Frontiers in Bioinformatics

Original Research

Published on 20 Aug 2026

Systematic evaluation of spatial transcriptomic annotation methods reveals conserved tumor microenvironment programs in NSCLC

in Single Cell Bioinformatics

Mingke Wu
Yihan Zhou
Dingjie Xu

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1880333

336 views

Original Research

Published on 20 Aug 2026

Quantifying pathway perturbations based on gene network rewiring in sepsis progression toward death or survival

in Network Bioinformatics

Dimitra Kiakou
Margarita Zachariou
Marilena M. Bourdakou
Theodoros Kyprianou
George M. Spyrou

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1890081

259 views

Original Research

Published on 20 Aug 2026

Network-based integrative analysis of multi-level regulatory mechanisms associated with glyphosate exposure

in Network Bioinformatics

Claudia Consuegra-Mayor
Barbara Arroyo-Salgado
Jesus Olivero-Verbel

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1890219

273 views

Original Research

Published on 20 Aug 2026

Computational blueprint and stereochemical validation of a small peptide derived from Lacticaseibacillus casei VITCM05 targeting estrogen receptor alpha and human epidermal growth factor receptor 2

in Protein Bioinformatics

G. R. Shree Kumari
Mohanasrinivasan Vaithilingam

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1918460

248 views

Review

Published on 19 Aug 2026

Human ancestries simulation and inference: a review of ancestral recombination graph-based approaches

in Evolutionary Bioinformatics

Patrick Fournier
Fabrice Larribe

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1878981

371 views

Methods

Published on 19 Aug 2026

A practical guide to functional enrichment analysis

in Protein Bioinformatics

Fábio Henrique Schuster de Oliveira
Lucas Giron dos Santos
Bruno César Feltes

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1895224

321 views

Original Research

Published on 19 Aug 2026

Benchmarking computational decontamination of ambient RNA

in Single Cell Bioinformatics

Cecilie Bøgh Cargnelli
Jakob Vennike Nielsen
Jesper Grud Skat Madsen

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1844838

614 views

Original Research

Accepted on 18 Aug 2026

Identifying mounting behaviour in boars using deep learning-based instance segmentation and binary classification – a pilot study

in Computational BioImaging

Harry Aricibasi
Jessica Bode
Renée Bergeron
Dan Tulpan

Frontiers in Bioinformatics

418 views

Original Research

Published on 18 Aug 2026

A recurrently perturbed 12-gene program marks drug-tolerant persister states across cancer types

in Integrative Bioinformatics

Itika Arora
Ahmed Mohammed Adam
Abdullah O. Aljaylani
Jumana Z. Alzuhayri
Ehab M. M. Ali
Faisal A. Alzahrani
Mohammad Imran Khan
Ahmed Yaqinuddin

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1882238

658 views

Original Research

Published on 18 Aug 2026

Integrative network pharmacology and molecular modeling approaches reveal the therapeutic potential of Syzygium samarangense phytocompounds against diabetes retinopathy

in Drug Discovery in Bioinformatics

Arun Kandhan
Bijo Mathew
Sundarrajan Thirugnanasambandam

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1884743

396 views

Original Research

Published on 18 Aug 2026

Genomic exploration and in silico prioritization of putative COX-2-targeting metabolites from Streptomyces sp. VITGV156 (MCC 4965)

in Drug Discovery in Bioinformatics

Veilumuthu Pattapulavar
Saranyadevi Subburaj
Sathiyabama Ramanujam
Priyadharshini Suresh Babu
Krishna Santhoshkumar
Anitha Kandasamy
Ramasamy Tamizhselvi
Divya Sharma
John Godwin Christopher

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1840680

500 views

Original Research

Accepted on 17 Aug 2026

A Single-Cell Atlas and Shiny-Based Framework for Murine Lung Injury and Remodeling

in Single Cell Bioinformatics

Qiuming Wang
Jixian Li
Philip J. Moos
Alessandro Venosa

Frontiers in Bioinformatics

Perspective

Accepted on 17 Aug 2026

Architectural Good Practices for Reproducible Benchmarking in Protein Machine Learning

in Integrative Bioinformatics

Julián García Vinuesa
Diego Fernández
Michelle Soto-García
Xavier Cadet
Mehdi D. Davari
Frederic Cadet
Juan A. Asenjo
Roberto Uribe-Paredes
David Alfredo Medina Ortiz

Frontiers in Bioinformatics

Original Research

Accepted on 17 Aug 2026

Computational Insights into Synergistic Mechanisms of PD-901 and 5-Azacitidine Targeting PTPN11 (SHP2) E76K Mutation in Juvenile Myelomonocytic Leukemia

in Protein Bioinformatics

Abeer M Al-Subaie
Balu Kamaraj

Frontiers in Bioinformatics

Original Research

Published on 14 Aug 2026

PLAC8 participates in the prognosis regulation of breast cancer by regulating the infiltration of immune cells in the tumor microenvironment

in RNA Bioinformatics

Mengqi Yu

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1814907

354 views

Original Research

Accepted on 13 Aug 2026

Comparative functional genomic analysis of table olive-associated Lactiplantibacillus plantarum strains

in Genomic Analysis

Elio López-García
Antonio Benítez Cabello
EFSTATHIOS Z. PANAGOU
José Luis Ruíz-Barba
Francisco Noé Arroyo López

Frontiers in Bioinformatics

210 views

Original Research

Published on 13 Aug 2026

RLNSF-MDA: reliability-guided graph-regularized matrix factorization for immune-related miRNA–disease association prediction

in RNA Bioinformatics

Xin Li
Yaoyu Liu
Ming Xu

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1926188

399 views

Original Research

Published on 12 Aug 2026

A microbe–drug association prediction model based on graph attention networks and rotation forest

in Drug Discovery in Bioinformatics

Jing Li
Juncai Li
Qijia Chen
Zhong Wang
Xianzhi Liu
Mingmin Liang
Junzhuang Wang
Hongyuan Ding
Bin Zeng
Lei Wang

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1871436

354 views

Perspective

Published on 12 Aug 2026

Agentic AI for trustworthy synthetic microbial genomics: a perspective on generation, validation, and governance

in Genomic Analysis

Fahim Sufi

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1903746

413 views

Original Research

Published on 12 Aug 2026

Single cell mapping of B and T cell dynamics in breast cancer lymph node metastasis

in Single Cell Bioinformatics

Sajid Khan
Sabahat Jamil
Muhammad Hamza
Zarlish Attique
Suping Zhang

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1833416

541 views

Technology and Code

Published on 12 Aug 2026

rMAP-Candida: a modular Dockerized WDL/Cromwell workflow for reproducible Candida species typing, assembly-contiguity assessment, antifungal-resistance marker screening, and phylogenomic surveillance

in Genomic Analysis

Gerald Mboowa
Ivan Sserwadda
Stephen Kanyerezi
Benson R. Kidenya
Jonani Bwambale
Benson Musinguzi

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1896572

460 views

Brief Research Report

Published on 12 Aug 2026

Detecting poliovirus sequences in the sequence read archive database using bioinformatics tools

in Genomic Analysis

Katie Farrell
Kevin Tang
Melchizedek Mashiku
Dawit Abay
Joseph Longo
Edward Ramos
Gabriel Leventhal-Douglas
Margaret Rohrbaugh
Paul Chenoweth
Cara C. Burns

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1856011

378 views

Original Research

Accepted on 11 Aug 2026

IN SILICO AND IMMUNOINFORMATIC APPROACH TO DESIGN A MULTI-EPITOPE MRNA VACCINE TARGETING ALL MAJOR HUMAN-INFECTING GENOTYPES OF HEPATITIS E VIRUS

in Drug Discovery in Bioinformatics

Maham Mehrangaze Khonza
Zain Saeed
Zohra Jabeen
Wafaa Arab
Sehrish Kakakhel
Maham Yamin
MAZEN GHAITH
Ali Zohaib
Aneela Javed
Rwaa H. Abdulal

Frontiers in Bioinformatics

263 views

Original Research

Accepted on 11 Aug 2026

DZIP3 is associated with the cytoskeletal dynamics in glioblastoma and mitochondrial machinery regulation

in Protein Bioinformatics

Khadija Bichri
Meryeme Chihab Eddine
Mohammed Sqalli Houssaini
Mounir Rghioui
Imad El Badisy
Bouchra GHAZI

Frontiers in Bioinformatics

240 views

822 articles

articles

Systematic evaluation of spatial transcriptomic annotation methods reveals conserved tumor microenvironment programs in NSCLC

Quantifying pathway perturbations based on gene network rewiring in sepsis progression toward death or survival

Network-based integrative analysis of multi-level regulatory mechanisms associated with glyphosate exposure

Computational blueprint and stereochemical validation of a small peptide derived from Lacticaseibacillus casei VITCM05 targeting estrogen receptor alpha and human epidermal growth factor receptor 2

Human ancestries simulation and inference: a review of ancestral recombination graph-based approaches

A practical guide to functional enrichment analysis

Benchmarking computational decontamination of ambient RNA

Identifying mounting behaviour in boars using deep learning-based instance segmentation and binary classification – a pilot study

A recurrently perturbed 12-gene program marks drug-tolerant persister states across cancer types

Integrative network pharmacology and molecular modeling approaches reveal the therapeutic potential of Syzygium samarangense phytocompounds against diabetes retinopathy

Genomic exploration and in silico prioritization of putative COX-2-targeting metabolites from Streptomyces sp. VITGV156 (MCC 4965)

A Single-Cell Atlas and Shiny-Based Framework for Murine Lung Injury and Remodeling

Architectural Good Practices for Reproducible Benchmarking in Protein Machine Learning

Computational Insights into Synergistic Mechanisms of PD-901 and 5-Azacitidine Targeting PTPN11 (SHP2) E76K Mutation in Juvenile Myelomonocytic Leukemia

PLAC8 participates in the prognosis regulation of breast cancer by regulating the infiltration of immune cells in the tumor microenvironment

Comparative functional genomic analysis of table olive-associated Lactiplantibacillus plantarum strains

RLNSF-MDA: reliability-guided graph-regularized matrix factorization for immune-related miRNA–disease association prediction

A microbe–drug association prediction model based on graph attention networks and rotation forest

Agentic AI for trustworthy synthetic microbial genomics: a perspective on generation, validation, and governance

Single cell mapping of B and T cell dynamics in breast cancer lymph node metastasis

rMAP-Candida: a modular Dockerized WDL/Cromwell workflow for reproducible Candida species typing, assembly-contiguity assessment, antifungal-resistance marker screening, and phylogenomic surveillance

Detecting poliovirus sequences in the sequence read archive database using bioinformatics tools

IN SILICO AND IMMUNOINFORMATIC APPROACH TO DESIGN A MULTI-EPITOPE MRNA VACCINE TARGETING ALL MAJOR HUMAN-INFECTING GENOTYPES OF HEPATITIS E VIRUS

DZIP3 is associated with the cytoskeletal dynamics in glioblastoma and mitochondrial machinery regulation