Frontiers in Bioinformatics

Original Research

Published on 10 Aug 2026

Multiple binding modes underlie Cannabis sativa cannabinoids recognition by peroxisome proliferator-activated receptor gamma

in Drug Discovery in Bioinformatics

N. R. Carina Alves
Justina Miranda
Lautaro D. Alvarez

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1893303

247 views

Original Research

Published on 10 Aug 2026

LungMicroHostR: an R package for integrated host–microbiome analysis of bronchoalveolar lavage fluid metagenomic sequencing data

in Integrative Bioinformatics

Nan Li
Jing Hu
Wanning Tong
Chengdong Liu
Yun Ding
Ning Li
Zhigang Cai

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1906036

223 views

Original Research

Accepted on 07 Aug 2026

All-atoms MD simulations study of newly designed ciprofloxacin derivatives as potential bacterial DHPS and DNA gyrase inhibitors

in Drug Discovery in Bioinformatics

Chita Ranjan Sahoo
Madhusmita Rout
SUDHIR KUMAR PAIDESETTY
Dr. Budheswar Dehury
DEBDUTTA BHATTACHARYA
Sanghamitra Pati

Frontiers in Bioinformatics

Original Research

Accepted on 07 Aug 2026

Establishing Standardized Evaluation Protocols for Peptide-Target Interaction Prediction: The PTI-TAPE Consensus Framework eDelphi

in Protein Bioinformatics

William Waldock
Guangshun Wang
Ara Darzi
Cesar de la Fuente-Nunez
Hutan Ashrafian

Frontiers in Bioinformatics

Original Research

Published on 07 Aug 2026

AI-enhanced virtual screening identifies a potent small-molecule modulator of ClC-3 for cervical cancer drug discovery

in Drug Discovery in Bioinformatics

Chao Liu
Chongxing Ji

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1887419

350 views

Original Research

Published on 07 Aug 2026

Integrated analysis of enzymes, mRNAs, and miRNAs provides insight into the regulatory potential of extracellular vesicles in recipient cell glucose metabolism

in Integrative Bioinformatics

Namita N. Kashyap
Sharath Mohan Bhat
Padmanabha Udupa E. G.
Kavitha S. Shettigar
Vinutha R. Bhat
Dinesh Upadhya

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1911554

395 views

Original Research

Accepted on 06 Aug 2026

Evaluation of functional annotation-informed and ancestry-specific polygenic risk scores for ischemic stroke

in Genomic Analysis

Nicole D. Armstrong
Vinodh Srinivasasainagendra
Amit Patki
Lavanya Pilla
Chad Aldridge
Alana Jones
Ulrich Broeckel
Ethan M. Lange
Leslie A. Lange
Pankaj Arora

Frontiers in Bioinformatics

Original Research

Accepted on 06 Aug 2026

REACH: A Reproducible Benchmark for Inter-Lineage Rare Malignant Cell Detection in Single Cell RNA Sequencing

in Integrative Bioinformatics

Moram Venkata Satya Jaswanth
Amruthaluri Gavin
Padarthi Aakash
Muttha Tejesh Kumar
Abhijit Dasgupta

Frontiers in Bioinformatics

Original Research

Published on 06 Aug 2026

Spatial transcriptomics reveal heterogeneous cell‒cell interactions among brain regions in cuprizone model consistent with multiple sclerosis lesions

in Single Cell Bioinformatics

Hui-Hsin Tsai
Sarbottam Piya
Jing Wang
Jing Zhu
Wenxing Hu
Andrew R. Gehrke
Shaolong Cao
Amanda J. Guise
Su Jing Chan
Mark Sheehan

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1832826

558 views

Original Research

Accepted on 05 Aug 2026

Assessment of the Impact of Manual Curation in BioCyc

in Genomic Analysis

Ron Caspi
Brendan Wilson-Mortier
Lisa R Moore
Dylan Beesley
Ian T Paulsen
Peter D Karp

Frontiers in Bioinformatics

Original Research

Published on 05 Aug 2026

SiaRNA: a siamese neural network with bidirectional cross-attention for pairwise siRNA-mRNA efficacy prediction

in Drug Discovery in Bioinformatics

Vaishnavi Sapireddy
Rajkumar Nathi
Venkata Harshit Meruva
Varun Raju Nannapuraju
Bhargava Chary Basangari
Vani Kondaparthi

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1827877

522 views

Original Research

Published on 05 Aug 2026

Decoding the hypoxic injury landscape and hypoxic risk model construction in diabetic kidney disease: a multi-omics study

in Integrative Bioinformatics

Li Jiang
Chien Chieh
Haojun Zhang
Tingting Zhao
Xiai Wu

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1894439

348 views

Correction

Accepted on 04 Aug 2026

Correction: Transcriptome-informed metabolic modeling reveals astrocyte-specific vulnerabilities in mild cognitive impairment and Alzheimer's disease progression

in Integrative Bioinformatics

Andrea Angarita-Rodríguez

Frontiers in Bioinformatics

Original Research

Accepted on 04 Aug 2026

Targeting IDH-Driven Oncometabolism in Glioblastoma: A Computational Approach for the Identification of Potential Inhibitors.

in Drug Discovery in Bioinformatics

Nivedhitha Tamilazhagan
Sivakumar Arumugam

Frontiers in Bioinformatics

Original Research

Published on 04 Aug 2026

MultiCausGRN: directed prior-guided graph attention model for multi-omics gene regulatory network inference

in Network Bioinformatics

Noor Jamal Alkhateeb
Mamoun Awad

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1883130

584 views

Review

Accepted on 03 Aug 2026

Molecular Biology and Integrated Strategies for Activating Cryptic Biosynthetic Gene Clusters toward Next-Generation Antibiotic Discovery

in Drug Discovery in Bioinformatics

Dr. Veilumuthu Pattapulavar
Sathiyabama Ramanujam
Avanthi Yellampalli
Henu Sree Badiginchala
Godwin Christopher John

Frontiers in Bioinformatics

105 views

Review

Accepted on 03 Aug 2026

The Impact of Deep Learning and Omics Data in Transforming Precision Therapy for Brain Cancer

in Integrative Bioinformatics

Sana Munquad
Anam Upadhyay
Asim Bikas Das

Frontiers in Bioinformatics

149 views

Original Research

Accepted on 03 Aug 2026

TNRSim — a simulator of truncated Oxford Nanopore direct RNA long reads for isoform analysis

in RNA Bioinformatics

Anna Kozlova
Artemiy Sakharov
Ekaterina Viktorovna Ilgisonis
Elena Ponomarenko

Frontiers in Bioinformatics

111 views

Original Research

Accepted on 31 Jul 2026

Neuro-Psycho MMSig: Multimodal mechanism enrichment platform for neuropsychiatric disorders

in Integrative Bioinformatics

Vinay Bharadhwaj
Karim Shalaby
Sathvik Guru Rao
Bruce Schultz
Jiayuan Zhang
Daniel Domingo-Fernández
Martin Hofmann-Apitius
Alpha Tom Kodamullil

Frontiers in Bioinformatics

190 views

Original Research

Published on 31 Jul 2026

Molecular docking and dynamics simulation studies uncover the host–pathogen protein–protein interactions in soybean (Glycine max (L.) Merr.) and Groundnut bud necrosis virus: first report

in Drug Discovery in Bioinformatics

Rayees Ahmad Bhat
Ayyagari Ramlal
Amooru Harika
Ashutosh Sharma
Ambika Rajendran
Iten M. Fawzy
Sreeramanan Subramaniam
Dhandapani Raju
S. K. Lal
Sonu Krishankumar

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1821527

955 views

Original Research

Published on 31 Jul 2026

LNMGAT: a laplacian regularized pseudo-negative mining graph attention network for robust drug–target interaction prediction under multi-scenario cold-start settings

in Drug Discovery in Bioinformatics

Shuai Guo
Weichi Liu
Jie Zou
Tao Ban
Gaifang Dong

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1882476

493 views

Original Research

Accepted on 30 Jul 2026

Sesamum indicum-Derived Valdiate as a Novel Neuroprotective Agent Targeting PDE10A2 and SIRT1 in Huntington's Disease

in Drug Discovery in Bioinformatics

Mukul Shyam
MD Wafi Ismail
Deepak Sharma
Prathap Srirangan
Rajiniraja Muniyan
Sabina Evan Prince

Frontiers in Bioinformatics

184 views

Original Research

Accepted on 29 Jul 2026

Systematic evaluation of spatial transcriptomic annotation methods reveals conserved tumor microenvironment programs in NSCLC

in Single Cell Bioinformatics

Mingke Wu
Yihan Zhou
Dingjie Xu

Frontiers in Bioinformatics

229 views

Perspective

Accepted on 29 Jul 2026

Agentic AI for Trustworthy Synthetic Microbial Genomics: A Perspective on Generation, Validation, and Governance

in Genomic Analysis

Fahim Sufi

Frontiers in Bioinformatics

185 views

811 articles

articles

Multiple binding modes underlie Cannabis sativa cannabinoids recognition by peroxisome proliferator-activated receptor gamma

LungMicroHostR: an R package for integrated host–microbiome analysis of bronchoalveolar lavage fluid metagenomic sequencing data

All-atoms MD simulations study of newly designed ciprofloxacin derivatives as potential bacterial DHPS and DNA gyrase inhibitors

Establishing Standardized Evaluation Protocols for Peptide-Target Interaction Prediction: The PTI-TAPE Consensus Framework eDelphi

AI-enhanced virtual screening identifies a potent small-molecule modulator of ClC-3 for cervical cancer drug discovery

Integrated analysis of enzymes, mRNAs, and miRNAs provides insight into the regulatory potential of extracellular vesicles in recipient cell glucose metabolism

Evaluation of functional annotation-informed and ancestry-specific polygenic risk scores for ischemic stroke

REACH: A Reproducible Benchmark for Inter-Lineage Rare Malignant Cell Detection in Single Cell RNA Sequencing

Spatial transcriptomics reveal heterogeneous cell‒cell interactions among brain regions in cuprizone model consistent with multiple sclerosis lesions

Assessment of the Impact of Manual Curation in BioCyc

SiaRNA: a siamese neural network with bidirectional cross-attention for pairwise siRNA-mRNA efficacy prediction

Decoding the hypoxic injury landscape and hypoxic risk model construction in diabetic kidney disease: a multi-omics study

Correction: Transcriptome-informed metabolic modeling reveals astrocyte-specific vulnerabilities in mild cognitive impairment and Alzheimer's disease progression

Targeting IDH-Driven Oncometabolism in Glioblastoma: A Computational Approach for the Identification of Potential Inhibitors.

MultiCausGRN: directed prior-guided graph attention model for multi-omics gene regulatory network inference

Molecular Biology and Integrated Strategies for Activating Cryptic Biosynthetic Gene Clusters toward Next-Generation Antibiotic Discovery

The Impact of Deep Learning and Omics Data in Transforming Precision Therapy for Brain Cancer

TNRSim — a simulator of truncated Oxford Nanopore direct RNA long reads for isoform analysis

Neuro-Psycho MMSig: Multimodal mechanism enrichment platform for neuropsychiatric disorders

Molecular docking and dynamics simulation studies uncover the host–pathogen protein–protein interactions in soybean (Glycine max (L.) Merr.) and Groundnut bud necrosis virus: first report

LNMGAT: a laplacian regularized pseudo-negative mining graph attention network for robust drug–target interaction prediction under multi-scenario cold-start settings

Sesamum indicum-Derived Valdiate as a Novel Neuroprotective Agent Targeting PDE10A2 and SIRT1 in Huntington's Disease

Systematic evaluation of spatial transcriptomic annotation methods reveals conserved tumor microenvironment programs in NSCLC

Agentic AI for Trustworthy Synthetic Microbial Genomics: A Perspective on Generation, Validation, and Governance