ORIGINAL RESEARCH article
Front. Genet.
Sec. Cancer Genetics and Oncogenomics
This article is part of the Research TopicComparative Genomics and Functional Genomics Analyses in CancerView all 13 articles
CDKN2AIPNL: a potential pan-cancer biomarker
Provisionally accepted
- Department of Gastrocolorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, China
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Cancer progression involves dynamic crosstalk between tumor-intrinsic pathways and microenvironmental remodeling. This study is the first systematic pan-cancer analysis to reveal the dual role of CDKN2AIPNL in tumorigenesis and its association with tumor microenvironment remodeling. Utilizing TCGA datasets, we demonstrated that CDKN2AIPNL expression is significantly upregulated in LIHC (HR=1.7, p=0.0026), UVM (HR=26, p=2.2e-6), BRCA (HR=26, p=2.2e-6), THYM (HR=3, p=0.023), LUAD (HR=1.36, p=0.049), PCPG (HR=1.71, p=0.0012), and TGCT (HR=0.37, p=0.023), correlating with worse overall survival (OS), disease-free survival (DFS), and progression-free survival (PFS). Genomic analyses reveal frequent amplifications and mutations, particularly in prostate and renal cancers, linked to poor overall survival (p <0.001). Gene expression associates with cancer-associated fibroblast infiltration, suggesting a role in shaping the tumor microenvironment. Protein interaction and enrichment analyses highlight its involvement in DNA repair, cell cycle regulation, and energy metabolism through interactions with regulators like MYC and XRN2. Our findings propose CDKN2AIPNL as a candidate pan-cancer biomarker linked to metabolic reprogramming and immune evasion, with potential implications for precision oncology.
Keywords: CDKN2AIPNL, metabolic reprogramming, Pan-cancer, prognostic biomarker, Tumor Microenvironment
Received: 05 Mar 2025; Accepted: 12 Dec 2025.
Copyright: © 2025 Zhang, Liu, Sun, Gong and Wang. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Quan Wang
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