REVIEW article
Front. Gastroenterol.
Sec. Gastroenterology and Cancer
Volume 4 - 2025 | doi: 10.3389/fgstr.2025.1607612
Meta-analysis of ultrasound dual contrast for T-staging of gastric cancer
Provisionally accepted
- First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, China
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Purpose: To systematically evaluate the diagnostic value of doublecontrast ultrasound in T-staging of gastric cancer. Methods: Relevant studies were identified through systematic searches in PubMed, CNKI, and Wanfang databases using keywords "contrast-enhanced ultrasound," "gastric cancer," and "T staging." Eligible studies evaluating double-contrast ultrasound for T-staging of gastric cancer were included. RevMan 5.3 software was employed to generate summary receiver operating characteristic (SROC) curves and calculate pooled sensitivity, specificity, and area under the curve (AUC). Results: Nine studies involving 977 patients were analyzed. For T1-stage diagnosis, pooled sensitivity, specificity, and AUC were 0.85 (95% CI 0.76-0.92), 0.97 (0.96-0.98), and 0.9908, respectively. T2-stage analysis yielded values of 0.71 (0.64-0.77), 0.93 (0.91-0.94), and 0.7689. T3-stage results showed 0.79 (0.75-0.83), 0.85 (0.82-0.88), and 0.8770, while T4-stage parameters were 0.77 (0.72-0.82), 0.93 (0.91-0.95), and 0.9264. Conclusion: Double-contrast ultrasound demonstrates robust diagnostic performance for T-staging of gastric cancer, with high specificity across all stages and superior accuracy for early-stage detection (T1). These findings support its clinical utility as a non-invasive imaging tool for preoperative assessment of gastric cancer progression.
Keywords: gastric cancer, ultrasound, Gastric tumor, Tumor staging, Meta - analysis
Received: 07 Apr 2025; Accepted: 29 Apr 2025.
Copyright: © 2025 于, liu, Li, Ma, liu and zheng. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence:
洋 于, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, China
wen liu, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, China
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