-Hsin Tsai
Sarbottam Piya
Jing Wang
Jing Zhu
Wenxing Hu
Andrew R. Gehrke
Shaolong Cao
Amanda J. Guise
Su Jing Chan
Mark Sheehan

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1832826

604 views

Original Research

Accepted on 05 Aug 2026

Assessment of the Impact of Manual Curation in BioCyc

in Genomic Analysis

Ron Caspi
Brendan Wilson-Mortier
Lisa R Moore
Dylan Beesley
Ian T Paulsen
Peter D Karp

Frontiers in Bioinformatics

Original Research

Published on 05 Aug 2026

SiaRNA: a siamese neural network with bidirectional cross-attention for pairwise siRNA-mRNA efficacy prediction

in Drug Discovery in Bioinformatics

Vaishnavi Sapireddy
Rajkumar Nathi
Venkata Harshit Meruva
Varun Raju Nannapuraju
Bhargava Chary Basangari
Vani Kondaparthi

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1827877

546 views

Original Research

Published on 05 Aug 2026

Decoding the hypoxic injury landscape and hypoxic risk model construction in diabetic kidney disease: a multi-omics study

in Integrative Bioinformatics

Li Jiang
Chien Chieh
Haojun Zhang
Tingting Zhao
Xiai Wu

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1894439

373 views

Original Research

Accepted on 04 Aug 2026

Targeting IDH-Driven Oncometabolism in Glioblastoma: A Computational Approach for the Identification of Potential Inhibitors.

in Drug Discovery in Bioinformatics

Nivedhitha Tamilazhagan
Sivakumar Arumugam

Frontiers in Bioinformatics

819 articles

articles

IN SILICO AND IMMUNOINFORMATIC APPROACH TO DESIGN A MULTI-EPITOPE MRNA VACCINE TARGETING ALL MAJOR HUMAN-INFECTING GENOTYPES OF HEPATITIS E VIRUS

DZIP3 is associated with the cytoskeletal dynamics in glioblastoma and mitochondrial machinery regulation

Gene functions determine stochastic or adaptive futile transcription in cancers through deregulated start site deployments

PUDU (pipeline for universal diversity unveiling): an accessible end-to-end workflow for taxonomic profiling and ecological visualization of environmental microbiomes across amplicon, shotgun, and long-read sequencing

Correction: Transcriptome-informed metabolic modeling reveals astrocyte-specific vulnerabilities in mild cognitive impairment and Alzheimer’s disease progression

Design and in silico evaluation of Thiazole–Isoxazole hybrids as PPARγ-Targeted antidiabetic agents

Conformational Dynamics of Fuzzy Interfaces in Disordered Protein Complexes: Mapping Key Residues and Binding Modes Beyond NMR Models

Alternative Splicing Remodeling and Splicing Factor Regulatory Networks Define Immune-Associated Molecular Heterogeneity in Dilated Cardiomyopathy

Revealing RELL1 signaling relying on the phosphoregulatory network analysis

Integration of Resolving Topological Indices and ADMET Analysis with MCDM Methods (TOPSIS and SAW) for Ranking Breast Cancer Therapeutics

Ten Key Considerations for Developing Interpretable Risk Prediction Models

Multiple binding modes underlie Cannabis sativa cannabinoids recognition by peroxisome proliferator-activated receptor gamma

LungMicroHostR: an R package for integrated host–microbiome analysis of bronchoalveolar lavage fluid metagenomic sequencing data

All-atoms MD simulations study of newly designed ciprofloxacin derivatives as potential bacterial DHPS and DNA gyrase inhibitors

Establishing Standardized Evaluation Protocols for Peptide-Target Interaction Prediction: The PTI-TAPE Consensus Framework eDelphi

AI-enhanced virtual screening identifies a potent small-molecule modulator of ClC-3 for cervical cancer drug discovery

Integrated analysis of enzymes, mRNAs, and miRNAs provides insight into the regulatory potential of extracellular vesicles in recipient cell glucose metabolism

Evaluation of functional annotation-informed and ancestry-specific polygenic risk scores for ischemic stroke

REACH: A Reproducible Benchmark for Inter-Lineage Rare Malignant Cell Detection in Single Cell RNA Sequencing

Spatial transcriptomics reveal heterogeneous cell‒cell interactions among brain regions in cuprizone model consistent with multiple sclerosis lesions

Assessment of the Impact of Manual Curation in BioCyc

SiaRNA: a siamese neural network with bidirectional cross-attention for pairwise siRNA-mRNA efficacy prediction

Decoding the hypoxic injury landscape and hypoxic risk model construction in diabetic kidney disease: a multi-omics study

Targeting IDH-Driven Oncometabolism in Glioblastoma: A Computational Approach for the Identification of Potential Inhibitors.