PERSPECTIVE article
Front. Catal.
Sec. Homogeneous Catalysis
Volume 5 - 2025 | doi: 10.3389/fctls.2025.1635370
This article is part of the Research TopicRedefining Industrial Catalysis: Metrics and Methods for a Greener FutureView all articles
How to develop a sustainable palladium-catalyzed cross-coupling reactions for active ingredient manufacture
Provisionally accepted
- Euroapi, Haverhill, United Kingdom
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This Perspective reflects on practices that lead to the development of high turnover crosscoupling catalytic cycles involving palladium. These processes are attractive for the manufacture of agrochemical, human or veterinary active ingredients, and in some respects are more sustainable than alternatives that use base metals at much higher loadings. The practices are structured in terms of important elements of the workflow for developing a cross-coupling for commercialization, and are discussed using the key metrics that drive catalytic efficiency and sustainability. Realistic opportunities and challenges for metal recovery and reuse are also among the messages discussed.
Keywords: Palladium, Cross-coupling, turnover, Catalysis, metrics, workflow
Received: 26 May 2025; Accepted: 19 Sep 2025.
Copyright: © 2025 Steven. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Alan Steven, kjwx109@gmail.com
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