Frontiers in Bioinformatics

Original Research

Published on 18 Aug 2026

Integrative network pharmacology and molecular modeling approaches reveal the therapeutic potential of Syzygium samarangense phytocompounds against diabetes retinopathy

in Drug Discovery in Bioinformatics

Arun Kandhan
Bijo Mathew
Sundarrajan Thirugnanasambandam

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1884743

326 views

Original Research

Accepted on 17 Aug 2026

A Single-Cell Atlas and Shiny-Based Framework for Murine Lung Injury and Remodeling

in Single Cell Bioinformatics

Qiuming Wang
Jixian Li
Philip J. Moos
Alessandro Venosa

Frontiers in Bioinformatics

Perspective

Accepted on 17 Aug 2026

Architectural Good Practices for Reproducible Benchmarking in Protein Machine Learning

in Integrative Bioinformatics

Julián García Vinuesa
Diego Fernández
Michelle Soto-García
Xavier Cadet
Mehdi D. Davari
Frederic Cadet
Juan A. Asenjo
Roberto Uribe-Paredes
David Alfredo Medina Ortiz

Frontiers in Bioinformatics

Original Research

Accepted on 17 Aug 2026

Computational Insights into Synergistic Mechanisms of PD-901 and 5-Azacitidine Targeting PTPN11 (SHP2) E76K Mutation in Juvenile Myelomonocytic Leukemia

in Protein Bioinformatics

Abeer M Al-Subaie
Balu Kamaraj

Frontiers in Bioinformatics

Original Research

Published on 14 Aug 2026

PLAC8 participates in the prognosis regulation of breast cancer by regulating the infiltration of immune cells in the tumor microenvironment

in RNA Bioinformatics

Mengqi Yu

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1814907

321 views

Original Research

Accepted on 13 Aug 2026

Comparative functional genomic analysis of table olive-associated Lactiplantibacillus plantarum strains

in Genomic Analysis

Elio López-García
Antonio Benítez Cabello
EFSTATHIOS Z. PANAGOU
José Luis Ruíz-Barba
Francisco Noé Arroyo López

Frontiers in Bioinformatics

191 views

Original Research

Published on 13 Aug 2026

RLNSF-MDA: reliability-guided graph-regularized matrix factorization for immune-related miRNA–disease association prediction

in RNA Bioinformatics

Xin Li
Yaoyu Liu
Ming Xu

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1926188

365 views

Perspective

Published on 12 Aug 2026

Agentic AI for trustworthy synthetic microbial genomics: a perspective on generation, validation, and governance

in Genomic Analysis

Fahim Sufi

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1903746

370 views

Original Research

Published on 12 Aug 2026

A microbe–drug association prediction model based on graph attention networks and rotation forest

in Drug Discovery in Bioinformatics

Jing Li
Juncai Li
Qijia Chen
Zhong Wang
Xianzhi Liu
Mingmin Liang
Junzhuang Wang
Hongyuan Ding
Bin Zeng
Lei Wang

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1871436

339 views

Original Research

Published on 12 Aug 2026

Single cell mapping of B and T cell dynamics in breast cancer lymph node metastasis

in Single Cell Bioinformatics

Sajid Khan
Sabahat Jamil
Muhammad Hamza
Zarlish Attique
Suping Zhang

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1833416

467 views

Technology and Code

Published on 12 Aug 2026

rMAP-Candida: a modular Dockerized WDL/Cromwell workflow for reproducible Candida species typing, assembly-contiguity assessment, antifungal-resistance marker screening, and phylogenomic surveillance

in Genomic Analysis

Gerald Mboowa
Ivan Sserwadda
Stephen Kanyerezi
Benson R. Kidenya
Jonani Bwambale
Benson Musinguzi

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1896572

447 views

Brief Research Report

Published on 12 Aug 2026

Detecting poliovirus sequences in the sequence read archive database using bioinformatics tools

in Genomic Analysis

Katie Farrell
Kevin Tang
Melchizedek Mashiku
Dawit Abay
Joseph Longo
Edward Ramos
Gabriel Leventhal-Douglas
Margaret Rohrbaugh
Paul Chenoweth
Cara C. Burns

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1856011

362 views

Original Research

Accepted on 11 Aug 2026

IN SILICO AND IMMUNOINFORMATIC APPROACH TO DESIGN A MULTI-EPITOPE MRNA VACCINE TARGETING ALL MAJOR HUMAN-INFECTING GENOTYPES OF HEPATITIS E VIRUS

in Drug Discovery in Bioinformatics

Maham Mehrangaze Khonza
Zain Saeed
Zohra Jabeen
Wafaa Arab
Sehrish Kakakhel
Maham Yamin
MAZEN GHAITH
Ali Zohaib
Aneela Javed
Rwaa H. Abdulal

Frontiers in Bioinformatics

238 views

Original Research

Accepted on 11 Aug 2026

DZIP3 is associated with the cytoskeletal dynamics in glioblastoma and mitochondrial machinery regulation

in Protein Bioinformatics

Khadija Bichri
Meryeme Chihab Eddine
Mohammed Sqalli Houssaini
Mounir Rghioui
Imad El Badisy
Bouchra GHAZI

Frontiers in Bioinformatics

207 views

Original Research

Accepted on 11 Aug 2026

Gene functions determine stochastic or adaptive futile transcription in cancers through deregulated start site deployments

in Integrative Bioinformatics

Aditi Lakshmi Satish
Praveen Kumar
Ishani Morbia
Umashankar Singh

Frontiers in Bioinformatics

185 views

Technology and Code

Published on 11 Aug 2026

PUDU (pipeline for universal diversity unveiling): an accessible end-to-end workflow for taxonomic profiling and ecological visualization of environmental microbiomes across amplicon, shotgun, and long-read sequencing

in Integrative Bioinformatics

Alejandro Medaglia-Mata
Pablo Rojas-Rodríguez
Vojtěch Bystrý
Rossy Guillén-Watson
Olman Gómez-Espinoza
Kattia Núñez-Montero

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1909327

393 views

Correction

Published on 11 Aug 2026

Correction: Transcriptome-informed metabolic modeling reveals astrocyte-specific vulnerabilities in mild cognitive impairment and Alzheimer’s disease progression

in Integrative Bioinformatics

Andrea Angarita-Rodríguez
Viviana Vargas-López
Andrés Pinzón
Adrián Sandoval-Hernandez
Kai Kang
Leping Li
Jason Papin
Pedro Puentes-Rozo
Andrés Felipe Aristizábal
Janneth González

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1953979

199 views

Original Research

Published on 11 Aug 2026

Design and in silico evaluation of Thiazole–Isoxazole hybrids as PPARγ-Targeted antidiabetic agents

in Drug Discovery in Bioinformatics

Abhirami PV
Gupta Dheeraj Rajesh
N. V. L. Sirisha Mulukuri
Ranjitha A
Niyas Rehman
Shiv Basant Kumar
Dileep Kumar
Pankaj Kumar

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1873262

575 views

Original Research

Accepted on 10 Aug 2026

Conformational Dynamics of Fuzzy Interfaces in Disordered Protein Complexes: Mapping Key Residues and Binding Modes Beyond NMR Models

in Protein Bioinformatics

María Laura Fernández
María Clara Bastien
Franco G. Tavolaro
Cristina Marino-Buslje

Frontiers in Bioinformatics

258 views

Original Research

Accepted on 10 Aug 2026

Alternative Splicing Remodeling and Splicing Factor Regulatory Networks Define Immune-Associated Molecular Heterogeneity in Dilated Cardiomyopathy

in Integrative Bioinformatics

Jia Li
Yiyu He
Xianxian Zhao
Zhifu Guo
Jinchao Song
Xiaowei Song

Frontiers in Bioinformatics

206 views

Original Research

Accepted on 10 Aug 2026

Revealing RELL1 signaling relying on the phosphoregulatory network analysis

in Protein Bioinformatics

Pathiyil Sajini Sekhar
DIYA SANJEEV
Amal Fahma
Suhail Subair
Athira Perunelly Gopalakrishnan
PRATHIK B S
Rajesh Raju
Sowmya Soman

Frontiers in Bioinformatics

188 views

Original Research

Accepted on 10 Aug 2026

Integration of Resolving Topological Indices and ADMET Analysis with MCDM Methods (TOPSIS and SAW) for Ranking Breast Cancer Therapeutics

in Drug Discovery in Bioinformatics

Pandeeswari E
Ravi Sankar J

Frontiers in Bioinformatics

205 views

Opinion

Accepted on 10 Aug 2026

Ten Key Considerations for Developing Interpretable Risk Prediction Models

in Integrative Bioinformatics

Xi Zhang
Wenjie Xu
David Roy Smith

Frontiers in Bioinformatics

208 views

Original Research

Published on 10 Aug 2026

Multiple binding modes underlie Cannabis sativa cannabinoids recognition by peroxisome proliferator-activated receptor gamma

in Drug Discovery in Bioinformatics

N. R. Carina Alves
Justina Miranda
Lautaro D. Alvarez

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1893303

420 views

822 articles

articles

Integrative network pharmacology and molecular modeling approaches reveal the therapeutic potential of Syzygium samarangense phytocompounds against diabetes retinopathy

A Single-Cell Atlas and Shiny-Based Framework for Murine Lung Injury and Remodeling

Architectural Good Practices for Reproducible Benchmarking in Protein Machine Learning

Computational Insights into Synergistic Mechanisms of PD-901 and 5-Azacitidine Targeting PTPN11 (SHP2) E76K Mutation in Juvenile Myelomonocytic Leukemia

PLAC8 participates in the prognosis regulation of breast cancer by regulating the infiltration of immune cells in the tumor microenvironment

Comparative functional genomic analysis of table olive-associated Lactiplantibacillus plantarum strains

RLNSF-MDA: reliability-guided graph-regularized matrix factorization for immune-related miRNA–disease association prediction

Agentic AI for trustworthy synthetic microbial genomics: a perspective on generation, validation, and governance

A microbe–drug association prediction model based on graph attention networks and rotation forest

Single cell mapping of B and T cell dynamics in breast cancer lymph node metastasis

rMAP-Candida: a modular Dockerized WDL/Cromwell workflow for reproducible Candida species typing, assembly-contiguity assessment, antifungal-resistance marker screening, and phylogenomic surveillance

Detecting poliovirus sequences in the sequence read archive database using bioinformatics tools

IN SILICO AND IMMUNOINFORMATIC APPROACH TO DESIGN A MULTI-EPITOPE MRNA VACCINE TARGETING ALL MAJOR HUMAN-INFECTING GENOTYPES OF HEPATITIS E VIRUS

DZIP3 is associated with the cytoskeletal dynamics in glioblastoma and mitochondrial machinery regulation

Gene functions determine stochastic or adaptive futile transcription in cancers through deregulated start site deployments

PUDU (pipeline for universal diversity unveiling): an accessible end-to-end workflow for taxonomic profiling and ecological visualization of environmental microbiomes across amplicon, shotgun, and long-read sequencing

Correction: Transcriptome-informed metabolic modeling reveals astrocyte-specific vulnerabilities in mild cognitive impairment and Alzheimer’s disease progression

Design and in silico evaluation of Thiazole–Isoxazole hybrids as PPARγ-Targeted antidiabetic agents

Conformational Dynamics of Fuzzy Interfaces in Disordered Protein Complexes: Mapping Key Residues and Binding Modes Beyond NMR Models

Alternative Splicing Remodeling and Splicing Factor Regulatory Networks Define Immune-Associated Molecular Heterogeneity in Dilated Cardiomyopathy

Revealing RELL1 signaling relying on the phosphoregulatory network analysis

Integration of Resolving Topological Indices and ADMET Analysis with MCDM Methods (TOPSIS and SAW) for Ranking Breast Cancer Therapeutics

Ten Key Considerations for Developing Interpretable Risk Prediction Models

Multiple binding modes underlie Cannabis sativa cannabinoids recognition by peroxisome proliferator-activated receptor gamma