MINI REVIEW article
Front. Cell. Neurosci.
Sec. Cellular Neuropathology
This article is part of the Research TopicExpanding the Glial Frontiers: Development, Function and PathophysiologyView all 6 articles
Radial Glia at the Neurovascular Interface During Cortical Development
Provisionally accepted
- 1Weill Cornell Medicine, New York, United States
- 2Weill Cornell Medicine, Cornell University, New York, United States
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Radial glia are a specialized population of neural progenitor cells that persist throughout embryogenesis and into adulthood. Throughout this period, radial glia reside in a highly dynamic microenvironment that influences various biological decisions that govern typical cortical development. Subsequently, radial glia must fine-tune their responses to numerous environmental cues throughout development. The establishment of the cortical vasculature coincides with neurogenesis and dramatically alters the radial glia microenvironment by increasing oxygen and metabolite delivery. In addition, a synergistic spatial relationship between radial glia and endothelial cells regulates multiple aspects of radial glial biology. Here, we discuss crosstalk between radial glia and the cortical vasculature/endothelial cells throughout development, including the influence of extrinsic angiogenic processes and our growing understanding of the intricate spatial relationships between radial glia and endothelial cells.
Keywords: Angiogenesis, cortex development, Endothelial cell (EC), Neural Stem / Progenitor Cells, Neurogenesis
Received: 14 Jan 2026; Accepted: 31 Jan 2026.
Copyright: © 2026 Al Naama and Pearson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Caroline Alayne Pearson
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