SYSTEMATIC REVIEW article
Front. Genet.
Sec. Cancer Genetics and Oncogenomics
Volume 16 - 2025 | doi: 10.3389/fgene.2025.1618597
This article is part of the Research TopicUnraveling Germline Mutations: Advances in Genetic Profiling for Cancer RiskView all articles
Association between the PSCA rs2976392 polymorphism and susceptibility to gastric cancer: a meta-analysis
Provisionally accepted
- Quzhou City People's Hospital, Quzhou, China
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Background: Genetic polymorphisms, such as PSCA rs2976392, have been implicated in gastric carcinogenesis, but it is unclear whether there is a direct association. Thus, we conducted a comprehensive meta-analysis to evaluate the association between the PSCA rs2976392 polymorphism and susceptibility to gastric cancer (GC).Methods: A systematic search of the PubMed, Web of Science, Embase, and Cochrane Library databases was performed up to March 13, 2025. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for five genetic models. Subgroup analyses were conducted according to ethnicity and Hardy-Weinberg equilibrium (HWE) status. Heterogeneity and publication bias were assessed, and sensitivity analyses were performed.Results: A total of 13 studies involving 9255 patients with gastric cancer and 8903 controls were included. Overall, a significant association between the PSCA rs2976392 polymorphism and increased GC risk was observed under the allele model (OR = 1.29, 95% CI: 1.19-1.40), dominant model (OR = 1.53, 95% CI: 1.3-1.77), homozygous model (OR = 1.52, 95% CI: 1.18-1.96), and heterozygous model (OR = 1.52, 95% CI: 1.33-1.73), but not under the recessive model. Subgroup analyses revealed a strong association in Asian populations with all genetic models, whereas Caucasians showed a significant association only with the homozygous model. No significant publication bias was detected, and sensitivity analyses confirmed the robustness of the results.This meta-analysis provides strong evidence that the PSCA rs2976392 AA genotype significantly increases susceptibility to gastric cancer, particularly among Asians.
Keywords: PSCA, Rs2976392, polymorphism, gastric cancer, Meta-analysis
Received: 26 Apr 2025; Accepted: 07 Jul 2025.
Copyright: © 2025 Lin, Chen, Li-Juan and Wan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
* Correspondence: Xiu-ping Wan, Quzhou City People's Hospital, Quzhou, China
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