In the original article, we made the incorrect statement that non-viral vectors do not work in vivo, as below:
“Although the use of non-viral vectors could be attractive as they are generally safe, cheap and relative easy to produce, these approaches do not work in vivo”
This mistake was due to the fact that we meant to refer to epilepsy. Non-viral vectors have provided promising results for other applications, even if less for central nervous system disorders and in no case for epilepsy.
A correction has been made to section “Gene Therapy Approaches”, Paragraph 3:
In the past few years, the use of non-viral vectors has made a big step up for both in vitro and in vivo applications (Hardee et al., ). If compared to their viral counterpart, these tools are deemed to be generally safer, cheaper and relatively easier to produce. However, their employment for in vivo CNS targeting is still hindered by inadequate efficiency of transduction and transient expression of the transgene. At least so far, there is no evidence of efficacy for epilepsy treatment in preclinical or clinical studies by delivery of nucleic acids through non-viral systems.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way.
The original article has been updated.
Statements
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References
1
HardeeC. L.Arévalo-SolizL. M.HornsteinB. D.ZechiedrichL. (2017). Advances in non-viral DNA vectors for gene therapy. Genes8:65. 10.3390/genes8020065
Summary
Keywords
epilepsy, cell therapy, delivery devices, gene therapy, herpes-based vector
Citation
Falcicchia C, Simonato M and Verlengia G (2018) Corrigendum: New Tools for Epilepsy Therapy. Front. Cell. Neurosci. 12:212. doi: 10.3389/fncel.2018.00212
Received
26 June 2018
Accepted
27 June 2018
Published
11 July 2018
Approved by
Frontiers In Cellular Neuroscience Editorial Office, Frontiers Media SA, Switzerland
Volume
12 - 2018
Updates
Copyright
© 2018 Falcicchia, Simonato and Verlengia.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Gianluca Verlengia verlengia.gianluca@hsr.it
Disclaimer
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