Frontiers in Bioinformatics

Original Research

Accepted on 10 Sep 2025

Computational drug repurposing reveals Alectinib as a potential lead targeting Cathepsin S for therapeutic developments against cancer and chronic pain

in Drug Discovery in Bioinformatics

Mohammed Alrouji
Mohammed S Alshammari
Sharif Alhajlah
Syed Tasqeeruddin
Dinislam Khuzin
Anas Shamsi
Saleha Anwar

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1666573

123 views

Original Research

Published on 10 Sep 2025

Single-cell splicing QTL analysis in pancreatic islets

in Genomic Analysis

Jae-Won Cho
Jingyi Cao
Martin Hemberg

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1657895

179 views

Technology and Code

Published on 08 Sep 2025

PharmacoForge: pharmacophore generation with diffusion models

in Drug Discovery in Bioinformatics

Emma L. Flynn
Riya Shah
Ian Dunn
Rishal Aggarwal
David Ryan Koes

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1628800

549 views

FAIR² Data

Published on 08 Sep 2025

Structure-based prediction of SARS-CoV-2 variant properties using machine learning on mutational neighborhoods

in Integrative Bioinformatics

Max van den Boom
Erik Schultes
Thomas Hankemeier

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1634111

1,193 views

Technology and Code

Published on 05 Sep 2025

TCRscape: a single-cell multi-omic TCR profiling toolkit

in Single Cell Bioinformatics

Roman Perik-Zavodskii
Olga Perik-Zavodskaia
Marina Volynets
Saleh Alrhmoun
Sergey Sennikov

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1641491

771 views

Technology and Code

Published on 05 Sep 2025

An image analysis pipeline to quantify the spatial distribution of cell markers in stroma-rich tumors

in Computational BioImaging

Antoine A. Ruzette
Nina Kozlova
Kayla A. Cruz
Taru Muranen
Simon F. Nørrelykke

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1619790

480 views

Original Research

Accepted on 04 Sep 2025

Interpretable Artificial Intelligence Based on Immunoregulation-Related Genes Predicts Prognosis and Immunotherapy Response in Lung Adenocarcinoma

in Genomic Analysis

Minghao Wang
Yu Wang
Yitong Li
Chengyi Zhang
Canjun Li
Nan Bi

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1613761

409 views

Methods

Published on 04 Sep 2025

A novel linear indexing method for strings under all internal nodes in a suffix tree

in Integrative Bioinformatics

Anas Al-okaily
Abdelghani Tbakhi

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1577324

498 views

Brief Research Report

Published on 04 Sep 2025

Adaptive sampling methods facilitate the determination of reliable dataset sizes for evidence-based modeling

in Data Visualization

Tim Breitenbach
Thomas Dandekar

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1528515

624 views

Technology and Code

Published on 04 Sep 2025

Protein cleaver: an interactive web interface for in silico prediction and systematic annotation of protein digestion-derived peptides

in Protein Bioinformatics

Grigorios Koulouras
Yingrong Xu

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1576317

1,065 views

Editorial

Published on 02 Sep 2025

Editorial: Networks and graphs in biological data: current methods, opportunities and challenges

in Network Bioinformatics

Derek L. Thompson
Hsiang-Yun Wu
Christopher W. Bartlett
William C. Ray

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1685992

543 views

Data Report

Published on 02 Sep 2025

Germline mutation profiling of breast cancer patients using a non-BRCA sequencing panel

in Genomic Analysis

Sonar Soni Panigoro
Rafika Indah Paramita
Fadilah Fadilah
Septelia Inawati Wanandi
Aisyah Fitriannisa Prawiningrum
Linda Erlina
Wahyu Dian Utari
Ajeng Megawati Fajrin

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1620025

719 views

Original Research

Accepted on 01 Sep 2025

Integrative Machine Learning and Transcriptomic Analysis Identifies Key Molecular Targets in MNPN-Associated Oral Squamous Cell Carcinoma Pathogenesis

in Network Bioinformatics

Xiangjun Wang
Panpan Jin
Juan Xu
Junyi Li
Mengzhen Ji

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1664576

320 views

Original Research

Accepted on 01 Sep 2025

Key Genes Associated with Brain Metastasis in Non-Small Cell Lung Cancer: Novel Insights from Bioinformatics Analysis

in Integrative Bioinformatics

Shuang Zhao
He Zhang

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1625664

225 views

Original Research

Published on 01 Sep 2025

COCαDA - a fast and scalable algorithm for interatomic contact detection in proteins using Cα distance matrices

in Protein Bioinformatics

Rafael Pereira Lemos
Diego Mariano
Sabrina De Azevedo Silveira
Raquel C. de Melo-Minardi

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1630078

537 views

Original Research

Accepted on 29 Aug 2025

Discovering Biomarkers for Chronic Sinusitis with Nasal Polyps: A Study Integrating Bioinformatics Analysis and Experimental Validation of Macrophage Polarization and Metabolism-Related Genes

in Network Bioinformatics

Juan Zhou
Huan Wang
Jin Wang
Fuming Zhou

Frontiers in Bioinformatics

doi 10.3389/fbinf.2025.1613136

221 views