Frontiers in Drug Delivery | Technological and Methodological Advances in Drug Delivery

Original Research

Accepted on 15 Dec 2025

Targeting F2R/PAR1 with ligand decorated lipid nanocarriers for enhanced drug delivery into ovarian cancer cells

in Technological and Methodological Advances in Drug Delivery

Riya Khetan
Weranga Rajapaksha
Bukuru D Nturubika
Todd A Gillam
Douglas Alexander Brooks
Sanjay Garg
Anton Blencowe
Hugo Albrecht
Preethi Eldi

Frontiers in Drug Delivery

114 views

Original Research

Published on 12 Dec 2025

Mechanics-guided parametric modeling of intranasal spray devices and formulations for targeted drug delivery to the nasopharynx

in Technological and Methodological Advances in Drug Delivery

Md Tariqul Hossain
Abir Malakar
Mohammad Yeasin
William O’Connell
Mohammad Mehedi Hasan Akash
Azadeh A. T. Borojeni
Devranjan Samanta
Gerallt Williams
Joshua Reineke
Gonçalo Farias

Frontiers in Drug Delivery

doi 10.3389/fddev.2025.1721960

557 views

Mini Review

Published on 08 Dec 2025

Use of encapsulated dexamethasone sodium phosphate (eDSP) in chronic obstructive pulmonary disease, cystic fibrosis, and inflammatory bowel disorders

in Technological and Methodological Advances in Drug Delivery

Biljana Horn
Giovanni Mambrini
Maureen Roden
Caralee Schaefer
Dirk Thye
Mauro Magnani

Frontiers in Drug Delivery

doi 10.3389/fddev.2025.1730142

427 views

Editorial

Published on 10 Sep 2025

Editorial: Recent advancements and developments in targeted drug delivery systems for cancer diagnosis and therapy

in Technological and Methodological Advances in Drug Delivery

Abhishesh Kumar Mehata
Bipin Chaurasia
Ana Isabel Fraguas-Sánchez

Frontiers in Drug Delivery

doi 10.3389/fddev.2025.1654788

1,078 views

Review

Published on 26 Aug 2025

Strategies for delivering drugs across the blood-brain barrier for the treatment of neurodegenerative diseases

in Technological and Methodological Advances in Drug Delivery

Xiaopei Zhang
Manfei Fu
Yuanfei Wang
Tong Wu

Frontiers in Drug Delivery

doi 10.3389/fddev.2025.1644633

5,530 views
1 citation

Review

Published on 30 Jul 2025

Nickel nanoparticles: a novel platform for cancer-targeted delivery and multimodal therapy

in Technological and Methodological Advances in Drug Delivery

Fengyu Wang
Sen Tong
Xuan Ma
Huan Yang
Tianbao Zhang
Kunrong Wu
Junzi Wu

Frontiers in Drug Delivery

doi 10.3389/fddev.2025.1627556

2,163 views
1 citation

Review

Published on 27 Jun 2025

Advanced drug delivery systems for oral squamous cell carcinoma: a comprehensive review of nanotechnology-based and other innovative approaches

in Technological and Methodological Advances in Drug Delivery

Alain Herrada Céspedes
Montserrat Reyes
Javier O. Morales

Frontiers in Drug Delivery

doi 10.3389/fddev.2025.1596964

3,952 views
7 citations

Review

Published on 30 May 2025

Revolutionizing healthcare: the transformative potential of nanotechnology in medicine

in Technological and Methodological Advances in Drug Delivery

Lavan K. Durgam
Terry L. Oroszi

Frontiers in Drug Delivery

doi 10.3389/fddev.2025.1556426

15,901 views
4 citations

Editorial

Published on 26 Nov 2024

Editorial: 3D printing in pharmaceuticals and medical applications

in Technological and Methodological Advances in Drug Delivery

Italo Rodrigo Calori
Dimitrios A. Lamprou

Frontiers in Drug Delivery

doi 10.3389/fddev.2024.1527225

1,917 views

Review

Published on 08 Aug 2024

Strategies and delivery systems for cell-based therapy in autoimmunity

in Technological and Methodological Advances in Drug Delivery

Matteo Puccetti
Claudio Costantini
Aurélie Schoubben
Stefano Giovagnoli
Maurizio Ricci

Frontiers in Drug Delivery

doi 10.3389/fddev.2024.1436842

4,664 views
4 citations

Correction

Published on 18 Jul 2024

Corrigendum: Core-shell 3D printed biodegradable calcium phosphate cement – Alginate scaffolds for possible bone regeneration applications

in Technological and Methodological Advances in Drug Delivery

Clara Schweiker
Sergej Zankovic
Anna Baghnavi
Dirk Velten
Hagen Schmal
Ralf Thomann
Michael Seidenstuecker

Frontiers in Drug Delivery

doi 10.3389/fddev.2024.1452132

1,466 views

Original Research

Published on 05 Jun 2024

SpheroMold: modernizing the hanging drop method for spheroid culture

in Technological and Methodological Advances in Drug Delivery

Ana Paula Pereira Guimaraes
Italo Rodrigo Calori
Hong Bi
Antonio Claudio Tedesco

Frontiers in Drug Delivery

doi 10.3389/fddev.2024.1397153

7,064 views
3 citations

Original Research

Published on 22 May 2024

3D-printed weight holders design and testing in mouse models of spinal cord injury

in Technological and Methodological Advances in Drug Delivery

Sara De Vincentiis
Francesca Merighi
Peter Blümler
Jose Gustavo De La Ossa Guerra
Mariachiara Di Caprio
Marco Onorati
Marco Mainardi
Vittoria Raffa
Marina Carbone

Frontiers in Drug Delivery

doi 10.3389/fddev.2024.1397056

4,591 views
1 citation

Original Research

Published on 17 May 2024

Core-shell 3D printed biodegradable calcium phosphate cement—Alginate scaffolds for possible bone regeneration applications

in Technological and Methodological Advances in Drug Delivery

Clara Schweiker
Sergej Zankovic
Anna Baghnavi
Dirk Velten
Hagen Schmal
Ralf Thomann
Michael Seidenstuecker

Frontiers in Drug Delivery

doi 10.3389/fddev.2024.1407304

2,309 views
1 citation

Original Research

Published on 06 Mar 2024

Geometry impact on fundamental properties of theophylline-containing SLS printed pharmaceutical tablets

in Technological and Methodological Advances in Drug Delivery

Valerie R. Levine
Christos S. Katsiotis
Maria Strømme
Julian Quodbach
Jonas Lindh

Frontiers in Drug Delivery

doi 10.3389/fddev.2024.1358336

2,376 views
5 citations

Original Research

Published on 05 Mar 2024

Single cell phototransfection of mRNAs encoding SARS-CoV2 spike and nucleocapsid into human astrocytes results in RNA dependent translation interference

in Technological and Methodological Advances in Drug Delivery

Hyun-Bum Kim
Quentin Brosseau
Julia Radzio
Jinhui Wang
Hiromi Muramatsu
Da Kuang
M. Sean Grady
H. Isaac Chen
John A. Wolf
Alexandra V. Ulyanova

Frontiers in Drug Delivery

doi 10.3389/fddev.2024.1359700

2,335 views
1 citation

Review

Published on 01 Feb 2024

Future theranostic strategies: emerging ovarian cancer biomarkers to bridge the gap between diagnosis and treatment

in Technological and Methodological Advances in Drug Delivery

Weranga Rajapaksha
Riya Khetan
Ian R. D. Johnson
Anton Blencowe
Sanjay Garg
Hugo Albrecht
Todd A. Gillam

Frontiers in Drug Delivery

doi 10.3389/fddev.2024.1339936

8,068 views
13 citations

Original Research

Published on 31 Jan 2024

Release of delta-9-tetrahydrocannabinol from polyvinyl alcohol hydrogels and its safe interaction with human skin fibroblasts

in Technological and Methodological Advances in Drug Delivery

Shujun Cui
Ze Zhang
Denis Rodrigue
François Béland
Mahmoud Rouabhia

Frontiers in Drug Delivery

doi 10.3389/fddev.2024.1303812

2,865 views
2 citations

Original Research

Published on 24 Oct 2023

Mannose-functionalization of reconstituted high-density lipoprotein nanoparticles improves payload delivery and enhances M2-to-M1 phenotype reprogramming of RAW 264.7 macrophages polarized by B16-F10 melanoma cells

in Technological and Methodological Advances in Drug Delivery

Akpedje S. Dossou
Morgan E. Mantsch
Nirupama Sabnis
Rance E. Berg
Rafal Fudala
Andras G. Lacko

Frontiers in Drug Delivery

doi 10.3389/fddev.2023.1281066

4,259 views
2 citations

Original Research

Published on 24 Jul 2023

Impact of simulated brain interstitial fluid flow on the chemokine CXCL12 release from an alginate-based hydrogel in a new 3D in vitro model

in Technological and Methodological Advances in Drug Delivery

Wiam El Kheir
Anaïs Dumais
Maude Beaudoin
Bernard Marcos
Nick Virgilio
Benoit Paquette
Nathalie Faucheux
Marc-Antoine Lauzon

Frontiers in Drug Delivery

doi 10.3389/fddev.2023.1227776

2,902 views
8 citations

Original Research

Published on 20 Jul 2023

Polyethylene Glycol-grafted poly alpha-lipoic acid-dexamethasone nanoparticles for osteoarthritis

in Technological and Methodological Advances in Drug Delivery

Yuanqiang Cheng
Zheng Jing
Yan Xu
Lihui Sun
Dongbo Li
Jianguo Liu
Dongsong Li

Frontiers in Drug Delivery

doi 10.3389/fddev.2023.1168287

2,668 views

Methods

Published on 13 Jul 2023

Characterization of large volume subcutaneous injections using computed tomography imaging and simultaneous pressure measurements

in Technological and Methodological Advances in Drug Delivery

Mona Purcell
Sahab Babaee
Michael Galluppi
John Cline
Guangli Hu
Ioan Petrescu
Jennifer Hughes
Meredith Allen
Eric Messina
Steven Persak

Frontiers in Drug Delivery

doi 10.3389/fddev.2023.1223177

4,936 views
6 citations

Original Research

Published on 04 Apr 2023

Usefulness of direct intratumoral administration of doxorubicin hydrochloride with an electro-osmosis–assisted pump

in Technological and Methodological Advances in Drug Delivery

Ayu Ito
Shoko Itakura
Yuya Hasegawa
Miyu Hashimoto
Akie Okada
Mamoru Hirafuji
Hidenori Nakamura
Kenji Sugibayashi
Hiroaki Todo

Frontiers in Drug Delivery

doi 10.3389/fddev.2023.1150894

3,215 views
3 citations

Brief Research Report

Published on 23 Aug 2022

Comparison of three methods for assessment of drug elution: In vitro elution of gentamicin from a collagen-based scaffold

in Technological and Methodological Advances in Drug Delivery

Caroline Billings
David E. Anderson

Frontiers in Drug Delivery

doi 10.3389/fddev.2022.958731

2,797 views
2 citations