Relationship between Triglyceride-Glucose Index and mortality in ICU in acute pancreatitis patients: a retrospective cohort study using the MIMIC database

Qianhui Wang¹haibo Cong^2*

• ¹Shandong University of Traditional Chinese Medicine, Jinan, China
• ²Limin Hospital of Weihai Gao District, weihai, China

Background: Triglyceride glucose index (TyG) is associated with poor prognosis in patients with acute pancreatitis (AP). However, the clinical relationship between the triglyceride-glucose index and mortality in hospitalized patients with acute pancreatitis in the intensive care unit (ICU) is not yet clear. Methods: In this retrospective cohort study, the clinical data of patients with acute pancreatitis were collected from the Intensive Care Medical Information Market IV (MIMIC-IV) database, with mortality as an outcome variable. The formula for calculating the triglyceride glucose index (TyG) was as follows: ln [fasting triglyceride (mg/dL) × fasting blood glucose (mg/dL)/2]. Multivariate Cox regression analysis was used to calculate the adjusted risk ratio (HR) and the corresponding 95% confidence interval (CI).Results: This study included 318 patients with acute pancreatitis, with an average age of 56.8 ± 16.3 years, of which 62.3% were male. The mortality rate was 9.43% (30/318). After adjusting for potential confounding factors, we found that the triglyceride glucose index as a continuous variable was not statistically significant; When the triglyceride glucose index triad was used as the categorical variable, the low-value group was used as the baseline reference, and the high value group had a triglyceride glucose index (10.224-13.873 mg/dL category compared to 9.261-9.576 mg/dL category) that was associated with a lower risk of in-hospital mortality (HR: 0.27; 95% CI 0.09-0.79; P<0.05).Conclusions: There is a non-linear relationship between the triglyceride glucose index and mortality in patients with acute pancreatitis in the intensive care unit, which warrants further research.