CASE REPORT article
Front. Gastroenterol.
Sec. Gastroenterology and Cancer
Endoscopic Submucosal Dissection for a Large (Exceeding3 cm) 1 Exophytic Gastric Schwannoma with 24-Hour Intragastric Retention: 2 A Case Report and Brief Literature Review 3
Rong Xie
Weiwei Zhang
YanningI Mao
Yi Qin
Jiaxu Wang
Qi Luo
Linhua Teng
Jiawen Liu
The Fifth People's Hospital of Nanning, Nanning, China
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Abstract
Background: The clinical role of endoscopic resection in the treatment 14 of exophytic gastric schwannomas measuring ≥3 cm remains 15 controversial owing to technical difficulties and a paucity of evidence. 16 Case presentation: A 58-year-old female patient was admitted for 17 treatment after a gastric mass was discovered during routine physical 18 examination. Endoscopic ultrasonography (EUS) revealed a 19 well-demarcated, hypoechoic submucosal tumor measuring 40.9×32.3 20 mm. The patient subsequently underwent endoscopic submucosal 21 dissection (ESD) under general anesthesia . Histopathological analysis 22 confirmed the diagnosis of gastric schwannoma, with 23 immunohistochemical staining showing strong S-100 protein positivity . 24 The patient had an uneventful recovery with no procedure-related 25 complications, and there has been no evidence of recurrence to date. 26 Conclusion: While this single-case experience indicates the technical 27 feasibility of ESD for gastric schwannomas >3 cm, larger-scale 28 prospective studies are required to establish its role in clinical practice. 29 Trial registration: Not applicable.
Summary
Keywords
Endoscopic Submucosal Dissection, Gastric schwannoma, Exceeding3 cm, Exophytic, S100
Received
11 September 2025
Accepted
04 November 2025
Copyright
© 2025 Xie, Zhang, Mao, Qin, Wang, Luo, Teng and Liu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Rong Xie
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