REVIEW article
Front. Gastroenterol.
Sec. Therapy in Gastroenterology
Volume 4 - 2025 | doi: 10.3389/fgstr.2025.1626610
This article is part of the Research TopicAdvances in Inflammatory Bowel Disease: Treatment, Targets and TherapyView all 4 articles
Gastrointestinal Endoscopy for Intestinal Dysplasia and Neoplasia Detection and Management in Crohn's Disease: When and How?
Provisionally accepted
Tommaso Pessarelli1
Gian Eugenio Tontini2,3*Alessandra Piagnani1Irene Maria Bambina Bergna1Arnaldo Amato1- 1Dipartimento di Endoscopia Digestiva e Gastroenterologia, ASST Lecco, Lecco, Italy
- 2Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
- 3Gastroenterology and Endoscopy Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy
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Patients with long-standing inflammatory bowel disease (IBD) involving the colon have an approximately 2-3-fold risk of colorectal cancer (CRC), which remains a leading cause of mortality in this population. However, data specifically assessing CRC incidence in Crohn's disease (CD) are limited, and these patients also face an increased risk of small bowel cancer (SBC). Endoscopy plays a central role in CRC prevention, as well as in the detection and management of dysplasia and early CRC in CD. This review summarizes current evidence on the role of lower gastrointestinal endoscopy, as well as small bowel capsule endoscopy and device assisted enteroscopy, in this context. It provides practical guidance on the optimal use of these endoscopic techniques, considering patient-and disease-specific factors. Additionally, it highlights emerging endoscopic technologies and future perspectives in the field.
Keywords: Endoscopy and Crohn's disease, colorectal neoplasia and Crohn's disease, small bowel neoplasia and Crohn's disease, cancer and Crohn's disease, dysplasia and Crohn's disease
Received: 11 May 2025; Accepted: 16 Jun 2025.
Copyright: © 2025 Pessarelli, Tontini, Piagnani, Bergna and Amato. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Gian Eugenio Tontini, Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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