In the original article, we included a supplementary material “Presentation 1.PDF.” The original purpose of this supplementary material is to provide readers with more explanation of the marginal structural model (MSM) we used for mediation analysis. However, we made some mistakes in the mathematical expression in the supplementary material which can be misleading. For more details about the model, it would be better for readers to directly refer to the three cited articles in which the model is proposed. Thus, we think that this supplementary material is inaccurate and redundant, and should be removed. Note that this supplementary material was only for illustrative purpose and does not affect any results in the article. So removing it will not change anything else in the article. In addition, we should have added in the subsection “Pleiotropic Meta-Analysis” the following statement “We checked the multivariate normality assumption for these summary statistics under the null hypothesis using the Henze-Zirkler test (Henze and Zirkler, 1990), and found no evidence of violation of the assumption.” This statement ensures the validity of the omnibus test for our analyses.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way.
The original article has been updated.
Statements
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References
1
HenzeN.ZirklerB. (1990). A class of invariant consistent tests for multivariate normality. Comm. Statist. Theory Methods19, 3595–3617. 10.1080/03610929008830400
Summary
Keywords
pleiotropic analysis, age-related traits, CVDs, genetic association study, mediation analysis, age-dependent effects
Citation
He L, Kernogitski Y, Kulminskaya I, Loika Y, Arbeev KG, Loiko E, Bagley O, Duan M, Yashkin A, Ukraintseva SV, Kovtun M, Yashin AI and Kulminski AM (2018) Corrigendum: Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases. Front. Genet. 8:226. doi: 10.3389/fgene.2017.00226
Received
29 October 2017
Accepted
15 December 2017
Published
12 January 2018
Volume
8 - 2017
Edited and reviewed by
Frontiers in Genetics, Frontiers Media SA, Switzerland
Updates
Copyright
© 2018 He, Kernogitski, Kulminskaya, Loika, Arbeev, Loiko, Bagley, Duan, Yashkin, Ukraintseva, Kovtun, Yashin and Kulminski.
This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Liang He lianghe@mit.edu
This article was submitted to Genetics of Aging, a section of the journal Frontiers in Genetics
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