ORIGINAL RESEARCH article
Front. Chem. Biol.
Sec. Bioinorganic Chemistry
Volume 4 - 2025 | doi: 10.3389/fchbi.2025.1639096
This article is part of the Research TopicChemical Biology and Coordination ChemistryView all 3 articles
Article type: Research Paper Carboxymethyl Cellulose Hydrogel Doped with Zinc-Aspirinate as a Multifunctional Material: Photoprotection, Epithelial Regeneration, and Biocompatibility
Provisionally accepted
- 1Biological Inorganic Chemistry laboratory, Department of Chemistry, University of Ioannina, Ioannina, Greece
- 2Aristoteleio Panepistemio Thessalonikes, Thessaloniki, Greece
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The synthesis of a new Carboxymethyl Cellulose Hydrogel (CMC) doped with Zinc-Aspirinate (ZnAsp= [Zn(Asp)2(H2O)2]) of formula CMC@ZnAsp is reported. The hydrogel CMC@ZnAsp and its ingredient ZnAsp were characterized by melting point (m.p.) and X-Ray Fluorescence (XRF), Attenuated Total Reflection Fourier-Transform Infrared (ATR-FTIR) and Nuclear Magnetic Resonance (¹H-NMR) spectroscopies. The photo-reactivity of CMC@ZnAsp and its constituent ZnAsp under UVB radiation (λmax= 280 nm) was monitoring using 1 H-NMR spectroscopy. The in vitro cytotoxicity of both CMC@ZnAsp and ZnAsp was assessed against immortalized human keratinocyte (HaCaT) cells. Their potential role in promoting wound healingspecifically, the growth and migration of new epithelial cells to restore the integrity of the skin -was investigated using a scratch assay on HaCaT cells. Furthermore, the in vitro anti-inflammatory activity of CMC@ZnAsp and ZnAsp was also examined. Their in vivo toxicity was evaluated by Artemia salina assay.
Keywords: Biological inorganic chemistry, Zinc, Hydrogel, Epithelial regeneration, Toxicity
Received: 01 Jun 2025; Accepted: 15 Jul 2025.
Copyright: © 2025 Banti, Lezos, Hatzidimitriou and Hadjikakou. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Sotiris K Hadjikakou, Biological Inorganic Chemistry laboratory, Department of Chemistry, University of Ioannina, Ioannina, Greece
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