Frontiers in Bioinformatics

Original Research

Published on 14 Apr 2026

Self-organizing maps for allele specific expression data reconstruction and identification of anomalous genomic regions

in Integrative Bioinformatics

Roberto Pagliarini
Francesco Nascimben
Alberto Policriti

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1810835

Methods

Published on 14 Apr 2026

Resolving heterogeneity in Lymph Node Stromal Cells using high-dimensional analysis of non-optimized flow cytometry data

in Computational BioImaging

Mikala E. Heon
Eduardo Rosa-Molinar

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1657030

Original Research

Accepted on 13 Apr 2026

Transcriptomics-Guided Discovery of Interleukin-6 Modulators from Bacillus subtilis Metabolites in Type 2 Diabetes Mellitus

in Drug Discovery in Bioinformatics

Tarsha S M
Sidharth Kumar N
Vasundra Vasudevan
Madhana Priya N
Dr Thirumal Kumar D
Amudha G
Magesh Ramasamy

Frontiers in Bioinformatics

Original Research

Accepted on 13 Apr 2026

Predicting Anthropometric Body Composition Variables Using 3D Optical Imaging and Machine Learning

in Integrative Bioinformatics

Gyaneshwar Agrahari
Kiran Bist
Monika Pandey
Jacob Kapita
Zachary James
Jackson Knox
Steven Heymsfield
Sophia Ramirez
Peter Wolenski
Nadejda Drenska

Frontiers in Bioinformatics

Original Research

Accepted on 13 Apr 2026

BlinkFusion: Modular platform quantifying labeling efficiency and photophysics in regular and super-resolution fluorescence microscopy

in Computational BioImaging

Alejandro Salgado
Nada Naguib
Ulrich Wiesner
Alba Avila

Frontiers in Bioinformatics

Correction

Accepted on 13 Apr 2026

Corrigendum: An integrated automated deep learning framework for annotating tumor-infiltrating lymphocytes in lung adenocarcinoma pathology

in Integrative Bioinformatics

Xia Li
Kang-Lai Wei
Zhao-Quan Huang
Zi-Yan Huang

Frontiers in Bioinformatics

Methods

Accepted on 13 Apr 2026

Licorice-derived prenylated chalcones alleviate knee osteoarthritis via multi-target modulation of PI3K-Akt, MAPK and HIF-1α signaling: an integrative UPLC-Q-TOF-MS/MS, network pharmacology and molecular dynamics study

in Network Bioinformatics

Wenqiang Qian
jiangyi zeng

Frontiers in Bioinformatics

Original Research

Accepted on 13 Apr 2026

Comparative Transcriptomics and Computational Drug Discovery Identify ASPM as a Key Oncogenic Driver and Therapeutic Target in Hepatocellular Carcinoma

in Integrative Bioinformatics

Pan Li
Aiye Guo
MingJing Zhao
GuangHui Chen

Frontiers in Bioinformatics

Review

Published on 13 Apr 2026

AI-driven discovery in protein science for immunology and infectious disease research

in Protein Bioinformatics

Mohamed Helmy
Fatma Shafei
Diogo Pellegrina
Lingling Jin
Amr Alhossary
Heather L. Wilson
Tamer Mansour
Kumar Selvarajoo

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1760257

242 views

Correction

Published on 13 Apr 2026

Correction: Human-associated NDM-5-producing multidrug-resistant Escherichia coli detected in retail beef and pork in Hungary, 2021

in Integrative Bioinformatics

Frontiers Production Office

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1842628

Original Research

Accepted on 10 Apr 2026

HVIface: Sequence-Based Deep Learning for Decoding Human-Virus Protein-Protein Interfaces

in Protein Bioinformatics

Krishna Kant Gupta
Monty Vijayvargiya
Geetha Paul
Ninan Sajeeth Philip
Radha Chauhan

Frontiers in Bioinformatics

Original Research

Accepted on 10 Apr 2026

N2SIMBA: from Network topology to SIMulation of interactions and BActerial abundance, using microbial consumer resource model

in Integrative Bioinformatics

Matteo Baldan
Giacomo Baruzzo
Piero Mariotto
Ada Rossato
Marco Cappellato
Barbara Di Camillo

Frontiers in Bioinformatics

Original Research

Published on 10 Apr 2026

Elucidating binding hot spots and structural stability in sirtuin family proteins for selective inhibitors: a computational approach

in Protein Bioinformatics

Deepak Sharma
Rajiniraja Muniyan

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1786061

125 views

Original Research

Published on 10 Apr 2026

Bulk RNA-seq datasets analysis integration identifies robust drought-responsive genes and functional networks in Eucalyptus grandis

in Genomic Analysis

João Vítor Aires-Teixeira
Nivea Maria Pereira Lima
Renato Almeida Sarmento
Gabriel Quintanilha-Peixoto
Kellen Kauanne Pimenta de Oliveira

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1743474

133 views

Original Research

Published on 10 Apr 2026

Integrated molecular dynamics elucidation of TP53 H179 zinc-binding variants: genomic and structural characterization across NSCLC subtypes

in Genomic Analysis

Ankur Datta
C. George Priya Doss

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1736501

130 views

Original Research

Published on 10 Apr 2026

Ergosterol as a natural modulator of intestinal cholesterol absorption via NPC1L1: an in silico insight into hypercholesterolemia

in Drug Discovery in Bioinformatics

Aparna G. Shenoy
Amrithesh Sureshkumar
Vishal Ravi
Rajesh Raju
Niyas Rehman

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1734995

202 views

Original Research

Published on 09 Apr 2026

Characterizing miRNA editing patterns in 5 types of cells using single-cell small RNA sequencing data

in RNA Bioinformatics

Chunyi Mao
Hao Guo
Wenping Xie
Yue Xu
Hongjia Zhang
Kang Luo
Jun Yang
Yun Zheng

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1719535

131 views

Original Research

Accepted on 08 Apr 2026

Discovering TEAD4 Modulators for Hepatocellular Carcinoma: A GAN-Enabled Generative Modelling Framework

in Drug Discovery in Bioinformatics

Varshni Premnath
Ramanathan Karuppasamy
Jayakumar Kaliappan
Shanthi Veerappapillai

Frontiers in Bioinformatics

Review

Accepted on 08 Apr 2026

Temporal Network Analysis in Systems Biology: Concepts, Inference, and Validation

in Network Bioinformatics

Abir Khazaal
Fatemeh Vafaee

Frontiers in Bioinformatics

Original Research

Published on 08 Apr 2026

Bioinformatics strategies and biomarker refinement using high-throughput transcriptome data in transplantation

in Genomic Analysis

Oliver P. Günther
Karen R. Sherwood
Franz Fenninger
Robert F. Balshaw
Andreas Scherer
Zsuzsanna Hollander
Raymond Ng
Janet Wilson-McManus
W. Robert McMaster
Bruce M. McManus

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1677453

292 views

Original Research

Published on 08 Apr 2026

Transcriptomics-driven identification of CDK1 as a central oncogenic driver in TNBC: an in silico structural modeling and MD simulation approach

in Drug Discovery in Bioinformatics

Uma Chaudhary
Sidharth Kumar Nanda Kumar
Magesh Ramaswamy
Mythili Asaithambi

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1766384

200 views

Original Research

Accepted on 07 Apr 2026

Integrative Multi-Cohort Analysis of DNA Methylation Profiles for Pancreatic Ductal Adenocarcinoma Biomarker Discovery and Prognosis

in Integrative Bioinformatics

Humera Inayat
Mohammad Aazam

Frontiers in Bioinformatics

Review

Published on 07 Apr 2026

Artificial intelligence in drug discovery from advanced molecular representation to pipeline applications

in Network Bioinformatics

Xiaoyu Zhou
Weijing Tao

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1755843

369 views

Systematic Review

Published on 07 Apr 2026

Unveiling the thioredoxin fold: a systematic review and bioinformatic analysis of protein disulfide isomerase and Dsb family proteins

in Protein Bioinformatics

Daniel Cuevas Ortiz
Karen Werner
Maria Fernanda Frias Mayo
Pablo A. Cárdenas Arredondo
Gabriela F. García Manzano
Cristina Revilla-Monsalve
Héctor Retana
Nelly F. Altamirano-Bustamante
Myriam M. Altamirano-Bustamante

Frontiers in Bioinformatics

doi 10.3389/fbinf.2026.1776111

155 views

673 articles

articles

Self-organizing maps for allele specific expression data reconstruction and identification of anomalous genomic regions

Resolving heterogeneity in Lymph Node Stromal Cells using high-dimensional analysis of non-optimized flow cytometry data

Transcriptomics-Guided Discovery of Interleukin-6 Modulators from Bacillus subtilis Metabolites in Type 2 Diabetes Mellitus

Predicting Anthropometric Body Composition Variables Using 3D Optical Imaging and Machine Learning

BlinkFusion: Modular platform quantifying labeling efficiency and photophysics in regular and super-resolution fluorescence microscopy

Corrigendum: An integrated automated deep learning framework for annotating tumor-infiltrating lymphocytes in lung adenocarcinoma pathology

Licorice-derived prenylated chalcones alleviate knee osteoarthritis via multi-target modulation of PI3K-Akt, MAPK and HIF-1α signaling: an integrative UPLC-Q-TOF-MS/MS, network pharmacology and molecular dynamics study

Comparative Transcriptomics and Computational Drug Discovery Identify ASPM as a Key Oncogenic Driver and Therapeutic Target in Hepatocellular Carcinoma

AI-driven discovery in protein science for immunology and infectious disease research

Correction: Human-associated NDM-5-producing multidrug-resistant Escherichia coli detected in retail beef and pork in Hungary, 2021

HVIface: Sequence-Based Deep Learning for Decoding Human-Virus Protein-Protein Interfaces

N2SIMBA: from Network topology to SIMulation of interactions and BActerial abundance, using microbial consumer resource model

Elucidating binding hot spots and structural stability in sirtuin family proteins for selective inhibitors: a computational approach

Bulk RNA-seq datasets analysis integration identifies robust drought-responsive genes and functional networks in Eucalyptus grandis

Integrated molecular dynamics elucidation of TP53 H179 zinc-binding variants: genomic and structural characterization across NSCLC subtypes

Ergosterol as a natural modulator of intestinal cholesterol absorption via NPC1L1: an in silico insight into hypercholesterolemia

Characterizing miRNA editing patterns in 5 types of cells using single-cell small RNA sequencing data

Discovering TEAD4 Modulators for Hepatocellular Carcinoma: A GAN-Enabled Generative Modelling Framework

Temporal Network Analysis in Systems Biology: Concepts, Inference, and Validation

Bioinformatics strategies and biomarker refinement using high-throughput transcriptome data in transplantation

Transcriptomics-driven identification of CDK1 as a central oncogenic driver in TNBC: an in silico structural modeling and MD simulation approach

Integrative Multi-Cohort Analysis of DNA Methylation Profiles for Pancreatic Ductal Adenocarcinoma Biomarker Discovery and Prognosis

Artificial intelligence in drug discovery from advanced molecular representation to pipeline applications

Unveiling the thioredoxin fold: a systematic review and bioinformatic analysis of protein disulfide isomerase and Dsb family proteins